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Urological oncology

This section considers clinical studies relevant to oncological disorders in urology

Page 1 of 5

  1. Content type: Research article

    To assess the prognostic value of the extent of positive surgical margins (PSM) following radical prostatectomy (RP) on biochemical recurrence (BR) with long-term follow-up.

    Authors: Yoann Koskas, François Lannes, Nicolas Branger, Sophie Giusiano, Nicolas Guibert, Géraldine Pignot, Jochen Walz, Dominique Rossi and Cyrille Bastide

    Citation: BMC Urology 2019 19:37

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  2. Content type: Research article

    In this era of precision medicine, the DNA damage response (DDR) pathway has been shown to be a viable target of intervention in metastatic castration-resistant prostate cancer (CRPC) as approximately one-thir...

    Authors: Isaac E. Kim Jr, Sinae Kim, Arnav Srivastava, Biren Saraiya, Tina Mayer, Wun-Jae Kim and Isaac Yi Kim

    Citation: BMC Urology 2019 19:33

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  3. Content type: Research article

    Results from randomized phase III trials have shown that thrice-weekly docetaxel added to androgen-deprivation therapy (ADT) has a significant impact on the survival of patients with metastatic castration-naïv...

    Authors: Sang Eun Yoon, Youjin Kim, Jangho Cho, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byoung Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Su Jin Lee and Se Hoon Park

    Citation: BMC Urology 2019 19:30

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  4. Content type: Research article

    There is no criterion for determining whether female patients operated with cystectomy would benefit from hysterectomy. This study compares the oncological outcomes between female patients receiving uterus pre...

    Authors: Haiwen Huang, Bing Yan, Meixia Shang, Libo Liu, Han Hao and Zhijun Xi

    Citation: BMC Urology 2019 19:28

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  5. Content type: Research article

    To investigate the prognostic risk factors and postoperative recurrence of bladder cancer in patients with upper urinary tract urothelial carcinomas (UTUCs).

    Authors: Qingwei Wang, Tao Zhang, Junwei Wu, Jianguo Wen, Deshang Tao, Tingxiang Wan and Wen Zhu

    Citation: BMC Urology 2019 19:24

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  6. Content type: Research article

    New biological prognostic predictors have been studied; however, some factors have limited clinical application due to tissue-specific expression and high cost. There is the need for a promising predictive fac...

    Authors: Yun-Sok Ha, Sang Won Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Won Tae Kim, Wun-Jae Kim and Tae-Hwan Kim

    Citation: BMC Urology 2019 19:10

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  7. Content type: Research article

    Patients with newly diagnosed non-metastatic prostate adenocarcinoma are typically classified as at low, intermediate, or high risk of disease progression using blood prostate-specific antigen concentration, t...

    Authors: Wendy L. Johnston, Charles N. Catton and Carol J. Swallow

    Citation: BMC Urology 2019 19:4

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  8. Content type: Research article

    Optimal treatment of high-risk prostate cancer remains controversial. We aimed to compare treatment outcomes of prostate cancer patients treated with definitive external-beam radiotherapy (ExRT) or radical pro...

    Authors: Fundagul Andic, Volkan Izol, Serkan Gokcay, Hasan Suat Arslantas, Yildirim Bayazit, Hatice Coskun, Mustafa Zuhtu Tansug and Yasar Sertdemir

    Citation: BMC Urology 2019 19:3

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  9. Content type: Research article

    Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin le...

    Authors: Yongquan Tang, Zhihong Liu, Jiayu Liang, Ruochen Zhang, Kan Wu, Zijun Zou, Chuan Zhou, Fuxun Zhang and Yiping Lu

    Citation: BMC Urology 2018 18:111

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  10. Content type: Research article

    To evaluate the efficacy and safety of abiraterone acetate (AA) plus prednisone compared with prednisone alone in Asian patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC),...

    Authors: Liancheng Fan, Baijun Dong, Chenfei Chi, Yanqing Wang, Yiming Gong, Jianjun Sha, Jiahua Pan, Xun Shangguan, Yiran Huang, Lixin Zhou and Wei Xue

    Citation: BMC Urology 2018 18:110

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  11. Content type: Research article

    Epidermal growth factor receptor (EGFR) overexpression is believed to be associated with bladder cancer (BC) progression and poor clinical outcomes. In vivo studies have linked EGFR subcellular trafficking and...

    Authors: Ahmed M. Mansour, Mona Abdelrahim, Mahmoud Laymon, Mamdouh Elsherbeeny, Mohammed Sultan, Ahmed Shokeir, Ahmed Mosbah, Hassan Abol-Enein, Amira Awadalla, Eunho Cho, Vikram Sairam, Taeeun D. Park, Muhammad Shahid and Jayoung Kim

    Citation: BMC Urology 2018 18:100

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  12. Content type: Research article

    Warm ischemia (WI) and bleeding constitute the main challenges for surgeons during laparoscopic partial nephrectomy (LPN). Current literature on the use of lasers for cutting and coagulation remains scarce and...

    Authors: Martin Drerup, Ahmed Magdy, Martina Hager, Daniela Colleselli, Thomas Kunit, Lukas Lusuardi, Günter Janetschek and Michael Mitterberger

    Citation: BMC Urology 2018 18:99

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  13. Content type: Research article

    Bladder cancers have been characterized as a tumor group in which the immunological response is relatively well preserved. Programmed death ligand 1 (PD-L1, B7-H1, CD274) has been shown to be expressed in seve...

    Authors: Takashi Kawahara, Yukari Ishiguro, Shinji Ohtake, Ikuma Kato, Yusuke Ito, Hiroki Ito, Kazuhide Makiyama, Keiichi Kondo, Yasuhide Miyoshi, Yasushi Yumura, Narihiko Hayashi, Hisashi Hasumi, Kimito Osaka, Kentaro Muraoka, Koji Izumi, Jun-ichi Teranishi…

    Citation: BMC Urology 2018 18:97

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  14. Content type: Research article

    Primary retroperitoneal lymph node dissection (RPLND) ultimately lost its role as the standard management of clinical stage (CS) 1 nonseminomatous (NS) testicular germ cell tumours (GCTs) in Europe when the Eu...

    Authors: K.-P. Dieckmann, P. Anheuser, M. Kulejewski, R. Gehrckens and B. Feyerabend

    Citation: BMC Urology 2018 18:95

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  15. Content type: Research article

    Intravesical Mitomycin-C (MMC) following transurethral resection of bladder tumor (TURBT), while efficacious, is associated with side effects and poor utilization. Continuous saline bladder irrigation (CSBI) h...

    Authors: Andrew T. Lenis, Kian Asanad, Maher Blaibel, Nicholas M. Donin and Karim Chamie

    Citation: BMC Urology 2018 18:93

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  16. Content type: Research article

    Radical cystectomy bears a considerable perioperative mortality risk particularly in elderly patients. In this study, we searched for predictors of perioperative and long-term competing (non-bladder cancer) mo...

    Authors: Michael Froehner, Rainer Koch, Matthias Hübler, Ulrike Heberling, Vladimir Novotny, Stefan Zastrow, Oliver W. Hakenberg and Manfred P. Wirth

    Citation: BMC Urology 2018 18:91

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  17. Content type: Research article

    This study aims to prospectively evaluate the ability of Neutrophil-to-Lymphocyte ratio (NLR) to forecast recurrence in patients with non-muscle invasive bladder cancer (NMIBC). This is a continuation of our t...

    Authors: Itamar Getzler, Zaher Bahouth, Ofer Nativ, Jacob Rubinstein and Sarel Halachmi

    Citation: BMC Urology 2018 18:90

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  18. Content type: Study protocol

    The goal of radical prostatectomy is to achieve the optimal balance between complete cancer removal and preserving a patient’s urinary and sexual function. Performing a wider excision of peri-prostatic tissue ...

    Authors: R. H. Breau, R. M. Kumar, L. T. Lavallee, I. Cagiannos, C. Morash, M. Horrigan, S. Cnossen, R. Mallick, D. Stacey, M. Fung-Kee-Fung, R. Morash, J. Smylie, K. Witiuk and D. A. Fergusson

    Citation: BMC Urology 2018 18:89

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  19. Content type: Research article

    The tumor draining lymph node concept was first described in penile cancer for staging. Immunohistochemistry and histopathology evaluations are routinely used in clinical practice to examine lymph nodes for me...

    Authors: Lu Zhang, Jin Hu, A. Ali Zirakzadeh, Jesper Rosvall, Mats Hedlund, Ping Sheng Hu, Robert P.A. Wallin, Amir Sherif and Ola Winqvist

    Citation: BMC Urology 2018 18:86

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  20. Content type: Research article

    Immediate early response gene 3 (IER3) is a stress-inducible gene, which exerts diverse effects in regulating cell apoptosis and cell cycle. Growing evidence shows that IER3 functions either as an oncogene or ...

    Authors: Jianheng Ye, Yanqiong Zhang, Zhiduan Cai, Minyao Jiang, Bowei Li, Guo Chen, Yanru Zeng, Yuxiang Liang, Shulin Wu, Zongwei Wang, Huichan He, Weide Zhong and Chin-Lee Wu

    Citation: BMC Urology 2018 18:82

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  21. Content type: Review

    Most patients with advanced prostate cancer develop bone metastases, which often result in painful and debilitating skeletal-related events. Inhibitors of bone resorption, such as bisphosphonates and denosumab...

    Authors: Jean-Jacques Body, Roger von Moos, Daniela Niepel and Bertrand Tombal

    Citation: BMC Urology 2018 18:81

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  22. Content type: Research article

    BRAF-activated long non-coding RNA (BANCR) has been associated with various types of cancer. Nevertheless, the role of BANCR in clear cell renal cell carcinoma (ccRCC) is still not fully understood. This study...

    Authors: Sheng Xue, Sheng-Qun Jiang, Qing-wen Li, Sheng Wang, Jian Li, Shuai Yang, Hai-Min Zhang, Yun-Fei Xu, Long-Sheng Wang and Jun-Hua Zheng

    Citation: BMC Urology 2018 18:79

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  23. Content type: Research article

    Refinement of parameters defining prostate cancer (PC) prognosis are urgently needed to identify patients with indolent versus aggressive disease. The Canadian Prostate Cancer Biomaker Network (CPCBN) consists...

    Authors: Véronique Ouellet, Armen Aprikian, Alain Bergeron, Fadi Brimo, Robert G. Bristow, Simone Chevalier, Darrel Drachenberg, Ladan Fazli, Neil E. Fleshner, Martin Gleave, Pierre Karakiewicz, Laurence Klotz, Louis Lacombe, Jean-Baptiste Lattouf, Theodorus van der Kwast, Jeremy A. Squire…

    Citation: BMC Urology 2018 18:78

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  24. Content type: Research article

    This analysis estimated the number needed to treat with enzalutamide versus bicalutamide to achieve one additional patient with chemotherapy-naïve metastatic castration-resistant prostate cancer who would obta...

    Authors: Neil M. Schultz, Neal D. Shore, Simon Chowdhury, Laurence H. Klotz, Raoul S. Concepcion, David F. Penson, Lawrence I. Karsh, Hongbo Yang, Bruce A. Brown, Arie Barlev and Scott C. Flanders

    Citation: BMC Urology 2018 18:77

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    The Correction to this article has been published in BMC Urology 2018 18:84

  25. Content type: Research article

    To study the expression pattern, localisation and potential clinical significance of aquaporin water channels (AQP) both in prostate cancer (PC) cell lines and in benign and malignant human prostate tissue.

    Authors: Johannes Bründl, Sabine Wallinger, Johannes Breyer, Florian Weber, Matthias Evert, Nikolaos Theodoros Georgopoulos, Bernd Rosenhammer, Maximilian Burger, Wolfgang Otto and Peter Rubenwolf

    Citation: BMC Urology 2018 18:75

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  26. Content type: Research article

    To explore the feasibility and long-term outcomes of renal preservation in a retrospective cohort of patients with ureteral urothelial carcinoma undergoing total ureterectomy with ileal-ureteral substitution.

    Authors: Yin-Chien Ou, Che-Yuan Hu, Hong-Lin Cheng and Wen-Horng Yang

    Citation: BMC Urology 2018 18:73

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  27. Content type: Research article

    The benefits of PSA-based screening for prostate cancer (PCa) are controversial. The Canadian and American Task Forces on Preventive Health Care (CTFPHC & USPSTF) have released recommendations against the use ...

    Authors: Ahmed S. Zakaria, Alice Dragomir, Fadi Brimo, Wassim Kassouf, Simon Tanguay and Armen Aprikian

    Citation: BMC Urology 2018 18:69

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  28. Content type: Research article

    Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasiv...

    Authors: Young Saing Kim, Kyung Kim, Ghee-Young Kwon, Su Jin Lee and Se Hoon Park

    Citation: BMC Urology 2018 18:68

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  29. Content type: Research article

    The preoperative neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CRP/Alb ratio) and platelet-to-lymphocyte ratio (PLR) have been demonstrated to predict the clinical outcome of various ...

    Authors: Sezim Agizamhan, Feng Qu, Ning Liu, Jing Sun, Wei Xu, Lihua Zhang, Hongqian Guo and Weidong Gan

    Citation: BMC Urology 2018 18:60

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  30. Content type: Research article

    Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not ...

    Authors: Atif Ali hashmi, Zubaida Fida Hussain, Muhammad Irfan, Erum Yousuf Khan, Naveen Faridi, Hanna Naqvi, Amir Khan and Muhammad Muzzammil Edhi

    Citation: BMC Urology 2018 18:59

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  31. Content type: Research article

    This study was conducted to determine whether the location of the bladder neck in postoperative cystography predicts recovery of continence after radical prostatectomy.

    Authors: Susumu Kageyama, Tetsuya Yoshida, Masayuki Nagasawa, Shigehisa Kubota, Keiji Tomita, Kenichi Kobayashi, Ryosuke Murai, Teruhiko Tsuru, Eiki Hanada, Kazuyoshi Johnin, Mitsuhiro Narita and Akihiro Kawauchi

    Citation: BMC Urology 2018 18:52

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  32. Content type: Research article

    To determine whether prebiopsy multiparametric magnetic resonance imaging (mpMRI) with subsequent systematic plus targeted biopsies for suspicious lesions improve prostate cancer detection compared with standa...

    Authors: Satoshi Washino, Shigeru Kobayashi, Tomohisa Okochi, Tomohiro Kameda, Tsuzumi Konoshi, Tomoaki Miyagawa, Tatsuya Takayama and Tatsuo Morita

    Citation: BMC Urology 2018 18:51

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  33. Content type: Research article

    Hospital length of stay (LOS) has recently been receiving increasing attention as a marker of medical resource consumption. Identifying predictors of longer LOS can better equip doctors to counsel patients and...

    Authors: Qingmei Huang, Ping Jiang, Lina Feng, Liping Xie, Shuo Wang, Dan Xia, Baihua Shen, Baiye Jin, Li Zheng and Wei Wang

    Citation: BMC Urology 2018 18:43

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  34. Content type: Case report

    Primary synovial sarcoma of the kidney is a rare type of soft tissue sarcoma. Its presenting features can resemble those of other renal tumors; rendering its early diagnosis, a dilemma. Several cases of renal ...

    Authors: Alissar El Chediak, Deborah Mukherji, Sally Temraz, Samer Nassif, Sara Sinno, Rami Mahfouz and Ali Shamseddine

    Citation: BMC Urology 2018 18:40

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  35. Content type: Research article

    Less evidence is known about the role of early changes in serum biomarker after androgen deprivation therapy (ADT) in patients with metastatic hormone-sensitive prostate cancer (mHSPC). Here we evaluated the i...

    Authors: Hiromi Sato, Shintaro Narita, Norihiko Tsuchiya, Atsushi Koizumi, Taketoshi Nara, Sohei Kanda, Kazuyuki Numakura, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Shigeru Satoh, Kyoko Nomura and Tomonori Habuchi

    Citation: BMC Urology 2018 18:32

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  36. Content type: Research article

    Lymph node dissection (LND) is not routinely performed during radical nephroureterectomy (RNU) in upper tract urothelial carcinomas (UTUC) and the role of LND has been controversial. We aim to investigate whet...

    Authors: Runqi Guo, Yuze Zhu, Gengyan Xiong, Xuesong Li, Kai Zhang and Liqun Zhou

    Citation: BMC Urology 2018 18:24

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  37. Content type: Research article

    There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis.

    Authors: Dong Fang, Shiming He, Gengyan Xiong, Nirmish Singla, Zhenpeng Cao, Lei Zhang, Xuesong Li and Liqun Zhou

    Citation: BMC Urology 2018 18:22

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  38. Content type: Research article

    To evaluate the prognostic significance of the novel index combining preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in renal cell carcinoma (RCC) patients.

    Authors: Ding Peng, Cui-jian Zhang, Qi Tang, Lei Zhang, Kai-wei Yang, Xiao-teng Yu, Yanqing Gong, Xue-song Li, Zhi-song He and Li-qun Zhou

    Citation: BMC Urology 2018 18:20

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  39. Content type: Research article

    The non-invasive Cxbladder urine test system has demonstrated clinical utility in ruling out urothelial carcinoma (UC) in patients with asymptomatic microscopic hematuria (AMH), suggesting that the number of i...

    Authors: Tony Lough, Qingyang Luo, Carthika Luxmanan, Alastair Anderson, Jimmy Suttie, Paul O’Sullivan and David Darling

    Citation: BMC Urology 2018 18:18

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  40. Content type: Research article

    Due to the lack of strong evidence to identify the relationship between antihypertensive drugs use and the risk of prostate cancer, it was needed to do a systematic review to go into the subject.

    Authors: Liang Cao, Sha Zhang, Cheng-ming Jia, Wei He, Lei-tao Wu, Ying-qi Li, Wen Wang, Zhe Li and Jing Ma

    Citation: BMC Urology 2018 18:17

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  41. Content type: Research article

    Positive surgical margin (PSM) is a predictor of biochemical recurrence (BCR) following radical prostatectomy (RP). Attempts to stratify PSM based on linear length, Gleason score, location and number have fail...

    Authors: Mohammed Shahait, Samer Nassif, Hani Tamim, Deborah Mukherji, Maya Hijazi, Marwan El Sabban, Raja Khauli, Muhammad Bulbul, Wassim Abou Kheir and Albert El Hajj

    Citation: BMC Urology 2018 18:13

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  42. Content type: Research article

    This study aimed investigate the effect of the level of invasion into fibromuscular band (FMB) of prostate on the positive surgical margin (PSM) and biochemical recurrence (BCR) after radical prostatectomy (RP...

    Authors: Aram Kim, Myong Kim, Se Un Jeong, Cheryn Song, Yong Mee Cho, Jae Yoon Ro and Hanjong Ahn

    Citation: BMC Urology 2018 18:7

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  43. Content type: Research article

    Although numerous studies have shown that perineural invasion (PNI) is linked to prostate cancer (PCa) risk, the results have been inconsistent. This study aimed to explore the association between PNI and bioc...

    Authors: Li-jin Zhang, Bin Wu, Zhen-lei Zha, Wei Qu, Hu Zhao, Jun Yuan and Ye-jun Feng

    Citation: BMC Urology 2018 18:5

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  44. Content type: Research article

    Prostate cancer is one of the most common cancers in the elderly population. The standard treatment is radical prostatectomy (RARP). However, urologists do not have consents on the postoperative urine drainage...

    Authors: Zhongyu Jian, Shijian Feng, Yuntian Chen, Xin Wei, Deyi Luo, Hong Li and Kunjie Wang

    Citation: BMC Urology 2018 18:1

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  45. Content type: Research article

    This study compared the detection rates for clinically significant prostate cancer (CSPC) between magnetic resonance imaging and ultrasonography (MRI/US)-fusion-targeted biopsy (TB), systematic biopsy (SB) and...

    Authors: Yuji Hakozaki, Hisashi Matsushima, Jimpei Kumagai, Taro Murata, Tomoko Masuda, Yoko Hirai, Mai Oda, Nobuo Kawauchi, Munehiro Yokoyama and Yukio Homma

    Citation: BMC Urology 2017 17:117

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