Predictors | AUC of individual predictor variable (95% CI); P value* | Bivariate analysis OR(95%CI); P value | Multivariate analysis | ||
---|---|---|---|---|---|
Base model ** OR (95%CI); P value | Base model + %p2PSA OR (95%CI); P value | Base model + PHI OR (95%CI); P value | |||
Age | 0.66 (0.57–0.74) 0.470 | 1.077 (1.03–1.13); 0.002 | 1.063 (1.01–1.12); 0.014 | 1.070 (1.02–1.13); 0.011 | 1.068 (1.01–1.13); 0.013 |
tPSA, ng/mL | 0.63 (0.54 − 0.71) - | 1.100 (1.04–1.16); 0.001 | 1.064 (0.96–1.18); 0.252 | 1.049 (0.95 − 1.16); 0.335 | 1.013 (0.93–1.10); 0.761 |
fPSA | 0.57 (0.48–0.65) 0.117 | 1.543 (1.06–2.25); 0.024 | 1.036 (0.51–2.10); 0.921 | 1.012 (0.52–1.97); 0.971 | 0.886 (0.48–1.65); 0.701 |
%fPSA | 0.69 (0.61–0.77) 0.203 | 0.927 (0.88–0.98); 0.004 | 0.943 (0.87–1.03); 0.181 | 0.947 (0.87–1.03); 0.193 | 0.959 (0.89–1.04); 0.294 |
p2PSA, pg/mL | 0.69 (0.60–0.76) 0.157 | 1.021 (1.01–1.04); 0.001 | – | – | – |
%p2PSA | 0.72 (0.63–0.78) 0.109 | 1.708 (1.31–2.22); < 0.001 | – | 1.550 (1.18–2.04); 0.002 | – |
PHI | 0.76 (0.67–0.82) 0.005 | 1.017 (1.01–1.02); < 0.001 | – | – | 1.015 (1.01–1.02); 0.002 |
AUC of multivariate models (95% CI); | – | – | 0.736 (0.66–0.81) < 0.001 | 0.793 (0.72–0.86) < 0.001 | 0.796 (0.72–0.86) < 0.001 |
Gain in predictive accuracy (95% CI); P value | – | – | – | 0.056 (− 0.0–0.11); 0.058 | 0.060 (0.00–0.12); 0.037 |