Skip to main content

Table 3 Dose-dependent effects of cumulative doses of baclofen on visceromotor responses to urinary bladder distension measured as % baseline AUC in rats which received 7 day IT baclofen (20 ng/h) or IT saline infusions prior to testing

From: Systemic and intrathecal baclofen produce bladder antinociception in rats

Cumulative dose IT Pretreament
7 day infusion of baclofen IT (n = 7) 7 day infusion of saline IT (n = 6)
Baclofen 10 ng 112.5 ± 19.4 102.1 ± 13.9
Baclofen 20 ng 115.5 ± 20.3 83.6 ± 14.7
Baclofen 40 ng 57.4 ± 17.2 53.8 ± 15.5
Baclofen 80 ng 28.3 ± 9.5 17.5 ± 8.1
Baclofen 160 ng 11.2 ± 5.6 2.2 ± 0.8
  1. Data represents mean ± SEM. AUC indicates Area-Under-the-Curve, a statistic describing vigor of visceromotor responses to graded urinary bladder distension (10–60 mm Hg, 20 s). See text for more complete description. There were no statistically significant differences between Baclofen-Infused and Saline-Infused rats. All rats had received Neonatal Bladder Inflammation and Adult Bladder Inflammation pretreatments