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Urological oncology

This section considers clinical studies relevant to oncological disorders in urology

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  1. Second-line treatment for urothelial carcinoma (UC) patients is used if progression or failure after platinum-based chemotherapy occurs or if patients are cisplatin-unfit. However, there is still no widely acc...

    Authors: Huitao Wang, Jianhe Liu, Kewei Fang, Changxing Ke, Yongming Jiang, Guang Wang, Tongxin Yang, Tao Chen and Xin Shi

    Citation: BMC Urology 2019 19:125

    Content type: Research article

    Published on:

  2. Advances in systemic targeted therapies afford treatment opportunities in patients with metastatic renal cell carcinoma (RCC). Elderly patients with metastatic RCC present a subpopulation for consideration owi...

    Authors: Christopher S. Hollenbeak, Eric W. Schaefer, Justin Doan and Jay D. Raman

    Citation: BMC Urology 2019 19:123

    Content type: Research article

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  3. Predictive models that take race into account like the Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPT RC) and the new Prostate Biopsy Collaborative Group (PBCG) RC have been developed to equitably ...

    Authors: Samuel Carbunaru, Oluwarotimi S. Nettey, Pooja Gogana, Irene B. Helenowski, Borko Jovanovic, Maria Ruden, Courtney M. P. Hollowell, Roohollah Sharifi, Rick A. Kittles, Edward Schaeffer, Peter Gann and Adam B. Murphy

    Citation: BMC Urology 2019 19:121

    Content type: Research article

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  5. Metabolic syndrome (MetS) and serum prostate-specific antigen (PSA) levels are correlated. To investigate the underlying effect of MetS on PSA levels, the relationship between the major pathogenic factors of M...

    Authors: Bo-Wen Xia, Si-Cong Zhao, Zong-Ping Chen, Chao Chen, Tian-Shu Liu, Fan Yang and Yong Yan

    Citation: BMC Urology 2019 19:119

    Content type: Research article

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  6. Bladder cancer is a complex disease associated with high morbidity and mortality. Management of bladder cancer before radical cystectomy continues to be controversial. We compared the long-term efficacy of one...

    Authors: Wasilijiang Wahafu, Sai Liu, Wenbin Xu, Mengtong Wang, Qingbao He, Liming Song, Mingshuai Wang, Feiya Yang, Lin Hua, Yinong Niu and Nianzeng Xing

    Citation: BMC Urology 2019 19:117

    Content type: Research article

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  7. Pelvic floor muscle training (PFM) training for post-prostatectomy incontinence (PPI) is an important rehabilitative approach, but the evidence base is still evolving. We developed a novel PFM training program...

    Authors: Joanne E. Milios, Timothy R. Ackland and Daniel J. Green

    Citation: BMC Urology 2019 19:116

    Content type: Research article

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  8. Retzius-sparing robot-assisted laparoscopic radical prostatectomy (rsRARP) allows entire prostatectomy procedure via the pouch of Douglas. In low- and intermediate-risk prostate cancer (PCa) there is level 1 e...

    Authors: Joanne Nyaboe Nyarangi-Dix, Magdalena Görtz, Georgi Gradinarov, Luisa Hofer, Viktoria Schütz, Claudia Gasch, Jan Philipp Radtke and Markus Hohenfellner

    Citation: BMC Urology 2019 19:113

    Content type: Research article

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  9. To report a new standardized cognitive fusion technique on transperineal targeted biopsy (TB) of prostate, and to evaluate its efficacy for cancer detection combined with systematic biopsy (SB) .

    Authors: Lei Wang, Xiaofei Wang, Wenfeng Zhao, Zichen Zhao, Zhihu Li, Shengmin Fei, He Zhu, Xiang Ji, Bing Yang, Ningchen Li and Yanqun Na

    Citation: BMC Urology 2019 19:107

    Content type: Research article

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  10. Prostate biopsy remains the gold standard approach to verify prostate cancer diagnosis. Transrectal (TR) biopsy is a regular modality, while transperineal (TP) biopsy is an alternative for the patients who dis...

    Authors: Guan-Lin Huang, Chih-Hsiung Kang, Wei-Ching Lee and Po-Hui Chiang

    Citation: BMC Urology 2019 19:101

    Content type: Research article

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  11. Robotic stereotactic ablative radiotherapy (SABR) is currently under investigation as a noninvasive treatment option for patients with renal cell carcinoma (RCC). For radiation therapy of RCC, tumor motion and...

    Authors: C. Senger, A. Conti, A. Kluge, D. Pasemann, M. Kufeld, G. Acker, M. Lukas, A. Grün, G. Kalinauskaite, V. Budach, J. Waiser and C. Stromberger

    Citation: BMC Urology 2019 19:96

    Content type: Research article

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  12. Accurate grading at the time of diagnosis if fundamental to risk stratification and treatment decision making in patients with prostate cancer. Whilst previous studies have demonstrated significant pathologica...

    Authors: Nicholas Bullock, Andrew Simpkin, Sarah Fowler, Murali Varma, Howard Kynaston and Krishna Narahari

    Citation: BMC Urology 2019 19:94

    Content type: Research article

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  13. Fatigue is one of the most prevalent symptoms among cancer patients. Specifically, in metastatic castration-resistant prostate cancer (mCRPC) patients, fatigue is the most common adverse event associated with ...

    Authors: A. Rodríguez Antolín, L. Martínez-Piñeiro, M. E. Jiménez Romero, J. B. García Ramos, D. López Bellido, J. Muñoz del Toro, A. García García-Porrero and F. Gómez Veiga

    Citation: BMC Urology 2019 19:92

    Content type: Research article

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  14. Because of the failure, shortage and related toxicities of Bacillus Calmette-Guérin (BCG), the other intravesical chemotherapy drugs are also widely used in clinical application. Gemcitabine and anthracycline ...

    Authors: Tian-Wei Wang, Hui Yuan, Wen-Li Diao, Rong Yang, Xiao-Zhi Zhao and Hong-Qian Guo

    Citation: BMC Urology 2019 19:90

    Content type: Research article

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  15. A variety of penile rehabilitation (PR) therapies are available to improve post-prostatectomy erectile dysfunction (ED) with mixed results. It is uncertain how adherent men are to PR therapies. The aim of this...

    Authors: Jeffrey Albaugh, Brittany Adamic, Cecilia Chang, Nicholas Kirwen and Joshua Aizen

    Citation: BMC Urology 2019 19:89

    Content type: Research article

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  16. We investigated the impact of postoperative membranous urethral length and other anatomic characteristics of the pelvic floor shape as measured by magnetic resonance imaging on the improvement in continence fo...

    Authors: Akihiro Nakane, Hiroki Kubota, Yusuke Noda, Tomoki Takeda, Yasuhiko Hirose, Atsushi Okada, Kentaro Mizuno, Noriyasu Kawai, Keiichi Tozawa, Yutaro Hayashi and Takahiro Yasui

    Citation: BMC Urology 2019 19:87

    Content type: Research article

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  17. There is an increased incidence of renal cell carcinoma (RCC) in patients with metabolic syndrome who usually have high levels of serum triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C). P...

    Authors: Emre Karabay, Nejdet Karsiyakali, Serdar Duvar, Cagatay Tosun, Ahmet Ruknettin Aslan and Omer Ergin Yucebas

    Citation: BMC Urology 2019 19:85

    Content type: Research article

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  18. In patients presenting with limited nodal recurrence following radical prostatectomy (RP), stereotactic body radiotherapy (SBRT) results might improve with a better case selection.

    Authors: Christoph Oehler, Michel Zimmermann, Lukas Adam, Juergen Curschmann, Marcin Sumila, Räto T. Strebel, Richard Cathomas, Qiyu Li, Uwe Schneider and Daniel R. Zwahlen

    Citation: BMC Urology 2019 19:84

    Content type: Research article

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  19. Perivesical lymph nodes (PVLNs) are occasionally isolated during grossing of cystectomy specimens. However, the prognostic implications of the involvement of PVLNs in bladder cancer patients, especially those ...

    Authors: Meenal Sharma, Takuro Goto, Zhiming Yang and Hiroshi Miyamoto

    Citation: BMC Urology 2019 19:77

    Content type: Research article

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  21. Strong evidence comparing effectiveness between nephron-sparing intervention (NSI) and active surveillance (AS) is lacking. Thus, we aim to compare the outcomes of survival, including cancer-specific survival ...

    Authors: Run-Qi Guo and Xiao-Guang Li

    Citation: BMC Urology 2019 19:74

    Content type: Research article

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  22. Patient-related factors such as concern about cancer are believed to influence both men’s decisions to undergo prostate specific antigen (PSA) testing and to have definitive treatment if diagnosed with low ris...

    Authors: Kerri Beckmann, Netty Kinsella, Henrik Olsson, Anna Wallerstedt Lantz, Tobias Nordstrom, Markus Aly, Jan Adolfsson, Martin Eklund and Mieke Van Hemelrijck

    Citation: BMC Urology 2019 19:73

    Content type: Research article

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  23. Due to the usage of various measurement methods and definitions, comparing continence rates after radical prostatectomy is a challenging task. This study compares continence rates based on different methods an...

    Authors: Sigrun Holze, Meinhard Mende, Karl V. Healy, Norbert Koehler, Lutz Gansera, Michael C. Truss, Udo Rebmann, Stephan Degener and Jens-Uwe Stolzenburg

    Citation: BMC Urology 2019 19:70

    Content type: Research article

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  24. The expression level of ribonucleotide reductase subunit M1 (RRM1) is closely related to the effect of gemcitabine-based therapy in advanced bladder cancer. However, the value of RRM1 expression in predicting ...

    Authors: Zhenxing Yang, Bingqiang Fu, Luqiang Zhou, Jie Xu, Ping Hao and Zhenqiang Fang

    Citation: BMC Urology 2019 19:69

    Content type: Research article

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  25. Epithelial cell adhesion molecule (EpCAM) expression has been reported in many types of cancer, including prostate cancer (PCa). However, the role of EpCAM expression remains inconsistent. We conducted a meta-...

    Authors: Yu Hu, Qiong Wu, Jialin Gao, Yongrui Zhang and Yuantao Wang

    Citation: BMC Urology 2019 19:67

    Content type: Research article

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  26. To evaluate the efficacy of pelvic plexus block (PPB) in relief pain during transperineal template-guided prostate biopsy (TTPB), compared with conventional periprostatic nerve block (PNB).

    Authors: Xue-fei Ding, Tian-bao Huang, Sheng-ming Lu, Hua-zhi Tao, Xiao-fang Ye, Fei Wang, Yao-zong Xu, Jia-nan Xu, Yu-quan Zhou and Yang Luan

    Citation: BMC Urology 2019 19:63

    Content type: Research article

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  27. Despite the fact that testicular cancer presents good prognosis, wide variations in mortality rates have been reported internationally. In Brazil, mortality trends and estimates have not been fully assessed. T...

    Authors: Samara Carollyne Mafra Soares, Katarina Márcia Rodrigues dos Santos, Fabia Cheyenne Gomes de Morais Fernandes, Isabelle Ribeiro Barbosa and Dyego Leandro Bezerra de Souza

    Citation: BMC Urology 2019 19:59

    Content type: Research article

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  28. There is a change in the position of the remaining anatomical structures of the lower urinary tract system following radical prostatectomy. The aims of this investigation were to describe three novel methods u...

    Authors: Hong Koo Ha, Henk B. Luiting, Petra L. Graham, Manish I. Patel, Jaspreet S. Sandhu, Oguz Akin and Sean F. Mungovan

    Citation: BMC Urology 2019 19:54

    Content type: Technical advance

    Published on:

  29. Let-7 is one of the earliest discovered microRNAs(miRNAs) and has been reported to be down-regulated in multiple malignant tumors. The effects and molecular mechanisms of let-7i in bladder cancer are still unc...

    Authors: M-M Qin, X. Chai, H-B Huang, G. Feng, X-N Li, J. Zhang, R. Zheng, X-C Liu and C. Pu

    Citation: BMC Urology 2019 19:53

    Content type: Research article

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  30. Testicular epidermoid cysts (TECs) are rare benign testicular neoplasms. As TECs are rarely associated with germ cell tumours (GCTs), the understanding of biological behaviour and clinical management of TEC is...

    Authors: Petra Anheuser, J. Kranz, E. Stolle, D. Höflmayer, F. Büscheck, S. Mühlstädt, G. Lock and K. P. Dieckmann

    Citation: BMC Urology 2019 19:52

    Content type: Research article

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  31. Physicians doubt percutaneous nephrostomy (PCN) insertion on cancer related hydronephrosis patients causes tumor seeding and worse cancer control. In this article, we attempted to determine if preoperative PCN...

    Authors: Guan-Lin Huang, Hao-Lun Luo and Po-Hui Chiang

    Citation: BMC Urology 2019 19:50

    Content type: Research article

    Published on:

  32. Conflicting evidence exists regarding the effect of hypertension on the prognosis of metastatic renal cell carcinoma (mRCC) patients treated with tyrosine kinase inhibitors (TKIs). This study aimed to assess t...

    Authors: Yu Liu, Liang Zhou, Yuntian Chen, Banghua Liao, Donghui Ye, Kunjie Wang and Hong Li

    Citation: BMC Urology 2019 19:49

    Content type: Research article

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  33. The efficacy of partial nephrectomy (PN) for T1b renal cell carcinoma (RCC) is controversial. The oncological outcomes, the change in postoperative renal function and the perioperative complications are unclear.

    Authors: Yu-Li Jiang, Cheng-Xia Peng, Heng-Zi Wang and Lu-Jie Qian

    Citation: BMC Urology 2019 19:48

    Content type: Research article

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  34. The identification of appropriate biomarkers is essential to support important clinical decisions in patients with prostate cancer. The aim of our study was a systematic bioinformatical analysis of the mRNA ex...

    Authors: Anika Kremer, Tobias Kremer, Glen Kristiansen and Yuri Tolkach

    Citation: BMC Urology 2019 19:46

    Content type: Research article

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  35. Prostate cancer is the most commonly diagnosed cancer in men. Radiotherapy represents one major treatment option in different therapeutic settings. As patients increasingly rely on internet-based medical infor...

    Authors: S. Janssen, F. B. Fahlbusch, L. Käsmann, D. Rades and D. Vordermark

    Citation: BMC Urology 2019 19:42

    Content type: Research article

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  36. Intrafascial prostatectomy was a modified technique from the conventional nerve-sparing surgery in order to improve patients’ post-surgical continence and erectile function; however, ongoing controversy exists...

    Authors: Xiao Wang, Yiqi Wu, Jia Guo, Hui Chen, Xiaodong Weng and Xiuheng Liu

    Citation: BMC Urology 2019 19:41

    Content type: Research article

    Published on:

  37. To assess the prognostic value of the extent of positive surgical margins (PSM) following radical prostatectomy (RP) on biochemical recurrence (BR) with long-term follow-up.

    Authors: Yoann Koskas, François Lannes, Nicolas Branger, Sophie Giusiano, Nicolas Guibert, Géraldine Pignot, Jochen Walz, Dominique Rossi and Cyrille Bastide

    Citation: BMC Urology 2019 19:37

    Content type: Research article

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  38. In this era of precision medicine, the DNA damage response (DDR) pathway has been shown to be a viable target of intervention in metastatic castration-resistant prostate cancer (CRPC) as approximately one-thir...

    Authors: Isaac E. Kim Jr, Sinae Kim, Arnav Srivastava, Biren Saraiya, Tina Mayer, Wun-Jae Kim and Isaac Yi Kim

    Citation: BMC Urology 2019 19:33

    Content type: Research article

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  39. Results from randomized phase III trials have shown that thrice-weekly docetaxel added to androgen-deprivation therapy (ADT) has a significant impact on the survival of patients with metastatic castration-naïv...

    Authors: Sang Eun Yoon, Youjin Kim, Jangho Cho, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byoung Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Su Jin Lee and Se Hoon Park

    Citation: BMC Urology 2019 19:30

    Content type: Research article

    Published on:

  40. There is no criterion for determining whether female patients operated with cystectomy would benefit from hysterectomy. This study compares the oncological outcomes between female patients receiving uterus pre...

    Authors: Haiwen Huang, Bing Yan, Meixia Shang, Libo Liu, Han Hao and Zhijun Xi

    Citation: BMC Urology 2019 19:28

    Content type: Research article

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  42. To investigate the prognostic risk factors and postoperative recurrence of bladder cancer in patients with upper urinary tract urothelial carcinomas (UTUCs).

    Authors: Qingwei Wang, Tao Zhang, Junwei Wu, Jianguo Wen, Deshang Tao, Tingxiang Wan and Wen Zhu

    Citation: BMC Urology 2019 19:24

    Content type: Research article

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  43. New biological prognostic predictors have been studied; however, some factors have limited clinical application due to tissue-specific expression and high cost. There is the need for a promising predictive fac...

    Authors: Yun-Sok Ha, Sang Won Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Won Tae Kim, Wun-Jae Kim and Tae-Hwan Kim

    Citation: BMC Urology 2019 19:10

    Content type: Research article

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  44. Patients with newly diagnosed non-metastatic prostate adenocarcinoma are typically classified as at low, intermediate, or high risk of disease progression using blood prostate-specific antigen concentration, t...

    Authors: Wendy L. Johnston, Charles N. Catton and Carol J. Swallow

    Citation: BMC Urology 2019 19:4

    Content type: Research article

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  45. Optimal treatment of high-risk prostate cancer remains controversial. We aimed to compare treatment outcomes of prostate cancer patients treated with definitive external-beam radiotherapy (ExRT) or radical pro...

    Authors: Fundagul Andic, Volkan Izol, Serkan Gokcay, Hasan Suat Arslantas, Yildirim Bayazit, Hatice Coskun, Mustafa Zuhtu Tansug and Yasar Sertdemir

    Citation: BMC Urology 2019 19:3

    Content type: Research article

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  46. Previous studies have shown that albumin-related systemic inflammation is associated with the long-term prognosis of cancer, but the clinical significance of an early (≤ 7 days) post-operative serum albumin le...

    Authors: Yongquan Tang, Zhihong Liu, Jiayu Liang, Ruochen Zhang, Kan Wu, Zijun Zou, Chuan Zhou, Fuxun Zhang and Yiping Lu

    Citation: BMC Urology 2018 18:111

    Content type: Research article

    Published on:

  47. To evaluate the efficacy and safety of abiraterone acetate (AA) plus prednisone compared with prednisone alone in Asian patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC),...

    Authors: Liancheng Fan, Baijun Dong, Chenfei Chi, Yanqing Wang, Yiming Gong, Jianjun Sha, Jiahua Pan, Xun Shangguan, Yiran Huang, Lixin Zhou and Wei Xue

    Citation: BMC Urology 2018 18:110

    Content type: Research article

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  49. Epidermal growth factor receptor (EGFR) overexpression is believed to be associated with bladder cancer (BC) progression and poor clinical outcomes. In vivo studies have linked EGFR subcellular trafficking and...

    Authors: Ahmed M. Mansour, Mona Abdelrahim, Mahmoud Laymon, Mamdouh Elsherbeeny, Mohammed Sultan, Ahmed Shokeir, Ahmed Mosbah, Hassan Abol-Enein, Amira Awadalla, Eunho Cho, Vikram Sairam, Taeeun D. Park, Muhammad Shahid and Jayoung Kim

    Citation: BMC Urology 2018 18:100

    Content type: Research article

    Published on:

  50. Warm ischemia (WI) and bleeding constitute the main challenges for surgeons during laparoscopic partial nephrectomy (LPN). Current literature on the use of lasers for cutting and coagulation remains scarce and...

    Authors: Martin Drerup, Ahmed Magdy, Martina Hager, Daniela Colleselli, Thomas Kunit, Lukas Lusuardi, Günter Janetschek and Michael Mitterberger

    Citation: BMC Urology 2018 18:99

    Content type: Research article

    Published on:

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