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Table 2 Univariate Cox regression analysis of clinical factors in patients with metastatic renal cell carcinoma

From: Prognostic value of the ratio of maximum to minimum diameter of primary tumor in metastatic clear cell renal cell carcinoma

Variable

Progression free survival

Overall survival

HR

95% CI

p value

HR

95% CI

p value

Age

1.003

0.988–1.019

0.653

1.001

0.985–1.018

0.871

Gender, male

0.936

0.677–1.293

0.688

0.829

0.586–1.173

0.290

KPS, < 80

1.064

0.520–2.177

0.864

0.577

0.212–1.569

0.281

Presenting symptom

1.292

0.770–2.168

0.332

2.256

1.247–4.082

0.007

Tumor location, left

1.027

0.753–1.400

0.867

1.073

0.769–1.497

0.678

ROD, ≥ 1.34

3.974

2.784–5.673

 < 0.001

2.783

1.927–4.018

 < 0.001

Number of metastatic organs, ≥ 2

1.053

0.728–1.547

0.468

0.459

0.592–1.426

0.584

pT stage, 3/4

1.021

0.677–1.676

0.061

1.025

0.823–1.312

0.078

WHO/ISUP grade, III/IV

2.308

1.684–3.165

 < 0.001

3.164

2.249–4.415

 < 0.001

Tumor necrosis

1.438

1.031–2.007

0.032

1.677

1.167–2.410

0.007

Sarcomatoid differentiation

2.131

1.455–3.120

 < 0.001

1.722

1.107–2.680

0.016

MSKCC score, intermediate and poor

2.624

1.895–3.634

 < 0.001

3.125

2.174–4.493

 < 0.001

IMDC score, intermediate and poor

3.342

2.116–6.528

 < 0.001

4.317

2.383–6.657

 < 0.001

  1. KPS Karnofsky performance status ROD Ratio of maximum to minimum tumor diameter, WHO/ISUP World Health Organization/International Society of Urologic Pathologists, MSKCC Memorial Sloan Kettering Cancer Center, IMDC International Metastatic Renal Cell Carcinoma Database Consortium