FAM83H and Nectin1 expression are related with survival and relapse of bladder urothelial carcinoma patients

BMC Urology

Table 4 Multivariate Cox regression analysis for overall survival in non-invasive high-grade and invasive bladder urothelial carcinomas

Characteristics	OS
Characteristics	HR (95% CI)	p
Model 1^a
T stage, Ta	1	< 0.001
T1	1.647 (0.501–5.411)	0.411
T2-4	4.78 (1.434–15.932)	0.011
N stage, N1-3 (vs. N0)	2.774 (1.185–6.492)	0.019
M stage, M1 (vs. M0)	3.435 (1.291–9.142)	0.013
FAM83H positive (vs. negative)	3.141 (1.587–6.215)	0.001
Model 2^b
T stage, Ta	1	< 0.001
T1	1.831 (0.556–6.025)	0.32
T2-4	5.76 (1.707–19.436)	0.005
N stage, N1-3 (vs. N0)	2.382 (1.016–5.586)	0.046
M stage, M1 (vs. M0)	3.428 (1.277–9.196)	0.014
Combined expression, FAM83H−/Nectin1−	1	0.002
FAM83H−/Nectin1+ or FAM83H+/Nectin1−	4.731 (1.7–13.163)	0.003
FAM83H+/Nectin1+	5.46 (2.144–13.905)	< 0.001

OS overall survival, HR hazard ratio, 95% CI 95% confidence interval
^aVariables considered in model 1 were histologic grade, T stage, N stage, M stage, TNM stage, FAM83H expression, and Nectin1 expression
^bVariables considered in model 2 were histologic grade, T stage, N stage, M stage, TNM stage, and combined expression of FAM83H and Nectin1

ISSN: 1471-2490