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Table 2 The risk factors of intravesical recurrence in patients with histopathologically diagnosed T1 HG bladder cancers

From: Biological distinction between grades 2 and 3 with respect to intravesical recurrence in T1 high-grade bladder tumors: a retrospective study

Variable Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
Sex       
 Male 1      
 Female 1.23 0.70–2.14 0.4675    
Age       
 < 70 1      
 70 1.12 0.69–1.82 0.6423    
Number of tumors       
 Single 1    1   
 Multiple 1.81 1.07–3.05 0.0276 2.77 1.57–4.90 0.0005
Maximum diameter       
 < 3 cm 1    1   
 3 cm 1.15 0.62–2.15 0.6506 0.84 0.44–1.61 0.5982
History of recurrence       
 Primary 1    1   
 Recurrent 1.16 0.71–1.90 0.5576 1.29 0.75–2.21 0.3541
Concomitant CIS       
 No 1    1   
 Yes 0.91 0.53–1.56 0.7262 1.66 0.86–3.18 0.1301
Second TURBT       
 No 1    1   
 Yes 0.72 0.45–1.16 0.1728 1.72 0.94–3.15 0.0771
WHO grade 1973 and Ins       
 (1) G2 and G3 with Ins ref    ref   
 (2) G2 without Ins 4.22 2.42–7.38 < 0.0001 9.60 4.39–21.0 < 0.0001
 (3) G3 without Ins 2.41 1.35–4.28 0.0028 3.26 1.72–6.19 0.0003
  1. HG high grade, HR hazard ratio, CI confidence interval, CIS carcinoma in situ, TURBT transurethral resection of bladder tumor, WHO World Health Organization, G2 grade 2, G3 grade 3, Ins intravesical instillation therapy