|
Sex, female (vs. male)
|
1.014 (0.503–2.042)
|
0.969
|
1.065 (0.532–2.134)
|
0.859
|
|
Age, y ≥ 65 (vs. < 65)
|
1.776 (0.953–3.309)
|
0.055
|
1.265 (0.738–2.167)
|
0.392
|
|
Grade, high (vs. low)
|
2.924 (1.398–6.117)
|
0.004
|
2.547 (1.307–4.963)
|
0.006
|
|
T stage, Ta
|
1
|
< 0.001
|
1
|
0.012
|
|
T1
|
1.372 (0.419–4.497)
|
0.601
|
0.916 (0.361–2.323)
|
0.854
|
|
T2–4
|
5.054 (1.55–16.475)
|
0.007
|
1.842 (0.717–4.729)
|
0.204
|
|
N stage, N1-3 (vs. N0)
|
5.832 (2.575–13.211)
|
< 0.001
|
3.087 (1.319–7.227)
|
0.009
|
|
M stage, M1 (vs. M0)
|
7.814 (3.038–20.096)
|
< 0.001
|
0.894 (0.123–6.48)
|
0.912
|
|
TNM stage, Stage 0
|
1
|
< 0.001
|
1
|
0.027
|
|
Stage I
|
1.374 (0.419–4.503)
|
0.6
|
0.916 (0.362–2.323)
|
0.916
|
|
Stage II, III
|
4.625 (1.41–15.177)
|
0.012
|
1.88 (0.731–4.835)
|
0.19
|
|
Stage IV
|
17.793 (4.119–76.872)
|
< 0.001
|
1.085 (0.126–9.368)
|
0.879
|
|
FAM83H, positive (vs. negative)
|
3.423 (1.748–6.704)
|
< 0.001
|
3.83 (2.06–7.121)
|
< 0.001
|
|
Nectin1, positive (vs. negative)
|
2.48 (1.415–4.346)
|
0.002
|
2.475 (1.469–4.169)
|
0.001
|
|
Combined expression, FAM83H−/Nectin1−
|
1
|
0.001
|
1
|
< 0.001
|
|
FAM83H−/Nectin1+ or FAM83H+/Nectin1−
|
3.89 (1.424–10.624)
|
0.008
|
3.36 (1.392–8.11)
|
0.007
|
|
FAM83H+/Nectin1+
|
5.579 (2.216–14.046)
|
< 0.001
|
5.309 (2.402–11.735)
|
< 0.001
|
