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Table 4 Multivariate Cox regression analysis for overall survival in non-invasive high-grade and invasive bladder urothelial carcinomas

From: FAM83H and Nectin1 expression are related with survival and relapse of bladder urothelial carcinoma patients

Characteristics OS
HR (95% CI) p
Model 1a   
T stage, Ta 1  < 0.001
T1 1.647 (0.501–5.411) 0.411
T2-4 4.78 (1.434–15.932) 0.011
N stage, N1-3 (vs. N0) 2.774 (1.185–6.492) 0.019
M stage, M1 (vs. M0) 3.435 (1.291–9.142) 0.013
FAM83H positive (vs. negative) 3.141 (1.587–6.215) 0.001
Model 2b   
T stage, Ta 1  < 0.001
T1 1.831 (0.556–6.025) 0.32
T2-4 5.76 (1.707–19.436) 0.005
N stage, N1-3 (vs. N0) 2.382 (1.016–5.586) 0.046
M stage, M1 (vs. M0) 3.428 (1.277–9.196) 0.014
Combined expression, FAM83H−/Nectin1− 1 0.002
 FAM83H−/Nectin1+ or FAM83H+/Nectin1− 4.731 (1.7–13.163) 0.003
 FAM83H+/Nectin1+ 5.46 (2.144–13.905)  < 0.001
  1. OS overall survival, HR hazard ratio, 95% CI 95% confidence interval
  2. aVariables considered in model 1 were histologic grade, T stage, N stage, M stage, TNM stage, FAM83H expression, and Nectin1 expression
  3. bVariables considered in model 2 were histologic grade, T stage, N stage, M stage, TNM stage, and combined expression of FAM83H and Nectin1