Parameter | Cutoff | Univariate | Multivariate | ||
---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||
Age (years) | Continuous | 1.01 (0.99–1.04) per score | 0.31 | ||
Sex | Male | Reference | 0.62 | ||
Female | 0.86 (0.47–1.53) | ||||
ECOG PS | 0 | Reference | 0.019* | Reference | 0.013* |
≥ 1 | 1.89 (1.09–3.17) | 2.04 (1.14–3.56) | |||
eGFR (mL/min/1.73 m2) | < 60 | Reference | 0.57 | ||
≥ 60 | 1.16 (0.68–1.93) | ||||
Primary site | Bladder | Reference | |||
Upper urinary tract | 1.12 (0.65–1.96) | ||||
Both | 1.70 (0.79–3.42) | ||||
Resection of primary site | No | Reference | 0.0039* | Reference | 0.067 |
Yes | 0.48 (0.29–0.79) | 0.61 (0.36–1.03) | |||
Prior neoadjuvant/adjuvant chemotherapy | No | Reference | 0.47 | ||
Yes | 1.30 (0.60–2.51) | ||||
Lymph node metastasis | No | Reference | 0.020* | Reference | 0.0019* |
Yes | 1.91 (1.13–3.39) | 2.51 (1.43–4.58) | |||
Lung metastasis | No | Reference | 0.62 | ||
Yes | 0.88 (0.51–1.46) | ||||
Bone metastasis | No | Reference | 0.79 | ||
Yes | 1.10 (0.52–2.07) | ||||
Liver metastasis | No | Reference | 0.021* | Reference | 0.0045* |
Yes | 2.16 (1.07–3.99) | 2.71 (1.30–5.23) | |||
First-line regimens | Full-dose GC | Reference | 0.37 | ||
Dose-reduced GC | 1.03 (0.52–1.95) | ||||
GCa | 1.45 (0.82–2.56) |