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Table 2 Clinical trends after treatment

From: Neoadjuvant versus adjuvant chemotherapy in upper tract urothelial carcinoma: A nationwide cohort study

 

                                                               Before matching

 

                                                              After matching

 

AC

NAC

p-value

 

AC

(n = 188)

NAC

(n = 94)

p-value

 

(n = 1984)

(n = 94)

   
 

Mean ± SD

Median [Q1; Q3]

Mean ± SD

Median [Q1; Q3]

  

Mean ± SD

Median [Q1; Q3]

Mean ± SD

Median [Q1; Q3]

 

Period from NUx to ST (months)

1.2 ± 0.5

1.1 [ 0.9; 1.4]

4.8 ± 3.0

4.0 [ 2.6; 6.1]

< 0.001

 

1.2 ± 0.5

1.1 [ 0.9; 1.4]

4.8 ± 3.0

4.0 [ 2.6; 6.1]

< 0.001

Hospitalization duration at NUx (days)

13.2 ± 6.3

11.0 [10.0;15.0]

14.1 ± 8.6

12.0 [10.0;16.0]

0.323

 

12.7 ± 6.0

11.0 [ 9.0;15.0]

14.1 ± 8.6

12.0 [10.0;16.0]

0.148

3-months readmission rate after NUx (%)

    

0.063

     

0.502

- No

1451 (73.1%)

 

60 (63.8%)

   

129 (68.6%)

 

60 (63.8%)

  

- Yes

533 (26.9%)

 

34 (36.2%)

   

59 (31.4%)

 

34 (36.2%)

  

Transfusion at NUx (%)

    

< 0.001

     

< 0.001

- No

1206 (60.8%)

 

35 (37.2%)

   

122 (64.9%)

 

35 (37.2%)

  

- Yes

778 (39.2%)

 

59 (62.8%)

   

66 (35.1%)

 

59 (62.8%)

  

Volume of transfusion at NUx (packs)

3.3 ± 2.6

2.0 [ 2.0; 4.0]

3.2 ± 2.0

2.0 [ 2.0; 4.0]

0.872

 

3.6 ± 3.0

3.0 [ 2.0; 4.0]

3.2 ± 2.0

2.0 [ 2.0; 4.0]

0.678

G-CSF usage rate (%)

    

< 0.001

     

0.004

- No

1272 (64.1%)

 

79 (84.0%)

   

126 (67.0%)

 

79 (84.0%)

  

- Yes

712 (35.9%)

 

15 (16.0%)

   

62 (33.0%)

 

15 (16.0%)

  

The number of G-CSF usage, during ST

2.7 ± 3.0

2.0 [ 1.0; 3.0]

2.1 ± 1.9

1.0 [ 1.0; 2.5]

0.445

 

2.4 ± 2.0

2.0 [ 1.0; 3.0]

2.1 ± 1.9

1.0 [ 1.0; 2.5]

0.603

The number of G-CSF usage, during total period

2.8 ± 3.1

2.0 [ 1.0; 3.0]

2.3 ± 1.8

2.0 [ 1.0; 3.0]

  

2.6 ± 2.2

2.0 [ 1.0; 3.0]

2.3 ± 1.8

2.0 [ 1.0; 3.0]

0.558

The rate of G-CSF usage within 3-months (%)

    

0.182

     

0.147

- No

1659 (83.6%)

 

84 (89.4%)

   

154 (81.9%)

 

84 (89.4%)

  

- Yes

325 (16.4%)

 

10 (10.6%)

   

34 (18.1%)

 

10 (10.6%)

  

Dialysis after NUx

    

0.278

     

0.398

- No

1895 (95.5%)

 

87 (92.6%)

   

180 (95.7%)

 

87 (92.6%)

  

- Yes

89 (4.5%)

 

7 (7.4%)

   

8 (4.3%)

 

7 (7.4%)

  

Preoperative URS biopsy (%)

    

< 0.001

     

0.006

- No

1658 (83.6%)

 

65 (69.1%)

   

158 (84.0%)

 

65 (69.1%)

  

- Yes

326 (16.4%)

 

29 (30.9%)

   

30 (16.0%)

 

29 (30.9%)

  

Preoperative TUR-BT (%)

    

< 0.001

     

< 0.001

- No

1759 (88.7%)

 

64 (68.1%)

   

166 (88.3%)

 

64 (68.1%)

  

- Yes

225 (11.3%)

 

30 (31.9%)

   

22 (11.7%)

 

30 (31.9%)

  

TUR-BT after NUx (%)

    

0.866

     

1.000

- No

1472 (74.2%)

 

71 (75.5%)

   

141 (75.0%)

 

71 (75.5%)

  

- Yes

512 (25.8%)

 

23 (24.5%)

   

47 (25.0%)

 

23 (24.5%)

  

Period from NUx to TUR-BT (months)

17.4 ± 16.4

12.2 [ 8.4;21.0]

15.1 ± 16.8

10.0 [ 3.9;15.0]

0.523

 

15.6 ± 13.1

12.2 [ 7.8;21.6]

15.1 ± 16.8

10.0 [ 3.9;15.0]

0.910

The rate of radiotherapy (%)

    

0.860

     

0.497

- No

1750 (88.2%)

 

84 (89.4%)

   

174 (92.6%)

 

84 (89.4%)

  

- Yes

234 (11.8%)

 

10 (10.6%)

   

14 (7.4%)

 

10 (10.6%)

  
  1. Abbreviations: AC, Adjuvant chemotherapy; NAC, Neoadjuvant chemotherapy; SD, Standard Deviation; NUx, Nephroureterectomy; ST, systemic therapy;
  2. G-CSF, Granulocyte Colony Stimulating Factor; URS, ureterorenoscopy; TUR-BT, Transurethral resection of bladder tumor