Fig. 2From: Clinicopathologic, treatment and prognosis study of 46 Xp11.2 translocation/TFE3 gene fusion renal cell carcinomasRepresentative pathologic image of Xp11.2 translocation RCC. A Tumour composed of clear and eosinophilic cells with psammoma bodies. B A neoplasm with a tubular and papillary structures. C Tumour cells with clear cytoplasm formed tubules with abundant psammoma bodies resembling a clear cell renal cell carcinoma. D Diffuse nuclear staining was detected. E The nucleus showed diffuse, strong staining for TFE3. F The demonstration of TFE3 gene rearrangement by FISH. One fused signal (yellow arrow) and two split signals (green and red arrow). (A–C Magnification: × 40; D–E Magnification: × 100; F: Magnification: × 1000)Back to article page