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Table 2 Top 10 FDA-approved drugs identified using connectivity mapping in the prostate cancer cell lines

From: Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

Ranking GSE21032 TCGA
Drug Cell line Z-score Drug Cell line Z-score
1 DIGOXIN PC3 – 11.31 HOMOHARRINGTONINE PC3 – 14.98
2 OUABAIN PC3 – 10.48 CLADRIBINE PC3 – 13.29
3 DIGITOXIN PC3 – 9.83 DIGITOXIN PC3 – 13.15
4 BISACODYL PC3 – 9.56 MENADIONE VCAP – 12.56
5 CLOFARABINE PC3 – 9.42 DIGOXIN PC3 – 12.10
6 HOMOHARRINGTONINE PC3 – 8.86 OUABAIN PC3 – 11.59
7 ITRACONAZOLE PC3 – 8.84 GEMCITABINE PC3 – 11.56
8 MENADIONE VCAP – 8.69 AZACITIDINE PC3 – 10.16
9 GEMCITABINE PC3 – 8.36 BORTEZOMIB VCAP – 10.15
10 TENIPOSIDE PC3 – 8.35 CEFACLOR PC3 – 9.92