|
Variable
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
HR
|
95% CI
|
p value
|
HR
|
95% CI
|
p value
|
|---|
|
Sex
| | | | | | |
|
Male
|
1
| | | | | |
|
Female
|
1.23
|
0.70–2.14
|
0.4675
| | | |
|
Age
| | | | | | |
|
< 70
|
1
| | | | | |
| ≧ 70 |
1.12
|
0.69–1.82
|
0.6423
| | | |
|
Number of tumors
| | | | | | |
|
Single
|
1
| | |
1
| | |
|
Multiple
|
1.81
|
1.07–3.05
|
0.0276
|
2.77
|
1.57–4.90
|
0.0005
|
|
Maximum diameter
| | | | | | |
|
< 3 cm
|
1
| | |
1
| | |
| ≧ 3 cm |
1.15
|
0.62–2.15
|
0.6506
|
0.84
|
0.44–1.61
|
0.5982
|
|
History of recurrence
| | | | | | |
|
Primary
|
1
| | |
1
| | |
|
Recurrent
|
1.16
|
0.71–1.90
|
0.5576
|
1.29
|
0.75–2.21
|
0.3541
|
|
Concomitant CIS
| | | | | | |
|
No
|
1
| | |
1
| | |
|
Yes
|
0.91
|
0.53–1.56
|
0.7262
|
1.66
|
0.86–3.18
|
0.1301
|
|
Second TURBT
| | | | | | |
|
No
|
1
| | |
1
| | |
|
Yes
|
0.72
|
0.45–1.16
|
0.1728
|
1.72
|
0.94–3.15
|
0.0771
|
|
WHO grade 1973 and Ins
| | | | | | |
|
(1) G2 and G3 with Ins
|
ref
| | |
ref
| | |
|
(2) G2 without Ins
|
4.22
|
2.42–7.38
|
< 0.0001
|
9.60
|
4.39–21.0
|
< 0.0001
|
|
(3) G3 without Ins
|
2.41
|
1.35–4.28
|
0.0028
|
3.26
|
1.72–6.19
|
0.0003
|
- HG high grade, HR hazard ratio, CI confidence interval, CIS carcinoma in situ, TURBT transurethral resection of bladder tumor, WHO World Health Organization, G2 grade 2, G3 grade 3, Ins intravesical instillation therapy
