Fig. 4
From: The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk
The prognosis of kidney, bladder and prostate cancer patients was affected by the pathogenicity of germline mutations. Significantly better overall survival was observed in non-pathogenic group (green lines) compared with pathogenic (orange lines) or likely pathogenic group (blue lines) in kidney, bladder and prostate cancer (A), and in subtypes of kidney cancer, including KIRC and KIRP (B). P values for each cancer are labeled. The P values between any two subgroups are listed below: kidney cancer (P vs. LP = 0.18; P vs. Non-P < 0.001; LP vs. Non-P < 0.001); bladder cancer (P vs. LP = 0.2024; P vs. Non-P = 0.0015; LP vs. Non-P = 0.0011); prostate cancer (P vs. LP = 0.81; P vs. Non-P < 0.001; LP vs. Non-P < 0.001); KICH (P vs. LP = 1.00; P vs. Non-P = 0.27; LP vs. Non-P = 1.00); KIRC (P vs. LP = 0.1108; P vs. Non-P = 0.0014; LP vs. Non-P < 0.001); KIRP (P vs. LP = 0.7304; P vs Non-P = 0.0004; LP vs. Non-P = 0.0004)