Skip to main content

Pre-clinical and basic research

Section edited by Prof. Kenneth Iczkowski 

This section considers articles describing all aspects of pre-clinical and basic research in the field of urology. This section covers a wide range of methodologies and study designs, including the identification of the molecular underpinnings of urological disease, and the application of this knowledge to clinical practice. Submissions describing clinical research should be directed to the sub-discipline specific sections.

  1. The number of patients diagnosed and subsequently treated for kidney stones is increasing, and as such the number of post-operative complications is likely to increase. At present, little is known about the ro...

    Authors: Stephen Fôn Hughes, Alyson Jayne Moyes, Rebecca May Lamb, Peter Ella-tongwiis, Christopher Bell, Ahmed Moussa and Iqbal Shergill

    Citation: BMC Urology 2020 20:122

    Content type: Research article

    Published on:

  2. Urinary tract infections (UTIs) are usually related to the presence of Escherichia coli, a microorganism that adopts an intracellular life-style during the pathogenesis of cystitis. Evidence of the underlying mec...

    Authors: Carlos Martínez-Figueroa, Karen Cortés-Sarabia, Luz del Carmen Alarcón-Romero, Hilda Guadalupe Catalán-Nájera, Micaela Martínez-Alarcón and Amalia Vences-Velázquez

    Citation: BMC Urology 2020 20:89

    Content type: Case report

    Published on:

  3. Inflammation is often associated with several bladder dysfunctions, including overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such, inflammation of the bladder and the act...

    Authors: Zane Stromberga, Russ Chess-Williams and Christian Moro

    Citation: BMC Urology 2020 20:48

    Content type: Research article

    Published on:

  4. Relaxin is an endogenous protein that has been shown to have antifibrotic properties in various organ systems. There has been no characterization of relaxin’s role in the human bladder. Our objective was to ch...

    Authors: Edward C. Diaz, Mason Briggs, Yan Wen, Guobing Zhuang, Shannon L. Wallace, Amy D. Dobberfuhl, Chia-Sui Kao and Bertha C. Chen

    Citation: BMC Urology 2020 20:44

    Content type: Research article

    Published on:

  5. FTO is known to be associated with body mass and obesity in humans and its over-expression affects the energy metabolism of cancer cells. The aim of the present study is to investigate the biological role of F...

    Authors: Lijie Wen, Xianwei Pan, Yang Yu and Bo Yang

    Citation: BMC Urology 2020 20:39

    Content type: Research article

    Published on:

  6. RNA sequencing data is providing abundant information about the levels of dysregulation of genes in various tumors. These data, as well as data based on older microarray technologies have enabled the identific...

    Authors: Sinisa Simonovic, Christian Hinze, Kai M. Schmidt-Ott, Jonas Busch, Monika Jung, Klaus Jung and Anja Rabien

    Citation: BMC Urology 2020 20:7

    Content type: Research article

    Published on:

  7. The aim of the present study was to establish an animal model of Yang-Monti ileal ureter-bladder anastomosis and Yang-Monti ileal ureter-ureteral anastomosis and compare the advantages and disadvantages of the...

    Authors: Wang Zhenxing, Sun Zhaolin, Yang Xiushu, Luo Guangheng, Tian Ye, Shen Lei, Su Zhiyong and Liu Hongming

    Citation: BMC Urology 2019 19:129

    Content type: Research article

    Published on:

  8. Activation of mast cells plays an important role in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC). Histamine, a mast cell-derived mediators, induced inflammation and hypersensitivity...

    Authors: Hui Shan, Er-Wei Zhang, Peng Zhang, Xiao-Dong Zhang, Ning Zhang, Peng Du and Yong Yang

    Citation: BMC Urology 2019 19:115

    Content type: Research article

    Published on:

  9. Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor...

    Authors: Mikio Sugimoto, Xia Zhang, Nobufumi Ueda, Hiroyuki Tsunemori, Rikiya Taoka, Yusi Hayashida, Hiromi Hirama, Yasuyuki Miyauchi, Yuki Matsuoka, Hirohito Naito, Yu Osaki and Yosiyuki Kekehi

    Citation: BMC Urology 2019 19:99

    Content type: Research article

    Published on: