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Table 3 Factors associated with sexual outcome trajectories assessed by the expanded prostate cancer index composite (EPIC)-50 among men in the prostatectomy, incontinence and erectile dysfunction (PIE) study

From: One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study

 

All participants n (%)

BPH-related factors

ED -elated factors

Prostate size

IPSS score

BPH medication use at baseline

BPH composite measure

ED medication use at baseline ED medication use at baseline

ED medication or device use at follow-up

 < 40 g

 ≥ 40 g

 < 8

 ≥ 8

No

Yes

No BPH

Any BPH

No

Yes

No

Yes

Sexual function 5 weeks post-surgery (n = 357)

Impaired

             

N

262 (79.0)

            

OR 95% CI

             

Maintained

             

N

69 (19.3)

            

OR 95% CI

             

Improved

             

N

6 (1.7)

            

OR 95% CI

             

Sexual function 12 months post-surgery (n = 332)

Impaired

             

N

229 (69.0)

76

96

73

73

205

24

91

138

217

12

70

154

OR 95% CI

 

Reference

Reference

Reference

Reference

Reference

Reference

Maintained

             

N

92 (27.7)

39

28

35

28

80

12

40

52

88

4

40

48

OR 95% CI

 

0.6 (0.3 to 1.0)

0.8 (0.4 to 1.4)

1.3 (0.6 to 2.7)

0.8 (0.5 to 1.4)

0.8 (0.3 to 2.6)

0.5 (0.3 to 0.9)

Improved

             

N

11 (3.3)

3

6

4

4

8

3

2

9

11

0

2

5

OR 95% CI

 

1.6 (0.4 to 6.5)

1.0 (0.2 to 4.2)

3.2 (0.8 to 13)

3.0 (0.6 to 14)

NE

1.1 (0.2 to 6.0)

Sexual bother 5 weeks post-surgery (n = 354)

Impaired

             

N

259 (73.2)

94

96

86

77

232

27

110

149

243

16

117

131

OR 95% CI

 

Reference

Reference

Reference

Reference

Reference

Reference

Maintained

             

N

69 (19.5)

27

27

27

22

61

8

30

39

69

0

36

24

OR 95% CI

 

1.0 (0.5 to 1.8)

0.9 (0.5 to 1.7)

1.1 (0.5 to 2.6)

1.0 (0.6 to 1.6)

NE

0.6 (0.3 to 1.1)

Improved

             

N

26 (7.3)

6

11

8

11

16

10

3

23

24

2

16

10

OR 95% CI

 

1.8 (0.6 to 5.1)

1.5 (0.6 to 4.0)

5.4 (2.2 to 13.0)

5.7 (1.7 to 19.3)

1.3 (0.3 to 5.8)

0.6 (0.2 to 1.3)

Sexual bother 12 months post-surgery (n = 329)

Impaired

             

N

229 (69.6)

78

89

81

67

206

23

98

131

216

13

68

157

OR 95% CI

 

Reference

Reference

Reference

Reference

Reference

Reference

Maintained

             

N

65 (19.8)

28

23

22

19

56

9

28

37

62

3

27

34

OR 95% CI

 

0.7 (0.4 to 1.4)

1.0 (0.5 to 2.1)

1.4 (0.6 to 3.3)

1.0 (0.6 to 1.7)

0.8 (0.2 to 2.9)

0.5 (0.3 to 1.0)

Improved

             

N

35 (10.6)

8

19

11

15

30

5

7

28

35

0

13

16

OR 95% CI

 

2.1 (0.9 to 5.0)

1.6 (0.7 to 3.8)

1.5 (0.5 to 4.2)

3.0 (1.2 to 7.1)

NE

0.5 (0.2 to 1.2)

  1. BPH benign prostatic hyperplasia, CI confidence interval, ED erectile dysfunction, IPSS International Prostate Symptom Score, OR odds ratio, NE not estimable
  2. EPIC-50 measured urinary and sexual outcome trajectories were defined as impaired (negative change greater than the upper bound of minimally important difference), maintained, and improved (positive change greater than the upper bound of minimally important difference). Sexual function, sexual bother: impaired (change < 12); maintained (-12 ≤ change ≤ 12); improved (change ≥ 12)
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BMC Urology

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