Fig. 3

Time course of IT baclofen effect on spinal dorsal horn neuronal responses to UBD. Graph depict the rapid onset and duration of a single 160 ng dose of IT baclofen or IT normal saline applied topically to the dorsal surface of the spinal cord on repeated neuronal responses to urinary bladder distension (60 mm Hg, 20 s, every 3 min) normalized as percentage of pre-drug responses. See text for more complete description. N = 10/group. *, **p < 0.05 and p < 0.01 respectively for post hoc comparisons with IT saline-treated rats