Fig. 1

Prostate cancer hypoxia-associated genes interact at the protein level. The networks, generated using the STRING database, summarize predicted associations between proteins. The nodes represent proteins and only nodes with at least one connection are shown. The edges represent protein–protein interactions and the confidence of the interaction is indicated by the thickness of the edge. a Sixty-nine of the 103 hypoxia-associated genes identified in GSE21032 encoded proteins that interacted with at least one other protein in the network. On average each node had 3.6 connections and there are 185 edges representing protein–protein interactions. The observed number of edges in this network was more than expected at random with a protein–protein interaction enrichment value of p < 1 × 10^–16, indicating a highly interconnected network of proteins. b Fifty-five of the 66 hypoxia-associated genes from the TCGA interacted with at least one other protein in the network and had an average 8.2 connections. There are 271 edges representing protein–protein interactions and number is more than expected at random (p < 1 × 10^–16), indicating a highly interconnected network of proteins