Table 1 Top 10 FDA-approved drugs identified using connectivity mapping
From: Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer
Ranking | GSE21032 | TCGA | ||||
|---|---|---|---|---|---|---|
Drug | Cell line | Z-score¶ | Drug | Cell line | Z-score¶ | |
1 | MENADIONE | HEPG2 | – 15.8 | CLADRIBINE | A375 | – 17.5 |
2 | MENADIONE | A375 | – 14.0 | MENADIONE | A375 | – 15.6 |
3 | GEMCITABINE | A375 | – 13.1 | HOMOHARRINGTONINE | PC3 | – 15.0 |
4 | NICLOSAMIDE | HEPG2 | – 13.0 | MENADIONE | HEPG2 | – 14.6 |
5 | GEMCITABINE | HCC515 | – 12.1 | NICLOSAMIDE | HEPG2 | – 14.6 |
6 | CLADRIBINE | A375 | – 11.7 | DIGITOXIN | A549 | – 14.3 |
7 | DIGITOXIN | A549 | – 11.4 | AZACITIDINE | A375 | – 14.0 |
8 | DIGOXIN | PC3 | – 11.3 | CLOFARABINE | A375 | – 13.9 |
9 | PENTAMIDINE | HEPG2 | – 11.1 | GEMCITABINE | HCC515 | – 13.5 |
10 | TENIPOSIDE | A375 | – 11.1 | CLADRIBINE | PC3 | – 13.3 |