Free combination therapy versus dutasteride monotherapy | Free combination therapy versus tamsulosin monotherapy | |||||
---|---|---|---|---|---|---|
Free combination of dutasteride plus tamsulosin therapy (n = 1527) | Dutasteride monotherapy (n = 6661) | Std. diff* (%) | Free combination of dutasteride plus tamsulosin therapy (n = 1544) | Tamsulosin monotherapy (n = 6574) | Std. diff* (%) | |
Age, n (%) | ||||||
40–49 years | 29 (1.9) | 150 (2.2) | 2.3 | 20 (1.3) | 90 (1.4) | 0.7 |
50–59 years | 165 (10.8) | 704 (10.6) | 0.8 | 182 (11.8) | 777 (11.8) | 0.2 |
60–69 years | 488 (32.0) | 2133 (32.0) | 0.1 | 517 (33.5) | 2201 (33.5) | 0.0 |
≥ 70 years | 844 (55.3) | 3675 (55.2) | 0.3 | 826 (53.5) | 3506 (53.3) | 0.3 |
Clinical characteristics, n (%) | ||||||
Any AE† | 422 (27.7) | 1857 (27.9) | 0.5 | 476 (30.8) | 2030 (30.9) | 0.1 |
Cardiovascular disease‡ | 565 (37.0) | 2475 (37.2) | 0.3 | 622 (40.3) | 2612 (39.7) | 1.2 |
Hyperlipidemia | 304 (19.9) | 1361 (20.4) | 1.3 | 338 (21.9) | 1433 (21.8) | 0.3 |
Chronic pulmonary disease | 221 (14.5) | 988 (14.8) | 0.9 | 258 (16.7) | 1088 (16.5) | 0.4 |
BPH with LUTS | 210 (13.7) | 889 (13.3) | 1.1 | 288 (18.6) | 1193 (18.2) | 1.2 |
Polyuria§ | 167 (10.9) | 709 (10.6) | 1.0 | 225 (14.6) | 936 (14.2) | 1.0 |
Concomitant medications, n (%) | ||||||
NSAIDs | 530 (34.7) | 2302 (34.6) | 0.4 | 585 (37.9) | 2417 (36.8) | 2.3 |
Calcium channel blockers | 330 (21.6) | 1400 (21.0) | 1.4 | 374 (24.2) | 1500 (22.8) | 3.3 |
Antihypertensives | 334 (21.9) | 1454 (21.8) | 0.1 | 361 (23.4) | 1459 (22.2) | 2.8 |