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Urological oncology

This section considers clinical studies relevant to oncological disorders in urology

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  3. Currently, immunotherapy is indicated for patients with metastatic RCC or unresectable RCC, but there is no indication for immunotherapy in the neoadjuvant setting. We report a case in which the combined use o...

    Authors: Kenichi Nishimura, Noriyoshi Miura, Naoya Sugihara, Keisuke Funaki, Kanae Koyama, Yuichiro Sawada, Terutaka Noda, Tetsuya Fukumoto, Yuki Miyauchi, Tadahiko Kikugawa, Takashi Saika, Masafumi Matsumura, Katsuyoshi Hashine and Mashio Taniwaki

    Citation: BMC Urology 2021 21:124

    Content type: Case report

    Published on:

  4. The optimal management of clinical T4 (cT4) prostate cancer (PC) is still uncertain. At our institution, carbon ion radiotherapy (CIRT) for nonmetastatic PC, including tumors invading the bladder, has been pe...

    Authors: Yuhei Miyasaka, Hidemasa Kawamura, Hiro Sato, Nobuteru Kubo, Tatsuji Mizukami, Hiroshi Matsui, Yoshiyuki Miyazawa, Kazuto Ito, Takashi Nakano, Kazuhiro Suzuki and Tatsuya Ohno

    Citation: BMC Urology 2021 21:106

    Content type: Research article

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  5. Bladder cancer (BC) is the second most frequent malignancy of the urinary system. The aim of this study was to identify key microRNAs (miRNAs) and hub genes associated with BC as well as analyse their targeted...

    Authors: Hongjian Wu, Wubing Jiang, Guanghua Ji, Rong Xu, Gaobo Zhou and Hongyuan Yu

    Citation: BMC Urology 2021 21:90

    Content type: Research article

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  6. Intra-operative cell salvage (IOCS) and leukocyte-depleted filter (LDF) are widely used and effective in saving blood. However, the safety issue concerning reinfusion of IOCS–LDF processed blood to renal cell ...

    Authors: Xiaoqing Zhang, Xiangyang Guo, Yanan Zong, Chuanya Xu, Jilian Wang, Bin Zhang, Chang Liu, Yueqing Gong, Lixiang Xue, Lulin Ma, Shudong Zhang, Yi Li and Hong Zeng

    Citation: BMC Urology 2021 21:89

    Content type: Research article

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  7. Renal Cell Carcinoma (RCC) metastasizes in approximately 20–30% cases. The most common sites for metastases are the lungs, bones, liver, and brain. Metastases of RCC in the gastrointestinal tract (GIT) are ver...

    Authors: Jamshid Abdul-Ghafar, Nasir Ud Din, Ramin Saadaat and Zubair Ahmad

    Citation: BMC Urology 2021 21:84

    Content type: Research article

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  8. To investigate the role of mpMRI and high PIRADS score as independent triggers in the qualification of patients with ISUP 1 prostate cancer on biopsy to radical prostatectomy.

    Authors: Łukasz Nyk, Omar Tayara, Tomasz Ząbkowski, Piotr Kryst, Aneta Andrychowicz and Wojciech Malewski

    Citation: BMC Urology 2021 21:82

    Content type: Research article

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  9. Simultaneous urothelial cancer manifestation in the lower and upper urinary tract affects approximately 2% of patients. Data on the surgical benchmarks and mid-term oncological outcomes of enbloc robot-assiste...

    Authors: Stephan Buse, Assen Alexandrov, Elio Mazzone, Alexandre Mottrie and Axel Haferkamp

    Citation: BMC Urology 2021 21:73

    Content type: Research article

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  10. Inflammatory response biomarkers have been studied as promising prognostic factors in renal cell carcinoma, but few studies have focused on papillary renal cell carcinoma (PRCC). This study was performed to ev...

    Authors: Zhilei Zhang, Yongbo Yu, Jilu Zheng, Mingxin Zhang and Haitao Niu

    Citation: BMC Urology 2021 21:43

    Content type: Research article

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  11. Emerging evidence suggests that microRNAs (miRNAs) play multiple roles in human cancers through regulating mRNAs and distinct pathways. This paper focused on the functions of miR-4429 in prostate cancer (PCa) ...

    Authors: Jinguo Wang, Sheng Xie, Jun Liu, Tao Li, Wanrong Wang and Ziping Xie

    Citation: BMC Urology 2021 21:40

    Content type: Research article

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  12. WW Domain Containing Oxidoreductase (WWOX) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (...

    Authors: Żaneta Kałuzińska, Damian Kołat, Katarzyna Kośla, Magdalena Orzechowska, Andrzej K. Bednarek and Elżbieta Płuciennik

    Citation: BMC Urology 2021 21:36

    Content type: Research article

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  13. This study aimed to determine the prognostic value of preoperative blood parameters in renal cell carcinoma (RCC) and tumour thrombus (TT) patients that were surgically treated.

    Authors: Ruotao Xiao, Chuxiao Xu, Wei He, Lei Liu, Hongxian Zhang, Cheng Liu and Lulin Ma

    Citation: BMC Urology 2021 21:31

    Content type: Research article

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  15. A history of prior cancer commonly results in exclusion from cancer clinical trials. However, whether a prior cancer history has an adversely impact on clinical outcomes for patients with advanced prostate can...

    Authors: Yechen Wu, Xi Chen, Duocheng Qian, Wei Wang, Yiping Zhang, Jinxin Hu, Jun Zhu, Qiang Wu and Tinghu Cao

    Citation: BMC Urology 2021 21:26

    Content type: Research article

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  16. Previous findings indicate that pre-emptive pregabalin as part of multimodal anesthesia reduces opioid requirements compared to conventional anesthesia in patients undergoing robot-assisted laparoscopic prosta...

    Authors: K. Sisa, S. Huoponen, O. Ettala, H. Antila, T. I. Saari and P. Uusalo

    Citation: BMC Urology 2021 21:14

    Content type: Research article

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  17. Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic ...

    Authors: Dong In Jo, Song Hyun Han, Soon Heum Kim, Hye Young Kim, Hong Chung and Hong Sup Kim

    Citation: BMC Urology 2021 21:13

    Content type: Research article

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  18. Emerging evidence has noted the important participation of microRNAs (miRNAs) in several human diseases including cancer. This research was launched to probe the function of miR-381 in bladder cancer (BCa) pro...

    Authors: Dayin Chen, Liang Cheng, Huifeng Cao and Wensi Liu

    Citation: BMC Urology 2021 21:5

    Content type: Research article

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  19. To explore the rate of Gleason sum upgrading (GSU) from biopsy to radical prostatectomy pathology and to develop a nomogram for predicting the probability of GSU in a Chinese cohort.

    Authors: Xiaochuan Wang, Yu Zhang, Fengbo Zhang, Zhengguo Ji, Peiqian Yang and Ye Tian

    Citation: BMC Urology 2021 21:3

    Content type: Research article

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  20. Within the last decade, robotically-assisted laparoscopic prostatectomy (RALP) has become the standard for treating localized prostate cancer, causing a revival of the 45° Trendelenburg position. In this pilot...

    Authors: Clemens Wiesinger, Dominik Stefan Schoeb, Mathias Stockhammer, Emir Mirtezani, Lukas Mitterschiffthaler, Helga Wagner, Johann Knotzer and Walter Pauer

    Citation: BMC Urology 2020 20:198

    Content type: Research article

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  21. The neuroendocrine cells can cause a variety of malignancies throughout the human body known as the neuroendocrine tumors (NETs) or carcinoid tumors. The primary testicular carcinoid tumor (PTCT) accounts for ...

    Authors: Eugen Widmeier, Hannah Füllgraf and Cornelius F. Waller

    Citation: BMC Urology 2020 20:197

    Content type: Case report

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  22. Data are scarce regarding intravesical maintenance therapy (MT) with the low-dose bacillus Calmette–Guérin (BCG) Tokyo strain. We investigated the efficacy and safety of MT with a half dose of the Tokyo strain...

    Authors: Dai Koguchi, Kazumasa Matsumoto, Takahiro Hirayama, Shigetaka Moroo, Momoko Kobayashi, Hiroki Katsumata, Masaomi Ikeda and Masatsugu Iwamura

    Citation: BMC Urology 2020 20:194

    Content type: Research article

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  24. Kidney cancer is often asymptomatic, leading to proposals for a screening programme. The views of the public towards introducing a new screening programme for kidney cancer are unknown. The aim of this study w...

    Authors: Laragh L. W. Harvey-Kelly, Hannah Harrison, Sabrina H. Rossi, Simon J. Griffin, Grant D. Stewart and Juliet A. Usher-Smith

    Citation: BMC Urology 2020 20:170

    Content type: Research article

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  25. The Expanded Prostate Index Composite for Clinical Practice (EPIC-CP) is a short version of the original EPIC, developed to facilitate the instrument’s use in routine care. This study aimed to validate the EPI...

    Authors: Danilo B. Lourenço, Breno Santos Amaral, Wladimir Alfer-Junior, Ana Vasconcellos, Fernanda Russo, Rafael Sanchez-Salas, Bianca Bianco, Andrew A. Wagner, Peter Chang, Marcio Covas Moschovas, Gustavo Caserta Lemos and Arie Carneiro

    Citation: BMC Urology 2020 20:163

    Content type: Research article

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  26. The metastasis-associated gene 1 (MTA1) has been extensively reported as a crucial oncogene, and its abnormal expression has been associated with the progression of numerous cancers. However, the role of MTA1 ...

    Authors: Cai Lv, Yuan Huang, Qingqing Lei, Zhenxiang Liu, Shixing Shen and Wenxia Si

    Citation: BMC Urology 2020 20:160

    Content type: Research article

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  28. We aimed to explore the utility of prostate specific antigen (PSA) isoform [− 2] proPSA and its derivatives for prediction of pathological outcome after radical prostatectomy (RP).

    Authors: Vojtech Novak, Stepan Vesely, Hana Luksanová, Richard Prusa, Otakar Capoun, Vojtech Fiala, Olga Dolejsová, Hana Sedlacková, Radek Kucera, Jiri Stejskal, Miroslav Zalesky and Marko Babjuk

    Citation: BMC Urology 2020 20:144

    Content type: Research article

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  29. Metastatic spinal cord compression (MSCC) from prostate cancer (PC) influences not only patients’ prognosis but also their quality of life. However, little is known about the clinical outcome of surgery for MS...

    Authors: Yasuhide Miyoshi, Takashi Kawahara, Masahiro Yao and Hiroji Uemura

    Citation: BMC Urology 2020 20:143

    Content type: Research article

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  30. A higher incidence of apalutamide-related skin rash has been observed in Japanese patients with prostate cancer (PC).

    Authors: Hiroji Uemura, Yosuke Koroki, Yuki Iwaki, Keiichiro Imanaka, Takeshi Kambara, Angela Lopez-Gitlitz, Andressa Smith and Hirotsugu Uemura

    Citation: BMC Urology 2020 20:139

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Urology 2020 20:166

  31. Initial prostate biopsy often fails to identify prostate cancer resulting in patient anxiety, especially when clinical features such as prostate specific antigen (PSA) remain elevated, leading to the need for ...

    Authors: James McKiernan, Mikkel Noerholm, Vasisht Tadigotla, Sonia Kumar, Phillipp Torkler, Grannum Sant, Jason Alter, Michael J. Donovan and Johan Skog

    Citation: BMC Urology 2020 20:138

    Content type: Research article

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  32. Although the albumin-to-globulin ratio (AGR) is a promising biomarker for various malignancies, few studies have investigated its prognostic significance for upper tract urothelial carcinoma (UTUC).

    Authors: Shota Omura, Satoru Taguchi, Shogo Miyagawa, Ryuki Matsumoto, Mio Samejima, Naoki Ninomiya, Kazuki Masuda, Yu Nakamura, Tsuyoshi Yamaguchi, Manami Kinjo, Mitsuhiro Tambo, Takatsugu Okegawa, Eiji Higashihara and Hiroshi Fukuhara

    Citation: BMC Urology 2020 20:133

    Content type: Research article

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  33. Xp11.2 translocation renal cell carcinoma (tRCC) is recently recognized. As Xp11.2 tRCC involved gene translocation and fusion in X chromosome and the number of X chromosomes in female is twice of male, we won...

    Authors: Wenyuan Zhuang, Ning Liu, Hongqian Guo, Chunni Zhang and Weidong Gan

    Citation: BMC Urology 2020 20:130

    Content type: Research article

    Published on:

  34. Seminoma accounts for 30–50% of testicular germ cell tumors (TGCT)—the most common solid malignancy in men aged 15–35 years. The American Joint Committee on Cancer (AJCC) 8th edition (2018) created the subclas...

    Authors: Mário Fontes-Sousa, João Lobo, Helena Magalhães, João Cassis, Mariana Malheiro, Sância Ramos, Rui Henrique, Ana Martins and Maria Joaquina Maurício

    Citation: BMC Urology 2020 20:127

    Content type: Research article

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  35. This study aimed to assess the feasibility of a pan-cancer panel assay for high-risk renal cell carcinoma (RCC) in the Korean population. We also analyzed the clinical and genetic factors contributing to metas...

    Authors: Jungyo Suh, Chang Wook Jeong, Seongmin Choi, Ja Hyeon Ku, Hyeon Hoe Kim, Kwangsoo Kim and Cheol Kwak

    Citation: BMC Urology 2020 20:125

    Content type: Research article

    Published on:

  36. Hyperglycemia is associated with series of process leading to oncogenesis. Evidence has shown that diabetes mellitus (DM) seems to be associated with poor prognosis in patients with bladder cancer. However, ev...

    Authors: Wei-Lun Huang, Kuo-How Huang, Chao-Yuan Huang, Yeong-Shiau Pu, Hong-Chiang Chang and Po-Ming Chow

    Citation: BMC Urology 2020 20:117

    Content type: Research article

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  37. To compare the postoperative continence and clinical outcomes of Retzius-sparing robot-assisted laparoscopic radical prostatectomy (RS-RALP) with non-RS RALP for patients with prostate cancer.

    Authors: Yu-Li Jiang, Gao-Feng Zheng, Ze-Peng Jiang, Zhen-Li, Xie-Lai Zhou, Jin Zhou, Chun-Hua Ye and Kang-Er Wang

    Citation: BMC Urology 2020 20:114

    Content type: Research article

    Published on:

  38. The neutrophil-lymphocyte ratio (NLR) is a well-known prognostic marker in various cancers. However, its role as a predictive marker for the effectiveness of nivolumab in patients with metastatic RCC (mRCC) re...

    Authors: Naotaka Nishiyama, Megumi hirobe, Takuya Kikushima, Masahiro Matsuki, Atsushi Takahashi, Masahiro Yanase, Keisuke Ichimatsu, Masayuki Egawa, Norihiro Hayashi, Takahito Negishi, Naoya Masumori and Hiroshi Kitamura

    Citation: BMC Urology 2020 20:110

    Content type: Research article

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  39. Stauffer Syndrome (SS) is a paraneoplastic disorder associated with renal cell carcinoma (RCC). First described by Herbert Maurice Stauffer in 1961, it is characterized by hepatic dysfunction in the absence of...

    Authors: Julian Chavarriaga, Nayib Fakih, Juan Cataño, Catalina Villaquiran, Santiago Rodriguez and German Patino

    Citation: BMC Urology 2020 20:105

    Content type: Case report

    Published on:

  40. To investigate the value of using contrast-enhanced transrectal ultrasound (CETRUS) to reduce unnecessary collection of biopsies during prostate cancer diagnosis and its utility in predicting biochemical recur...

    Authors: Hong-wei Zhao, Jian Li, Jia-Zheng Cao, Juan Lin, Zhu Wang, Jian-yao Lv, Jin-huan Wei, Zhen-hua Chen, Hao-hua Yao, Yi-hui Pan, Zhen-li Gao, Jun-hang Luo, Wei Chen, Lei Shi and Yong Fang

    Citation: BMC Urology 2020 20:100

    Content type: Research article

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  41. Mitomycin (MMC) has been frequently used as the compound for intravesical treatment. The relatively new pyrimidine analog gemcitabine (GEM) has exhibited anticancer effect on various solid cancers, such as the...

    Authors: Rongxin Li, Ye Li, Jun Song, Ke Gao, Kangning Chen, Xiaogang Yang, Yongqiang Ding, Xinlong Ma, Yang Wang, Weipeng Li, Yanan Wang, Zhiping Wang and Zhilong Dong

    Citation: BMC Urology 2020 20:97

    Content type: Research article

    Published on:

  42. Intravesical bacillus Calmette-Guerin (BCG) therapy is the treatment of choice for patients with T1 or high-grade superficial bladder cancer or those with carcinoma in situ after transurethral resection. A per...

    Authors: Che-Wei Hsu, Yi-Chun Chiu, Hsiao-Yun Hu, Yu-Hua Fan, Shih-Chi Hong and Wei-Ming Cheng

    Citation: BMC Urology 2020 20:91

    Content type: Research article

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  43. Numerous studies show that the pretreatment neutrophil-to-lymphocyte ratio (NLR) is associated with the prognosis of patients with RCC. However, their findings are inconsistent, urging us to explore the progno...

    Authors: Yuan Shao, Bo Wu, Wei Jia, Zikuan Zhang, Qian Chen and Dongwen Wang

    Citation: BMC Urology 2020 20:90

    Content type: Research article

    Published on:

  44. To evaluate demographic, clinical and pathological characteristics of small renal masses (SRM) (≤ 4 cm) in a Latin-American population provided by LARCG (Latin-American Renal Cancer Group) and analyze predicto...

    Authors: Thiago Camelo Mourão, Diego Abreu, Gustavo F. Carvalhal, Guillermo Gueglio, Walter H. da Costa, Vinicius Fernando Calsavara, Luis Meza-Montoya, Rubén G. Bengió, Carlos Scorticati, Ricardo Castillejos-Molina, Francisco Rodríguez-Covarrubias, Ana María Autran-Gómez, José Gadu Campos-Salcedo, Alejandro Nolazco, Carlos Ameri, Hamilton Zampolli…

    Citation: BMC Urology 2020 20:85

    Content type: Research article

    Published on:

  45. Several phase 3 studies reported positive results for combinations of Immune-Oncology (IO) and Vascular Endothelial Growth Factor (VEGF) targeted therapies in patients with metastatic clear cell Renal Cell Car...

    Authors: Yasser Ged, Ruby Gupta, Cihan Duzgol, Andrea Knezevic, Natalie Shapnik, Ritesh Kotecha, Martin H. Voss, Darren R. Feldman, Oguz Akin, Sujata Patil, Robert J. Motzer, Brian I. Rini and Chung-Han Lee

    Citation: BMC Urology 2020 20:84

    Content type: Research article

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  46. Partial ablation of the prostate using high-intensity focussed ultrasound (HIFU-PA) is a treatment option for localised prostate cancer. When local recurrence occurs, salvage robot-assisted radical prostatecto...

    Authors: James E. Thompson, Ashwin N. Sridhar, Greg Shaw, Prabhakar Rajan, Anna Mohammed, Timothy P. Briggs, Senthil Nathan, John D. Kelly and Prasanna Sooriakumaran

    Citation: BMC Urology 2020 20:81

    Content type: Research article

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  47. Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is a variant of urothelial carcinoma that carries a poor prognosis. The epithelial-mesenchymal transition (EMT) has been demonstrated to contribut...

    Authors: Shunichiro Nomura, Yasutomo Suzuki, Jun Akatsuka, Yuki Endo, Akira Shimizu, Tsutomu Hamasaki, Go Kimura and Yukihiro Kondo

    Citation: BMC Urology 2020 20:72

    Content type: Research article

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  48. Androgen deprivation therapy (ADT) is a standard treatment for advanced prostate cancer (PCa). However, PCa recurrence and progression rates during ADT are high. Until now, there has been no evidence regarding...

    Authors: Agus Rizal A. H. Hamid, Harun W. Kusuma Putra, Ningrum Paramita Sari, Putri Diana, Saras Serani Sesari, Eka Novita, Fajar Lamhot Gultom, Meilania Saraswati, Budiana Tanurahardja, Asmarinah, Rainy Umbas and Chaidir A. Mochtar

    Citation: BMC Urology 2020 20:71

    Content type: Research article

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  49. Bladder cancer (BC) treatment can have a detrimental effect on the sexual organs of patients and yet assessment of sexual health needs has been greatly overlooked for these patients compared to those who have ...

    Authors: Agustina Bessa, Rebecca Martin, Christel Häggström, Deborah Enting, Suzanne Amery, Muhammad Shamim Khan, Fidelma Cahill, Harriet Wylie, Samantha Broadhead, Kathryn Chatterton, Sachin Malde, Rajesh Nair, Ramesh Thurairaja, Pardeep Kumar, Anna Haire, Saran Green…

    Citation: BMC Urology 2020 20:64

    Content type: Research article

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  50. Xanthogranulomatous pyelonephritis (XGP) is an uncommon form of chronic pyelonephritis. Most patients of XGP are diffuse in radiology and the clinical features are typical.

    Authors: Xiaobo Ding, Gang Wang, Tiejun Wang, Xiaobo Ma and Yanbo Wang

    Citation: BMC Urology 2020 20:63

    Content type: Case report

    Published on:

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