Skip to main content

Table 3 Univariate Cox proportional hazards regression analysis for overall survival and relapse-free survival in non-invasive high-grade and invasive bladder urothelial carcinomas

From: FAM83H and Nectin1 expression are related with survival and relapse of bladder urothelial carcinoma patients

Characteristics OS RFS
HR (95% CI) p HR (95% CI) p
Sex, female (vs. male) 1.014 (0.503–2.042) 0.969 1.065 (0.532–2.134) 0.859
Age, y ≥ 65 (vs. < 65) 1.776 (0.953–3.309) 0.055 1.265 (0.738–2.167) 0.392
Grade, high (vs. low) 2.924 (1.398–6.117) 0.004 2.547 (1.307–4.963) 0.006
T stage, Ta 1  < 0.001 1 0.012
 T1 1.372 (0.419–4.497) 0.601 0.916 (0.361–2.323) 0.854
 T2–4 5.054 (1.55–16.475) 0.007 1.842 (0.717–4.729) 0.204
N stage, N1-3 (vs. N0) 5.832 (2.575–13.211)  < 0.001 3.087 (1.319–7.227) 0.009
M stage, M1 (vs. M0) 7.814 (3.038–20.096)  < 0.001 0.894 (0.123–6.48) 0.912
TNM stage, Stage 0 1  < 0.001 1 0.027
 Stage I 1.374 (0.419–4.503) 0.6 0.916 (0.362–2.323) 0.916
 Stage II, III 4.625 (1.41–15.177) 0.012 1.88 (0.731–4.835) 0.19
 Stage IV 17.793 (4.119–76.872)  < 0.001 1.085 (0.126–9.368) 0.879
FAM83H, positive (vs. negative) 3.423 (1.748–6.704)  < 0.001 3.83 (2.06–7.121)  < 0.001
Nectin1, positive (vs. negative) 2.48 (1.415–4.346) 0.002 2.475 (1.469–4.169) 0.001
Combined expression, FAM83H−/Nectin1− 1 0.001 1  < 0.001
 FAM83H−/Nectin1+ or FAM83H+/Nectin1− 3.89 (1.424–10.624) 0.008 3.36 (1.392–8.11) 0.007
 FAM83H+/Nectin1+ 5.579 (2.216–14.046)  < 0.001 5.309 (2.402–11.735)  < 0.001