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Pre-clinical and basic research

Section edited by Prof. Kenneth Iczkowski 

This section considers articles describing all aspects of pre-clinical and basic research in the field of urology. This section covers a wide range of methodologies and study designs, including the identification of the molecular underpinnings of urological disease, and the application of this knowledge to clinical practice. Submissions describing clinical research should be directed to the sub-discipline specific sections.

  2. Peyronie’s disease (PD) is a severe fibrotic disease of the tunica albuginea that causes penis curvature and leads to penile pain, deformity, and erectile dysfunction. The role of pericytes in the pathogenesis...

    Authors: Guo Nan Yin, Shuguang Piao, Zhiyong Liu, Lei Wang, Jiyeon Ock, Mi-Hye Kwon, Do-Kyun Kim, Yong Song Gho, Jun-Kyu Suh and Ji-Kan Ryu

    Citation: BMC Urology 2021 21:103

    Content type: Research article

    Published on:

  3. The presence of hypoxia is a poor prognostic factor in prostate cancer and the hypoxic tumor microenvironment promotes radioresistance. There is potential for drug radiotherapy combinations to improve the ther...

    Authors: Becky A. S. Bibby, Niluja Thiruthaneeswaran, Lingjian Yang, Ronnie R. Pereira, Elisabet More, Darragh G. McArt, Paul O’Reilly, Robert G. Bristow, Kaye J. Williams, Ananya Choudhury and Catharine M. L. West

    Citation: BMC Urology 2021 21:96

    Content type: Research article

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  4. Long-term use of urethral catheters is associated with high risk of urinary tract infection (UTI) and blockage. Microbial biofilms are a common cause of catheter blockage, reducing their lifetime and significa...

    Authors: Florian H. H. Brill, Julia Hambach, Christian Utpatel, Diana C. Mogrovejo, Henrik Gabriel, Jan-Hendrik Klock, Joerg Steinmann and Andreas Arndt

    Citation: BMC Urology 2021 21:58

    Content type: Research article

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  5. The aim of this study was to compare the performance of the new flow cytometer UF-5000 with the UF-1000i and Gram staining for determining bacterial patterns in urine samples.

    Authors: Stephen Shei-Dei Yang, Chun-Chun Yang, Yi-Sheng Chen and Shang-Jen Chang

    Citation: BMC Urology 2021 21:24

    Content type: Research article

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  6. Bladder cancer (BC) is the 10th most common cancer in the UK, with about 10,000 new cases annually. About 75–85% of BC are non-muscle invasive (NMIBC), which is associated with high recurrence and progression ...

    Authors: Peter Ella-Tongwiis, Rebecca May Lamb, Alexander Makanga, Iqbal Shergill and Stephen Fôn Hughes

    Citation: BMC Urology 2020 20:187

    Content type: Research article

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  7. Interstitial cystitis/bladder pain syndrome is a bladder disease usually characterized by pain, urgency, and frequency. Interstitial cystitis is currently classified into two subtypes, with and without Hunner’...

    Authors: Elijah P. Ward, Sarah N. Bartolone, Michael B. Chancellor, Kenneth M. Peters and Laura E. Lamb

    Citation: BMC Urology 2020 20:180

    Content type: Research article

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  8. Bladder cancer (BC) is one of the most common malignancies of the urinary tract. The role of transient receptor potential melastatin 7 (TRPM7) in BC remains unclear. The aim of this study was to investigate th...

    Authors: Eun Hye Lee, So Young Chun, Bomi Kim, Bo Hyun Yoon, Jun Nyung Lee, Bum Soo Kim, Eun Sang Yoo, Sangkyu Lee, Phil Hyun Song, Tae Gyun Kwon and Yun-Sok Ha

    Citation: BMC Urology 2020 20:145

    Content type: Research article

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  9. To investigate the functions of the hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells in a rat model of overactive bladder syndrome.

    Authors: Chao Tan, Fei Yan, Li-Ping Yao, Jun-Ling Xing, Wei-Jun Qin, Kun Zhang, Guo-Jun Wu, Jian-Lin Yuan and Fei Liu

    Citation: BMC Urology 2020 20:140

    Content type: Research article

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  10. Calcium oxalate monohydrate (COM), the major crystalline composition of most kidney stones, induces inflammatory infiltration and injures in renal tubular cells. However, the mechanism of COM-induced toxic eff...

    Authors: Zhu Wang, Ming-xing Li, Chang-zhi Xu, Ying Zhang, Qiong Deng, Rui Sun, Qi-yi Hu, Sheng-ping Zhang, Jian-wen Zhang and Hui Liang

    Citation: BMC Urology 2020 20:136

    Content type: Research article

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  11. The main purpose of this study is to investigate the effect of silodosin on the urodynamic consequences in a previously established model of lower urinary tract symptoms associated with benign prostate hyperpl...

    Authors: Rana Assaly, Julie Faugeroux, Miguel Laurin, Sandrine Compagnie, Laurent Alexandre, François Giuliano and Delphine Behr-Roussel

    Citation: BMC Urology 2020 20:132

    Content type: Research article

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  12. The number of patients diagnosed and subsequently treated for kidney stones is increasing, and as such the number of post-operative complications is likely to increase. At present, little is known about the ro...

    Authors: Stephen Fôn Hughes, Alyson Jayne Moyes, Rebecca May Lamb, Peter Ella-tongwiis, Christopher Bell, Ahmed Moussa and Iqbal Shergill

    Citation: BMC Urology 2020 20:122

    Content type: Research article

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  14. Urinary tract infections (UTIs) are usually related to the presence of Escherichia coli, a microorganism that adopts an intracellular life-style during the pathogenesis of cystitis. Evidence of the underlying mec...

    Authors: Carlos Martínez-Figueroa, Karen Cortés-Sarabia, Luz del Carmen Alarcón-Romero, Hilda Guadalupe Catalán-Nájera, Micaela Martínez-Alarcón and Amalia Vences-Velázquez

    Citation: BMC Urology 2020 20:89

    Content type: Case report

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  16. Inflammation is often associated with several bladder dysfunctions, including overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such, inflammation of the bladder and the act...

    Authors: Zane Stromberga, Russ Chess-Williams and Christian Moro

    Citation: BMC Urology 2020 20:48

    Content type: Research article

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  17. Relaxin is an endogenous protein that has been shown to have antifibrotic properties in various organ systems. There has been no characterization of relaxin’s role in the human bladder. Our objective was to ch...

    Authors: Edward C. Diaz, Mason Briggs, Yan Wen, Guobing Zhuang, Shannon L. Wallace, Amy D. Dobberfuhl, Chia-Sui Kao and Bertha C. Chen

    Citation: BMC Urology 2020 20:44

    Content type: Research article

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  18. FTO is known to be associated with body mass and obesity in humans and its over-expression affects the energy metabolism of cancer cells. The aim of the present study is to investigate the biological role of F...

    Authors: Lijie Wen, Xianwei Pan, Yang Yu and Bo Yang

    Citation: BMC Urology 2020 20:39

    Content type: Research article

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  19. RNA sequencing data is providing abundant information about the levels of dysregulation of genes in various tumors. These data, as well as data based on older microarray technologies have enabled the identific...

    Authors: Sinisa Simonovic, Christian Hinze, Kai M. Schmidt-Ott, Jonas Busch, Monika Jung, Klaus Jung and Anja Rabien

    Citation: BMC Urology 2020 20:7

    Content type: Research article

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  20. The aim of the present study was to establish an animal model of Yang-Monti ileal ureter-bladder anastomosis and Yang-Monti ileal ureter-ureteral anastomosis and compare the advantages and disadvantages of the...

    Authors: Wang Zhenxing, Sun Zhaolin, Yang Xiushu, Luo Guangheng, Tian Ye, Shen Lei, Su Zhiyong and Liu Hongming

    Citation: BMC Urology 2019 19:129

    Content type: Research article

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  21. Activation of mast cells plays an important role in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC). Histamine, a mast cell-derived mediators, induced inflammation and hypersensitivity...

    Authors: Hui Shan, Er-Wei Zhang, Peng Zhang, Xiao-Dong Zhang, Ning Zhang, Peng Du and Yong Yang

    Citation: BMC Urology 2019 19:115

    Content type: Research article

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  22. Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor...

    Authors: Mikio Sugimoto, Xia Zhang, Nobufumi Ueda, Hiroyuki Tsunemori, Rikiya Taoka, Yusi Hayashida, Hiromi Hirama, Yasuyuki Miyauchi, Yuki Matsuoka, Hirohito Naito, Yu Osaki and Yosiyuki Kekehi

    Citation: BMC Urology 2019 19:99

    Content type: Research article

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BMC Urology

ISSN: 1471-2490

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