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Table 2 The risk factors of intravesical recurrence in patients with histopathologically diagnosed T1 HG bladder cancers

From: Biological distinction between grades 2 and 3 with respect to intravesical recurrence in T1 high-grade bladder tumors: a retrospective study

Variable

Univariate analysis

Multivariate analysis

HR

95% CI

p value

HR

95% CI

p value

Sex

      

 Male

1

     

 Female

1.23

0.70–2.14

0.4675

   

Age

      

 < 70

1

     

≧ 70

1.12

0.69–1.82

0.6423

   

Number of tumors

      

 Single

1

  

1

  

 Multiple

1.81

1.07–3.05

0.0276

2.77

1.57–4.90

0.0005

Maximum diameter

      

 < 3 cm

1

  

1

  

≧ 3 cm

1.15

0.62–2.15

0.6506

0.84

0.44–1.61

0.5982

History of recurrence

      

 Primary

1

  

1

  

 Recurrent

1.16

0.71–1.90

0.5576

1.29

0.75–2.21

0.3541

Concomitant CIS

      

 No

1

  

1

  

 Yes

0.91

0.53–1.56

0.7262

1.66

0.86–3.18

0.1301

Second TURBT

      

 No

1

  

1

  

 Yes

0.72

0.45–1.16

0.1728

1.72

0.94–3.15

0.0771

WHO grade 1973 and Ins

      

 (1) G2 and G3 with Ins

ref

  

ref

  

 (2) G2 without Ins

4.22

2.42–7.38

< 0.0001

9.60

4.39–21.0

< 0.0001

 (3) G3 without Ins

2.41

1.35–4.28

0.0028

3.26

1.72–6.19

0.0003

  1. HG high grade, HR hazard ratio, CI confidence interval, CIS carcinoma in situ, TURBT transurethral resection of bladder tumor, WHO World Health Organization, G2 grade 2, G3 grade 3, Ins intravesical instillation therapy
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