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Urological oncology

This section considers clinical studies relevant to oncological disorders in urology

Page 1 of 5

  1. Content type: Research article

    There is an increased incidence of renal cell carcinoma (RCC) in patients with metabolic syndrome who usually have high levels of serum triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C). P...

    Authors: Emre Karabay, Nejdet Karsiyakali, Serdar Duvar, Cagatay Tosun, Ahmet Ruknettin Aslan and Omer Ergin Yucebas

    Citation: BMC Urology 2019 19:85

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  2. Content type: Research article

    In patients presenting with limited nodal recurrence following radical prostatectomy (RP), stereotactic body radiotherapy (SBRT) results might improve with a better case selection.

    Authors: Christoph Oehler, Michel Zimmermann, Lukas Adam, Juergen Curschmann, Marcin Sumila, Räto T. Strebel, Richard Cathomas, Qiyu Li, Uwe Schneider and Daniel R. Zwahlen

    Citation: BMC Urology 2019 19:84

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  3. Content type: Research article

    Perivesical lymph nodes (PVLNs) are occasionally isolated during grossing of cystectomy specimens. However, the prognostic implications of the involvement of PVLNs in bladder cancer patients, especially those ...

    Authors: Meenal Sharma, Takuro Goto, Zhiming Yang and Hiroshi Miyamoto

    Citation: BMC Urology 2019 19:77

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  4. Content type: Research article

    Strong evidence comparing effectiveness between nephron-sparing intervention (NSI) and active surveillance (AS) is lacking. Thus, we aim to compare the outcomes of survival, including cancer-specific survival ...

    Authors: Run-Qi Guo and Xiao-Guang Li

    Citation: BMC Urology 2019 19:74

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  5. Content type: Research article

    Patient-related factors such as concern about cancer are believed to influence both men’s decisions to undergo prostate specific antigen (PSA) testing and to have definitive treatment if diagnosed with low ris...

    Authors: Kerri Beckmann, Netty Kinsella, Henrik Olsson, Anna Wallerstedt Lantz, Tobias Nordstrom, Markus Aly, Jan Adolfsson, Martin Eklund and Mieke Van Hemelrijck

    Citation: BMC Urology 2019 19:73

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  6. Content type: Research article

    Due to the usage of various measurement methods and definitions, comparing continence rates after radical prostatectomy is a challenging task. This study compares continence rates based on different methods an...

    Authors: Sigrun Holze, Meinhard Mende, Karl V. Healy, Norbert Koehler, Lutz Gansera, Michael C. Truss, Udo Rebmann, Stephan Degener and Jens-Uwe Stolzenburg

    Citation: BMC Urology 2019 19:70

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  7. Content type: Research article

    The expression level of ribonucleotide reductase subunit M1 (RRM1) is closely related to the effect of gemcitabine-based therapy in advanced bladder cancer. However, the value of RRM1 expression in predicting ...

    Authors: Zhenxing Yang, Bingqiang Fu, Luqiang Zhou, Jie Xu, Ping Hao and Zhenqiang Fang

    Citation: BMC Urology 2019 19:69

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  8. Content type: Research article

    Epithelial cell adhesion molecule (EpCAM) expression has been reported in many types of cancer, including prostate cancer (PCa). However, the role of EpCAM expression remains inconsistent. We conducted a meta-...

    Authors: Yu Hu, Qiong Wu, Jialin Gao, Yongrui Zhang and Yuantao Wang

    Citation: BMC Urology 2019 19:67

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  9. Content type: Research article

    To evaluate the efficacy of pelvic plexus block (PPB) in relief pain during transperineal template-guided prostate biopsy (TTPB), compared with conventional periprostatic nerve block (PNB).

    Authors: Xue-fei Ding, Tian-bao Huang, Sheng-ming Lu, Hua-zhi Tao, Xiao-fang Ye, Fei Wang, Yao-zong Xu, Jia-nan Xu, Yu-quan Zhou and Yang Luan

    Citation: BMC Urology 2019 19:63

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  10. Content type: Research article

    Despite the fact that testicular cancer presents good prognosis, wide variations in mortality rates have been reported internationally. In Brazil, mortality trends and estimates have not been fully assessed. T...

    Authors: Samara Carollyne Mafra Soares, Katarina Márcia Rodrigues dos Santos, Fabia Cheyenne Gomes de Morais Fernandes, Isabelle Ribeiro Barbosa and Dyego Leandro Bezerra de Souza

    Citation: BMC Urology 2019 19:59

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  11. Content type: Technical advance

    There is a change in the position of the remaining anatomical structures of the lower urinary tract system following radical prostatectomy. The aims of this investigation were to describe three novel methods u...

    Authors: Hong Koo Ha, Henk B. Luiting, Petra L. Graham, Manish I. Patel, Jaspreet S. Sandhu, Oguz Akin and Sean F. Mungovan

    Citation: BMC Urology 2019 19:54

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  12. Content type: Research article

    Let-7 is one of the earliest discovered microRNAs(miRNAs) and has been reported to be down-regulated in multiple malignant tumors. The effects and molecular mechanisms of let-7i in bladder cancer are still unc...

    Authors: M-M Qin, X. Chai, H-B Huang, G. Feng, X-N Li, J. Zhang, R. Zheng, X-C Liu and C. Pu

    Citation: BMC Urology 2019 19:53

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  13. Content type: Research article

    Testicular epidermoid cysts (TECs) are rare benign testicular neoplasms. As TECs are rarely associated with germ cell tumours (GCTs), the understanding of biological behaviour and clinical management of TEC is...

    Authors: Petra Anheuser, J. Kranz, E. Stolle, D. Höflmayer, F. Büscheck, S. Mühlstädt, G. Lock and K. P. Dieckmann

    Citation: BMC Urology 2019 19:52

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  14. Content type: Research article

    Physicians doubt percutaneous nephrostomy (PCN) insertion on cancer related hydronephrosis patients causes tumor seeding and worse cancer control. In this article, we attempted to determine if preoperative PCN...

    Authors: Guan-Lin Huang, Hao-Lun Luo and Po-Hui Chiang

    Citation: BMC Urology 2019 19:50

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  15. Content type: Research article

    Conflicting evidence exists regarding the effect of hypertension on the prognosis of metastatic renal cell carcinoma (mRCC) patients treated with tyrosine kinase inhibitors (TKIs). This study aimed to assess t...

    Authors: Yu Liu, Liang Zhou, Yuntian Chen, Banghua Liao, Donghui Ye, Kunjie Wang and Hong Li

    Citation: BMC Urology 2019 19:49

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  16. Content type: Research article

    The efficacy of partial nephrectomy (PN) for T1b renal cell carcinoma (RCC) is controversial. The oncological outcomes, the change in postoperative renal function and the perioperative complications are unclear.

    Authors: Yu-Li Jiang, Cheng-Xia Peng, Heng-Zi Wang and Lu-Jie Qian

    Citation: BMC Urology 2019 19:48

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  17. Content type: Research article

    The identification of appropriate biomarkers is essential to support important clinical decisions in patients with prostate cancer. The aim of our study was a systematic bioinformatical analysis of the mRNA ex...

    Authors: Anika Kremer, Tobias Kremer, Glen Kristiansen and Yuri Tolkach

    Citation: BMC Urology 2019 19:46

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  18. Content type: Research article

    Prostate cancer is the most commonly diagnosed cancer in men. Radiotherapy represents one major treatment option in different therapeutic settings. As patients increasingly rely on internet-based medical infor...

    Authors: S. Janssen, F. B. Fahlbusch, L. Käsmann, D. Rades and D. Vordermark

    Citation: BMC Urology 2019 19:42

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  19. Content type: Research article

    Intrafascial prostatectomy was a modified technique from the conventional nerve-sparing surgery in order to improve patients’ post-surgical continence and erectile function; however, ongoing controversy exists...

    Authors: Xiao Wang, Yiqi Wu, Jia Guo, Hui Chen, Xiaodong Weng and Xiuheng Liu

    Citation: BMC Urology 2019 19:41

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  20. Content type: Research article

    To assess the prognostic value of the extent of positive surgical margins (PSM) following radical prostatectomy (RP) on biochemical recurrence (BR) with long-term follow-up.

    Authors: Yoann Koskas, François Lannes, Nicolas Branger, Sophie Giusiano, Nicolas Guibert, Géraldine Pignot, Jochen Walz, Dominique Rossi and Cyrille Bastide

    Citation: BMC Urology 2019 19:37

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  21. Content type: Research article

    In this era of precision medicine, the DNA damage response (DDR) pathway has been shown to be a viable target of intervention in metastatic castration-resistant prostate cancer (CRPC) as approximately one-thir...

    Authors: Isaac E. Kim Jr, Sinae Kim, Arnav Srivastava, Biren Saraiya, Tina Mayer, Wun-Jae Kim and Isaac Yi Kim

    Citation: BMC Urology 2019 19:33

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  22. Content type: Research article

    Results from randomized phase III trials have shown that thrice-weekly docetaxel added to androgen-deprivation therapy (ADT) has a significant impact on the survival of patients with metastatic castration-naïv...

    Authors: Sang Eun Yoon, Youjin Kim, Jangho Cho, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byoung Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Su Jin Lee and Se Hoon Park

    Citation: BMC Urology 2019 19:30

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  23. Content type: Research article

    There is no criterion for determining whether female patients operated with cystectomy would benefit from hysterectomy. This study compares the oncological outcomes between female patients receiving uterus pre...

    Authors: Haiwen Huang, Bing Yan, Meixia Shang, Libo Liu, Han Hao and Zhijun Xi

    Citation: BMC Urology 2019 19:28

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  24. Content type: Research article

    To investigate the prognostic risk factors and postoperative recurrence of bladder cancer in patients with upper urinary tract urothelial carcinomas (UTUCs).

    Authors: Qingwei Wang, Tao Zhang, Junwei Wu, Jianguo Wen, Deshang Tao, Tingxiang Wan and Wen Zhu

    Citation: BMC Urology 2019 19:24

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  25. Content type: Research article

    New biological prognostic predictors have been studied; however, some factors have limited clinical application due to tissue-specific expression and high cost. There is the need for a promising predictive fac...

    Authors: Yun-Sok Ha, Sang Won Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Won Tae Kim, Wun-Jae Kim and Tae-Hwan Kim

    Citation: BMC Urology 2019 19:10

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  26. Content type: Research article

    Patients with newly diagnosed non-metastatic prostate adenocarcinoma are typically classified as at low, intermediate, or high risk of disease progression using blood prostate-specific antigen concentration, t...

    Authors: Wendy L. Johnston, Charles N. Catton and Carol J. Swallow

    Citation: BMC Urology 2019 19:4

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  27. Content type: Research article

    Optimal treatment of high-risk prostate cancer remains controversial. We aimed to compare treatment outcomes of prostate cancer patients treated with definitive external-beam radiotherapy (ExRT) or radical pro...

    Authors: Fundagul Andic, Volkan Izol, Serkan Gokcay, Hasan Suat Arslantas, Yildirim Bayazit, Hatice Coskun, Mustafa Zuhtu Tansug and Yasar Sertdemir

    Citation: BMC Urology 2019 19:3

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  28. Content type: Research article

    Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin le...

    Authors: Yongquan Tang, Zhihong Liu, Jiayu Liang, Ruochen Zhang, Kan Wu, Zijun Zou, Chuan Zhou, Fuxun Zhang and Yiping Lu

    Citation: BMC Urology 2018 18:111

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  29. Content type: Research article

    To evaluate the efficacy and safety of abiraterone acetate (AA) plus prednisone compared with prednisone alone in Asian patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC),...

    Authors: Liancheng Fan, Baijun Dong, Chenfei Chi, Yanqing Wang, Yiming Gong, Jianjun Sha, Jiahua Pan, Xun Shangguan, Yiran Huang, Lixin Zhou and Wei Xue

    Citation: BMC Urology 2018 18:110

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  30. Content type: Research article

    Epidermal growth factor receptor (EGFR) overexpression is believed to be associated with bladder cancer (BC) progression and poor clinical outcomes. In vivo studies have linked EGFR subcellular trafficking and...

    Authors: Ahmed M. Mansour, Mona Abdelrahim, Mahmoud Laymon, Mamdouh Elsherbeeny, Mohammed Sultan, Ahmed Shokeir, Ahmed Mosbah, Hassan Abol-Enein, Amira Awadalla, Eunho Cho, Vikram Sairam, Taeeun D. Park, Muhammad Shahid and Jayoung Kim

    Citation: BMC Urology 2018 18:100

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  31. Content type: Research article

    Warm ischemia (WI) and bleeding constitute the main challenges for surgeons during laparoscopic partial nephrectomy (LPN). Current literature on the use of lasers for cutting and coagulation remains scarce and...

    Authors: Martin Drerup, Ahmed Magdy, Martina Hager, Daniela Colleselli, Thomas Kunit, Lukas Lusuardi, Günter Janetschek and Michael Mitterberger

    Citation: BMC Urology 2018 18:99

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  32. Content type: Research article

    Bladder cancers have been characterized as a tumor group in which the immunological response is relatively well preserved. Programmed death ligand 1 (PD-L1, B7-H1, CD274) has been shown to be expressed in seve...

    Authors: Takashi Kawahara, Yukari Ishiguro, Shinji Ohtake, Ikuma Kato, Yusuke Ito, Hiroki Ito, Kazuhide Makiyama, Keiichi Kondo, Yasuhide Miyoshi, Yasushi Yumura, Narihiko Hayashi, Hisashi Hasumi, Kimito Osaka, Kentaro Muraoka, Koji Izumi, Jun-ichi Teranishi…

    Citation: BMC Urology 2018 18:97

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  33. Content type: Research article

    Primary retroperitoneal lymph node dissection (RPLND) ultimately lost its role as the standard management of clinical stage (CS) 1 nonseminomatous (NS) testicular germ cell tumours (GCTs) in Europe when the Eu...

    Authors: K.-P. Dieckmann, P. Anheuser, M. Kulejewski, R. Gehrckens and B. Feyerabend

    Citation: BMC Urology 2018 18:95

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  34. Content type: Research article

    Intravesical Mitomycin-C (MMC) following transurethral resection of bladder tumor (TURBT), while efficacious, is associated with side effects and poor utilization. Continuous saline bladder irrigation (CSBI) h...

    Authors: Andrew T. Lenis, Kian Asanad, Maher Blaibel, Nicholas M. Donin and Karim Chamie

    Citation: BMC Urology 2018 18:93

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  35. Content type: Research article

    Radical cystectomy bears a considerable perioperative mortality risk particularly in elderly patients. In this study, we searched for predictors of perioperative and long-term competing (non-bladder cancer) mo...

    Authors: Michael Froehner, Rainer Koch, Matthias Hübler, Ulrike Heberling, Vladimir Novotny, Stefan Zastrow, Oliver W. Hakenberg and Manfred P. Wirth

    Citation: BMC Urology 2018 18:91

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  36. Content type: Research article

    This study aims to prospectively evaluate the ability of Neutrophil-to-Lymphocyte ratio (NLR) to forecast recurrence in patients with non-muscle invasive bladder cancer (NMIBC). This is a continuation of our t...

    Authors: Itamar Getzler, Zaher Bahouth, Ofer Nativ, Jacob Rubinstein and Sarel Halachmi

    Citation: BMC Urology 2018 18:90

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  37. Content type: Study protocol

    The goal of radical prostatectomy is to achieve the optimal balance between complete cancer removal and preserving a patient’s urinary and sexual function. Performing a wider excision of peri-prostatic tissue ...

    Authors: R. H. Breau, R. M. Kumar, L. T. Lavallee, I. Cagiannos, C. Morash, M. Horrigan, S. Cnossen, R. Mallick, D. Stacey, M. Fung-Kee-Fung, R. Morash, J. Smylie, K. Witiuk and D. A. Fergusson

    Citation: BMC Urology 2018 18:89

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  38. Content type: Research article

    The tumor draining lymph node concept was first described in penile cancer for staging. Immunohistochemistry and histopathology evaluations are routinely used in clinical practice to examine lymph nodes for me...

    Authors: Lu Zhang, Jin Hu, A. Ali Zirakzadeh, Jesper Rosvall, Mats Hedlund, Ping Sheng Hu, Robert P.A. Wallin, Amir Sherif and Ola Winqvist

    Citation: BMC Urology 2018 18:86

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  39. Content type: Research article

    Immediate early response gene 3 (IER3) is a stress-inducible gene, which exerts diverse effects in regulating cell apoptosis and cell cycle. Growing evidence shows that IER3 functions either as an oncogene or ...

    Authors: Jianheng Ye, Yanqiong Zhang, Zhiduan Cai, Minyao Jiang, Bowei Li, Guo Chen, Yanru Zeng, Yuxiang Liang, Shulin Wu, Zongwei Wang, Huichan He, Weide Zhong and Chin-Lee Wu

    Citation: BMC Urology 2018 18:82

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  40. Content type: Review

    Most patients with advanced prostate cancer develop bone metastases, which often result in painful and debilitating skeletal-related events. Inhibitors of bone resorption, such as bisphosphonates and denosumab...

    Authors: Jean-Jacques Body, Roger von Moos, Daniela Niepel and Bertrand Tombal

    Citation: BMC Urology 2018 18:81

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  41. Content type: Research article

    BRAF-activated long non-coding RNA (BANCR) has been associated with various types of cancer. Nevertheless, the role of BANCR in clear cell renal cell carcinoma (ccRCC) is still not fully understood. This study...

    Authors: Sheng Xue, Sheng-Qun Jiang, Qing-wen Li, Sheng Wang, Jian Li, Shuai Yang, Hai-Min Zhang, Yun-Fei Xu, Long-Sheng Wang and Jun-Hua Zheng

    Citation: BMC Urology 2018 18:79

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  42. Content type: Research article

    Refinement of parameters defining prostate cancer (PC) prognosis are urgently needed to identify patients with indolent versus aggressive disease. The Canadian Prostate Cancer Biomaker Network (CPCBN) consists...

    Authors: Véronique Ouellet, Armen Aprikian, Alain Bergeron, Fadi Brimo, Robert G. Bristow, Simone Chevalier, Darrel Drachenberg, Ladan Fazli, Neil E. Fleshner, Martin Gleave, Pierre Karakiewicz, Laurence Klotz, Louis Lacombe, Jean-Baptiste Lattouf, Theodorus van der Kwast, Jeremy A. Squire…

    Citation: BMC Urology 2018 18:78

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  43. Content type: Research article

    This analysis estimated the number needed to treat with enzalutamide versus bicalutamide to achieve one additional patient with chemotherapy-naïve metastatic castration-resistant prostate cancer who would obta...

    Authors: Neil M. Schultz, Neal D. Shore, Simon Chowdhury, Laurence H. Klotz, Raoul S. Concepcion, David F. Penson, Lawrence I. Karsh, Hongbo Yang, Bruce A. Brown, Arie Barlev and Scott C. Flanders

    Citation: BMC Urology 2018 18:77

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    The Correction to this article has been published in BMC Urology 2018 18:84

  44. Content type: Research article

    To study the expression pattern, localisation and potential clinical significance of aquaporin water channels (AQP) both in prostate cancer (PC) cell lines and in benign and malignant human prostate tissue.

    Authors: Johannes Bründl, Sabine Wallinger, Johannes Breyer, Florian Weber, Matthias Evert, Nikolaos Theodoros Georgopoulos, Bernd Rosenhammer, Maximilian Burger, Wolfgang Otto and Peter Rubenwolf

    Citation: BMC Urology 2018 18:75

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  45. Content type: Research article

    To explore the feasibility and long-term outcomes of renal preservation in a retrospective cohort of patients with ureteral urothelial carcinoma undergoing total ureterectomy with ileal-ureteral substitution.

    Authors: Yin-Chien Ou, Che-Yuan Hu, Hong-Lin Cheng and Wen-Horng Yang

    Citation: BMC Urology 2018 18:73

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  46. Content type: Research article

    The benefits of PSA-based screening for prostate cancer (PCa) are controversial. The Canadian and American Task Forces on Preventive Health Care (CTFPHC & USPSTF) have released recommendations against the use ...

    Authors: Ahmed S. Zakaria, Alice Dragomir, Fadi Brimo, Wassim Kassouf, Simon Tanguay and Armen Aprikian

    Citation: BMC Urology 2018 18:69

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