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Table 1 Top 10 FDA-approved drugs identified using connectivity mapping

From: Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

Ranking GSE21032 TCGA
Drug Cell line Z-score Drug Cell line Z-score
1 MENADIONE HEPG2 – 15.8 CLADRIBINE A375 – 17.5
2 MENADIONE A375 – 14.0 MENADIONE A375 – 15.6
3 GEMCITABINE A375 – 13.1 HOMOHARRINGTONINE PC3 – 15.0
4 NICLOSAMIDE HEPG2 – 13.0 MENADIONE HEPG2 – 14.6
5 GEMCITABINE HCC515 – 12.1 NICLOSAMIDE HEPG2 – 14.6
6 CLADRIBINE A375 – 11.7 DIGITOXIN A549 – 14.3
7 DIGITOXIN A549 – 11.4 AZACITIDINE A375 – 14.0
8 DIGOXIN PC3 – 11.3 CLOFARABINE A375 – 13.9
9 PENTAMIDINE HEPG2 – 11.1 GEMCITABINE HCC515 – 13.5
10 TENIPOSIDE A375 – 11.1 CLADRIBINE PC3 – 13.3
  1. p values < 0.001