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Table 3 Factors associated with sexual outcome trajectories assessed by the expanded prostate cancer index composite (EPIC)-50 among men in the prostatectomy, incontinence and erectile dysfunction (PIE) study

From: One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study

  All participants n (%) BPH-related factors ED -elated factors
Prostate size IPSS score BPH medication use at baseline BPH composite measure ED medication use at baseline ED medication use at baseline ED medication or device use at follow-up
 < 40 g  ≥ 40 g  < 8  ≥ 8 No Yes No BPH Any BPH No Yes No Yes
Sexual function 5 weeks post-surgery (n = 357)
Impaired              
N 262 (79.0)             
OR 95% CI              
Maintained              
N 69 (19.3)             
OR 95% CI              
Improved              
N 6 (1.7)             
OR 95% CI              
Sexual function 12 months post-surgery (n = 332)
Impaired              
N 229 (69.0) 76 96 73 73 205 24 91 138 217 12 70 154
OR 95% CI   Reference Reference Reference Reference Reference Reference
Maintained              
N 92 (27.7) 39 28 35 28 80 12 40 52 88 4 40 48
OR 95% CI   0.6 (0.3 to 1.0) 0.8 (0.4 to 1.4) 1.3 (0.6 to 2.7) 0.8 (0.5 to 1.4) 0.8 (0.3 to 2.6) 0.5 (0.3 to 0.9)
Improved              
N 11 (3.3) 3 6 4 4 8 3 2 9 11 0 2 5
OR 95% CI   1.6 (0.4 to 6.5) 1.0 (0.2 to 4.2) 3.2 (0.8 to 13) 3.0 (0.6 to 14) NE 1.1 (0.2 to 6.0)
Sexual bother 5 weeks post-surgery (n = 354)
Impaired              
N 259 (73.2) 94 96 86 77 232 27 110 149 243 16 117 131
OR 95% CI   Reference Reference Reference Reference Reference Reference
Maintained              
N 69 (19.5) 27 27 27 22 61 8 30 39 69 0 36 24
OR 95% CI   1.0 (0.5 to 1.8) 0.9 (0.5 to 1.7) 1.1 (0.5 to 2.6) 1.0 (0.6 to 1.6) NE 0.6 (0.3 to 1.1)
Improved              
N 26 (7.3) 6 11 8 11 16 10 3 23 24 2 16 10
OR 95% CI   1.8 (0.6 to 5.1) 1.5 (0.6 to 4.0) 5.4 (2.2 to 13.0) 5.7 (1.7 to 19.3) 1.3 (0.3 to 5.8) 0.6 (0.2 to 1.3)
Sexual bother 12 months post-surgery (n = 329)
Impaired              
N 229 (69.6) 78 89 81 67 206 23 98 131 216 13 68 157
OR 95% CI   Reference Reference Reference Reference Reference Reference
Maintained              
N 65 (19.8) 28 23 22 19 56 9 28 37 62 3 27 34
OR 95% CI   0.7 (0.4 to 1.4) 1.0 (0.5 to 2.1) 1.4 (0.6 to 3.3) 1.0 (0.6 to 1.7) 0.8 (0.2 to 2.9) 0.5 (0.3 to 1.0)
Improved              
N 35 (10.6) 8 19 11 15 30 5 7 28 35 0 13 16
OR 95% CI   2.1 (0.9 to 5.0) 1.6 (0.7 to 3.8) 1.5 (0.5 to 4.2) 3.0 (1.2 to 7.1) NE 0.5 (0.2 to 1.2)
  1. BPH benign prostatic hyperplasia, CI confidence interval, ED erectile dysfunction, IPSS International Prostate Symptom Score, OR odds ratio, NE not estimable
  2. EPIC-50 measured urinary and sexual outcome trajectories were defined as impaired (negative change greater than the upper bound of minimally important difference), maintained, and improved (positive change greater than the upper bound of minimally important difference). Sexual function, sexual bother: impaired (change < 12); maintained (-12 ≤ change ≤ 12); improved (change ≥ 12)