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Table 3 Dose-dependent effects of cumulative doses of baclofen on visceromotor responses to urinary bladder distension measured as % baseline AUC in rats which received 7 day IT baclofen (20 ng/h) or IT saline infusions prior to testing

From: Systemic and intrathecal baclofen produce bladder antinociception in rats

Cumulative dose IT

Pretreament

7 day infusion of baclofen IT (n = 7)

7 day infusion of saline IT (n = 6)

Baclofen 10 ng

112.5 ± 19.4

102.1 ± 13.9

Baclofen 20 ng

115.5 ± 20.3

83.6 ± 14.7

Baclofen 40 ng

57.4 ± 17.2

53.8 ± 15.5

Baclofen 80 ng

28.3 ± 9.5

17.5 ± 8.1

Baclofen 160 ng

11.2 ± 5.6

2.2 ± 0.8

  1. Data represents mean ± SEM. AUC indicates Area-Under-the-Curve, a statistic describing vigor of visceromotor responses to graded urinary bladder distension (10–60 mm Hg, 20 s). See text for more complete description. There were no statistically significant differences between Baclofen-Infused and Saline-Infused rats. All rats had received Neonatal Bladder Inflammation and Adult Bladder Inflammation pretreatments
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BMC Urology

ISSN: 1471-2490

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