Table 2 The number of patients for each cancer type grouped by sex, variant type and pathogenicity
From: The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk
Factors | Categories | Cancer Types | P values | ||||
|---|---|---|---|---|---|---|---|
BLCA | KICH | KIRC | KIRP | PRAD | Â | ||
Sex (%) | Â | Â | Â | Â | Â | Â | Â |
|  | Female | 10 (20.8) | 2 (28.6) | 25 (56.8) | 9 (20.0) | 0 ( 0.0) | P = 0.00039(excl PRAD) |
|  | Male | 38 (79.2) | 5 (71.4) | 19 (43.2) | 36 (80.0) | 62 (100.0) | P < 0.001(incl PRAD) |
Variant_Type (%) | Â | Â | Â | Â | Â | Â | Â |
|  | stop_gained | 22 (45.8) | 0 ( 0.0) | 12 (27.3) | 14 (31.1) | 18 (29.0) | P = 0.37 |
| Â | frameshift_variant | 10 (20.8) | 4 (57.1) | 14 (31.8) | 14 (31.1) | 25 (40.3) | |
| Â | missense_variant | 11 (22.9) | 2 (28.6) | 13 (29.5) | 10 (22.2) | 10 (16.1) | |
| Â | Others | 5 (10.5) | 1 (14.3) | 5 (11.4) | 7 (15.6) | 9 (14.5) | |
Pathogenicity (%) | Â | Â | Â | Â | Â | Â | Â |
|  | Likely Pathogenic | 13 (27.1) | 2 (28.6) | 8 (18.2) | 14 (31.1) | 15 (24.2) | P = 0.74 |
| Â | NonPathogenic | 18 (37.5) | 3 (42.9) | 22 (50.0) | 19 (42.2) | 33 (53.2) | |
| Â | Pathogenic | 17 (35.4) | 2 (28.6) | 14 (31.8) | 12 (26.7) | 14 (22.6) | |
Number of patients | Â | 48 | 7 | 44 | 45 | 62 | |