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Fig. 4 | BMC Urology

Fig. 4

From: Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma

Fig. 4

Knockdown of KDM2A suppresses the proliferation and invasion, and promotes the apoptosis of ccRCC cells. a qRT-PCR analysis and b western blot analysis showed that KDM2A mRNA and protein expression levels in 786-O cells transfection with si-KDM2A were notably downregulated than control and si-NC groups. c The proliferative ability of 786-O cells transfected with si-KDM2A was determined by CCK‑8 assay. d Representative image of transwell assay, quantitative measurement of the number of transmembrane cells indicates that knockdown of KDM2A reduces cellular invasion (Magnification, × 200). e The results of flow cytometry demonstrated that 786-O cells transfected with si-KDM2A had a higher apoptosis percentage (32.10 ± 2.60%) than control (5.66 ± 2.46%) and si-NC (6.83 ± 1.31%) group. *P < 0.05

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