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Table 3 Multivariate Cox regression analyses on recurrence-free survival of urothelial carcinoma, intravesical recurrence and upper tract recurrence in patients with or without previous malignant history

From: Impact of previous malignancy at diagnosis on oncological outcomes of upper tract urothelial carcinoma

 

Urothelial carcinoma

Intravesical recurrence

Upper tract recurrence

 

HR(95% CI)

P value

HR(95% CI)

P value

HR(95% CI)

P value

Smoke

 

0.052

 

0.585

 

0.264

No

Reference

 

Reference

 

Reference

 

Yes

1.426

(0.996–2.041)

 

0.907

(0.639–1.287)

 

1.333

(0.805–2.205)

 

Gender

 

0.110

 

0.738

 

0.131

Female

Reference

 

Reference

 

Reference

 

Male

0.759

(0.541–1.064)

 

1.064

(0.739–1.531)

 

0.698

(0.437–1.113)

 

Previous malignancy

 

0.064

 

0.114

 

0.067

No

Reference

 

Reference

 

Reference

 

Yes

1.336

(0.984–1.814)

 

1.300

(0.939–1.799)

 

1.486

(0.972–2.273)

 

pT Stage

 

0.011*

 

0.685

 

0.111

Ta/Tis/T1

Reference

 

Reference

 

Reference

 

T2-4

1.605

(1.116–2.309)

 

1.079

(0.746–1.562)

 

0.648

(0.381–1.104)

 

Tumor Grade

 

0.436

 

0.401

 

0.019*

G1-2

Reference

 

Reference

 

Reference

 

G3

0.872

(0.617–1.231)

 

0.855

(0.594–1.232)

 

1.842

(1.103–3.075)

 
  1. CI = confidence interval; HR = hazard ratio;
  2. *p < 0.05; **p < 0.01; and ***p < 0.001