Pre-clinical and basic research

Section edited by Prof. Kenneth Iczkowski

This section considers articles describing all aspects of pre-clinical and basic research in the field of urology. This section covers a wide range of methodologies and study designs, including the identification of the molecular underpinnings of urological disease, and the application of this knowledge to clinical practice. Submissions describing clinical research should be directed to the sub-discipline specific sections.

Limited utility of qPCR-based detection of tumor-specific circulating mRNAs in whole blood from clear cell renal cell carcinoma patients

RNA sequencing data is providing abundant information about the levels of dysregulation of genes in various tumors. These data, as well as data based on older microarray technologies have enabled the identific...

Authors: Sinisa Simonovic, Christian Hinze, Kai M. Schmidt-Ott, Jonas Busch, Monika Jung, Klaus Jung and Anja Rabien

Citation: BMC Urology 2020 20:7

Content type: Research article

Published on: 4 February 2020
- View Full Text
- View PDF
Comparison of Yang-Monti ileal ureter-bladder anastomosis versus Yang-Monti ileal ureter-ureteral anastomosis for the treatment of ureteral stenosis: a randomized controlled trial in a miniature pig model

The aim of the present study was to establish an animal model of Yang-Monti ileal ureter-bladder anastomosis and Yang-Monti ileal ureter-ureteral anastomosis and compare the advantages and disadvantages of the...

Authors: Wang Zhenxing, Sun Zhaolin, Yang Xiushu, Luo Guangheng, Tian Ye, Shen Lei, Su Zhiyong and Liu Hongming

Citation: BMC Urology 2019 19:129

Content type: Research article

Published on: 10 December 2019
- View Full Text
- View PDF
Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis – significance in the responsiveness to antihistamine treatment and disease symptoms

Activation of mast cells plays an important role in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC). Histamine, a mast cell-derived mediators, induced inflammation and hypersensitivity...

Authors: Hui Shan, Er-Wei Zhang, Peng Zhang, Xiao-Dong Zhang, Ning Zhang, Peng Du and Yong Yang

Citation: BMC Urology 2019 19:115

Content type: Research article

Published on: 12 November 2019
- View Full Text
- View PDF
A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis

Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor...

Authors: Mikio Sugimoto, Xia Zhang, Nobufumi Ueda, Hiroyuki Tsunemori, Rikiya Taoka, Yusi Hayashida, Hiromi Hirama, Yasuyuki Miyauchi, Yuki Matsuoka, Hirohito Naito, Yu Osaki and Yosiyuki Kekehi

Citation: BMC Urology 2019 19:99

Content type: Research article

Published on: 23 October 2019
- View Full Text
- View PDF

Pre-clinical and basic research

Limited utility of qPCR-based detection of tumor-specific circulating mRNAs in whole blood from clear cell renal cell carcinoma patients

Comparison of Yang-Monti ileal ureter-bladder anastomosis versus Yang-Monti ileal ureter-ureteral anastomosis for the treatment of ureteral stenosis: a randomized controlled trial in a miniature pig model

Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis – significance in the responsiveness to antihistamine treatment and disease symptoms

A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis

BMC Urology

Contact us