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Table 5 Multivariate Cox regression analysis for relapse-free survival in non-invasive high-grade and invasive bladder urothelial carcinomas

From: FAM83H and Nectin1 expression are related with survival and relapse of bladder urothelial carcinoma patients

  RFS
  HR (95% CI) p
Model 1a   
TNM stage, Stage 0 1 0.067
 Stage I 1.075 (0.423–2.729) 0.88
 Stage II, III 1.983 (0.77–5.106) 0.156
 Stage IV 0.906 (0.105–7.837) 0.929
FAM83H positive (vs. negative) 3.691 (1.977–6.889)  < 0.001
Model 2b   
TNM stage, Stage 0 1 0.037
 Stage I 1.175 (0.871–3.021) 0.738
 Stage II, III 2.305 (0.871–6.1) 0.093
 Stage IV 1.106 (0.128–9.584) 0.927
Combined expression, FAM83H−/Nectin1− 1  < 0.001
 FAM83H−/Nectin1+ or FAM83H+/Nectin1− 3.877 (1.582–9.502) 0.003
 FAM83H+/Nectin1+ 5.272 (2.377–11.693) < 0.001
  1. RFS relapse free survival, HR hazard ratio, 95% CI 95% confidence interval
  2. aVariables considered in model 1 were histologic grade, T stage, N stage, TNM stage, FAM83H expression, and Nectin1 expression
  3. bVariables considered in model 2 were histologic grade, T stage, N stage, TNM stage, and combined expression of FAM83H and Nectin1