Table 1 Demographics, clinicopathologic characteristics, and therapeutic information of the enrolled UTUC patients
Characteristics | Received chemotherapy | Unreceived chemotherapy | Total | P value |
|---|---|---|---|---|
(N = 4441) | (N = 1257) | (N = 5698) | ||
Age (years) | < 0.001* | |||
Mean (SD) | 72.1 (11.0) | 67.2 (10.4) | 71.1 (11.1) | |
Sex | 0.076 | |||
Female | 1943 (43.8%) | 514 (40.9%) | 2457 (43.1%) | |
Male | 2498 (56.2%) | 743 (59.1%) | 3241 (56.9%) | |
Race | < 0.001* | |||
White | 3887 (87.5%) | 1051 (83.6%) | 4938 (86.7%) | |
Black | 185 (4.2%) | 53 (4.2%) | 238 (4.2%) | |
Other | 369 (8.3%) | 153 (12.2%) | 522 (9.2%) | |
Marital status | < 0.001* | |||
Married | 2658 (59.9%) | 890 (70.8%) | 3548 (62.3%) | |
Divorced/widowed/Separated | 1363 (30.7%) | 248 (19.7%) | 1611 (28.3%) | |
Unmarried/Single | 420 (9.5%) | 119 (9.5%) | 539 (9.5%) | |
Primary Site | 0.358 | |||
Renal Pelvis | 2933 (66.0%) | 812 (64.6%) | 3745 (65.7%) | |
Ureter | 1508 (34.0%) | 445 (35.4%) | 1953 (34.3%) | |
Grade | < 0.001* | |||
Grade I | 246 (5.5%) | 21 (1.7%) | 267 (4.7%) | |
Grade II | 801 (18.0%) | 77 (6.1%) | 878 (15.4%) | |
Grade III | 1253 (28.2%) | 404 (32.1%) | 1657 (29.1%) | |
Grade IV | 2141 (48.2%) | 755 (60.1%) | 2896 (50.8%) | |
T Stage | < 0.001* | |||
T1 | 1642 (37.0%) | 177 (14.1%) | 1819 (31.9%) | |
T2 | 881 (19.8%) | 132 (10.5%) | 1013 (17.8%) | |
T3 | 1598 (36.0%) | 694 (55.2%) | 2292 (40.2%) | |
T4 | 320 (7.2%) | 254 (20.2%) | 574 (10.1%) | |
N Stage | < 0.001* | |||
N0 | 4123 (92.8%) | 779 (62.0%) | 4902 (86.0%) | |
N1 | 186 (4.2%) | 262 (20.8%) | 448 (7.9%) | |
N2 | 132 (3.0%) | 216 (17.2%) | 348 (6.1%) | |
M Stage | < 0.001* | |||
M0 | 4286 (96.5%) | 1024 (81.5%) | 5310 (93.2%) | |
M1 | 155 (3.5%) | 233 (18.5%) | 388 (6.8%) | |
Radiation | 1.000 | |||
No/Unknown | 19 (0.4%) | 6 (0.5%) | 25 (0.4%) | |
Yes | 4422 (99.6%) | 1251 (99.5%) | 5673 (99.6%) | |
Surgical methods of the primary site | < 0.001* | |||
No | 26 (0.6%) | 124 (9.9%) | 150 (2.6%) | |
Local Mass resection/destruction | 163 (3.7%) | 49 (3.9%) | 212 (3.7%) | |
Partial nephrectomy/ureterectomy | 472 (10.6%) | 114 (9.1%) | 586 (10.3%) | |
Radical nephroureterectomy | 2600 (58.5%) | 586 (46.6%) | 3186 (55.9%) | |
Radical nephrectomy | 1014 (22.8%) | 324 (25.8%) | 1338 (23.5%) | |
Multivisceral resection | 166 (3.7%) | 60 (4.8%) | 226 (4.0%) | |
Surgery of Lymph nodes (LNs) | < 0.001* | |||
No | 3413 (76.9%) | 716 (57.0%) | 4129 (72.5%) | |
1 to 3 regional LNs removed | 610 (13.7%) | 268 (21.3%) | 878 (15.4%) | |
4 or more regional LNs removed | 418 (9.4%) | 273 (21.7%) | 691 (12.1%) |