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Table 2 Safety after mirabegron treatment (n = 41)

From: Mirabegron for overactive bladder in frail patients 80 years or over (HOKUTO study)

  Baseline Week 4 Week 8 Week 12
Heart rate (beats/min) 64 (57–73)    63.5 (58–77)
QTcF (ms) 419 (397.25–438)    415 (401.25–433.25)
MMSE 27 (25–28) 26.5 (24.25–29) 28 (26–29) 27 (26–29.5)
VES-13 6 (3–8) 5 (4–7) 4# (2–5.25) 3* (2.25–6)
VES-13 excluding age 3.5 (1–6) 3 (1–6) 1# (1–3) 1# (1–4)
  1. Median (IQR)
  2. *P < 0.05; #P < 0.01 (vs. baseline)