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Table 3 Effects of crocin (6.25–100 mg/kg) on the seminiferous tubule area and germinal layer area

From: The protective effect of crocin on cisplatin-induced testicular impairment in rats

Groups SA (µm2)  × 103 EA area (µm2) × 103 EA/SA * 100
Control 44.61 ± 8.10 35.32 ± 4.75 81.93 ± 8.89
CIS (7 mg/kg) 43.08 ± 2.94 25.89 ± 4.70*** 59.08 ± 12.07**
CIS + CR6.25 mg/kg 42.53 ± 5.03 22.56 ± 4.18*** 56.35 ± 8.19**
CIS + CR25 mg/kg 43.31 ± 5.12 23.96 ± 3.80*** 59.48 ± 13.78**
CIS + CR100 mg/kg 44.83 ± 6.61 33.59 ± 6.40# 69.38 ± 10.98* #
  1. Values are expressed as mean ± standard deviation (n = 10). CIS: cisplatin; CR: crocin; CIS + CR 6.25–100: cisplatin (7 mg/kg) injected groups treated with 6.25–100 mg/kg crocin; SA: seminiferous tubule area; EA: germinal layer area. *p < 0.05, **p < 0.01 and ***p < 0.001 in comparison with the normal control group. #p < 0.05, ##p < 0.01 and ###p < 0.001 in comparison with the CIS group