Table 2 Top 10 FDA-approved drugs identified using connectivity mapping in the prostate cancer cell lines
From: Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer
Ranking | GSE21032 | TCGA | ||||
|---|---|---|---|---|---|---|
Drug | Cell line | Z-score | Drug | Cell line | Z-score | |
1 | DIGOXIN | PC3 | – 11.31 | HOMOHARRINGTONINE | PC3 | – 14.98 |
2 | OUABAIN | PC3 | – 10.48 | CLADRIBINE | PC3 | – 13.29 |
3 | DIGITOXIN | PC3 | – 9.83 | DIGITOXIN | PC3 | – 13.15 |
4 | BISACODYL | PC3 | – 9.56 | MENADIONE | VCAP | – 12.56 |
5 | CLOFARABINE | PC3 | – 9.42 | DIGOXIN | PC3 | – 12.10 |
6 | HOMOHARRINGTONINE | PC3 | – 8.86 | OUABAIN | PC3 | – 11.59 |
7 | ITRACONAZOLE | PC3 | – 8.84 | GEMCITABINE | PC3 | – 11.56 |
8 | MENADIONE | VCAP | – 8.69 | AZACITIDINE | PC3 | – 10.16 |
9 | GEMCITABINE | PC3 | – 8.36 | BORTEZOMIB | VCAP | – 10.15 |
10 | TENIPOSIDE | PC3 | – 8.35 | CEFACLOR | PC3 | – 9.92 |