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Table 2 Univariate and multivariate cox regression for prostate cancer incidence among overall patients

From: The effect of subsequent immunosuppressant use in organ-transplanted patients on prostate cancer incidence: a retrospective analysis using the Korean National Health Insurance Database

Characteristics N Event Duration IR (per 1000) Univariate Multivariate
HR p value HR p value
Age (years), 20 ≤ Age < 50 25,856 18 135,209.95 0.1331 0.098 (0.06,0.161) < .0001 0.113 (0.069,0.186) < .0001
 50 ≤ Age < 65 24,308 144 110,258.86 1.306 1 (Ref.)   1 (Ref.)  
 65 ≤ Age ≤ 75 1688 25 6550.21 3.8167 3.089 (2.019, 4.726)   2.995 (1.948,4.603)  
 75 < Age 28 1 76.54 13.0646 12.92 (1.803,92.597)   13.851 (1.918,100.017)  
Aspirin 1776 13 8017.85 1.62138 2.3 (1.309,4.04) 0.0038 1.295 (0.722,2.324) 0.3863
Statin 8701 37 39,075.1 0.94689 1.364 (0.952,1.955) 0.0905 1.32 (0.774,2.254) 0.3082
Duration of Immunosuppressant agent (> 300 days) 11,338 78 57,837.55 1.3486 2.345 (1.754,3.134)  < 0.001 3.504 (1.345,9.129) 0.0084
Hypertension 15,511 80 72,050.92 1.11033 1.878 (1.407,2.508)  < 0.001 1.347 (0.971,1.87) 0.0746
Diabetes mellitus 9504 64 44,114.7 1.45076 2.461 (1.82,3.328)  < 0.001 1.198 (0.839,1.71) 0.3202
Dyslipidemia 8546 29 37,485.7 0.77363 1.073 (0.722,1.595) 0.7258 0.632 (0.353,1.131) 0.122
Transplanted organ         
 Control 38,910 111 190,764.2 0.58187 1 (Ref.)  < .0001 1 (Ref.) 0.0271
 1. Kidney 7026 21 33,615.34 0.62471 1.08 (0.677,1.722)   0.319 (0.11,0.922)  
 2. Liver 5445 54 25,616.58 2.10801 3.661 (2.645,5.068)   0.838 (0.314,2.24)  
 3. Pancreas 28 0 105.38 0 N.A   N.A  
 4. Heart 398 2 1760.07 1.13632 2.013 (0.497,8.151)   0.37 (0.068,2.03)  
 5. Lung 73 0 233.99 0 N.A   N.A  
  1. N.A not available