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Urological oncology

This section considers clinical studies relevant to oncological disorders in urology

Page 3 of 4

  1. Content type: Research article

    Clinical benefit of axitinib as a first line agent to treat patients with metastatic renal cell carcinoma (mRCC), or locally advanced renal cell carcinoma (RCC) have not been clearly demonstrated. The aim of t...

    Authors: Takuya Koie, Chikara Ohyama, Takahiro Yoneyama, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Yasuhiro Hashimoto, Tohru Yoneyama, Yuki Tobisawa and Kazuyuki Mori

    Citation: BMC Urology 2015 15:32

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  2. Content type: Research article

    This study describes and compares health-related quality of life (HRQOL) of prostate cancer patients who received either radical prostatectomy (nerve-sparing, nsRP, or non-nerve-sparing, nnsRP) or radiotherapy...

    Authors: Nora Eisemann, Sandra Nolte, Maike Schnoor, Alexander Katalinic, Volker Rohde and Annika Waldmann

    Citation: BMC Urology 2015 15:28

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  3. Content type: Research article

    Radical prostatectomy is a standard surgical treatment of clinically localized prostate cancer. Margin status has been found to be an independent predictor of biochemical recurrence (BCR) after open radical pr...

    Authors: Ryuta Tanimoto, Yomi Fashola, Kymora B Scotland, Anne E Calvaresi, Leonard G Gomella, Edouard J Trabulsi and Costas D Lallas

    Citation: BMC Urology 2015 15:27

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  4. Content type: Research article

    To assess pathological correlations and temporal trends of Angiopoietin-2 (ANGPT2), vascular endothelial growth factor (VEGF) and M2 Pyruvate kinase (TuM2PK), markers of tumor vascular development and metaboli...

    Authors: Bishoy A Gayed, Jessica Gillen, Alana Christie, Samuel Peña-Llopis, Xian-Jin Xie, Jingsheng Yan, Jose A Karam, Ganesh Raj, Arthur I Sagalowsky, Yair Lotan, Vitaly Margulis and James Brugarolas

    Citation: BMC Urology 2015 15:24

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  5. Content type: Research article

    Hematuria can be symptomatic of urothelial carcinoma (UC) and ruling out patients with benign causes during primary evaluation is challenging. Patients with hematuria undergoing urological work-ups place signi...

    Authors: Laimonis Kavalieris, Paul J O’Sullivan, James M Suttie, Brent K Pownall, Peter J Gilling, Christophe Chemasle and David G Darling

    Citation: BMC Urology 2015 15:23

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  6. Content type: Case report

    Major life-threatening complications secondary to cisplatin-based chemotherapy are rare in patients with testicular germ cell tumour (GCT). The incidence of complications increases with dosage of chemotherapy ...

    Authors: Klaus-Peter Dieckmann, Petra Anheuser, Ralf Gehrckens, Sven Philip Aries, Raphael Ikogho and Wiebke Hollburg

    Citation: BMC Urology 2015 15:21

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  7. Content type: Case report

    Metastasis to penis usually arises from genitourinary organs, but in rare cases, metastasis comes from the sigmoid colon. Furthermore, very few cases of penile metastasis of primary sigmoid colon carcinoma hav...

    Authors: Zhengbang Dong, Chao Qin, Qijie Zhang, Lei Zhang, Haijing Yang, Jingdong Zhang and Fei Wang

    Citation: BMC Urology 2015 15:20

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  8. Content type: Case report

    More than 429,000 patients worldwide are diagnosed with bladder cancer each year and muscle-invasive bladder cancer has an especially poor outcome. The median age at diagnosis is over 70 years, and many patien...

    Authors: Vicente Guillem, Miguel Angel Climent, Javier Cassinello, Emilio Esteban, Daniel Castellano, José Luis González-Larriba, Pablo Maroto and Carlos Camps

    Citation: BMC Urology 2015 15:15

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  9. Content type: Research article

    The loss of a testicle to cancer involves much emotional impact to young males. Little is known about the number of patients with testicular germ cell tumour (GCT) who would accept a testicular prosthesis. Als...

    Authors: Klaus-Peter Dieckmann, Petra Anheuser, Stefan Schmidt, Benjamin Soyka-Hundt, Uwe Pichlmeier, Philipp Schriefer, Cord Matthies, Michael Hartmann and Christian G Ruf

    Citation: BMC Urology 2015 15:16

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  10. Content type: Research article

    The human papillomavirus (HPV) prevalence in males has been reported to be between 3.6% and 84%, depending specially on the socioeconomic status. HPV infection has been related as a risk factor for penile canc...

    Authors: Isaura Danielli Borges de Sousa, Flávia Castello Branco Vidal, João Paulo Castello Branco Vidal, George Castro Figueira de Mello, Maria do Desterro Soares Brandão Nascimento and Luciane Maria Oliveira Brito

    Citation: BMC Urology 2015 15:13

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  11. Content type: Research article

    Adenocarcinoma of the urinary bladder is a rare malignancy. Radical surgery is suggested as the best available treatment for early-stage disease, but there is currently no consensus on standard chemotherapy re...

    Authors: Bin Yu, Jin Zhou, Hongzhou Cai, Ting Xu, Zicheng Xu, Qing Zou and Min Gu

    Citation: BMC Urology 2015 15:3

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  12. Content type: Case report

    Papillary renal cell carcinoma (pRCC) is a mixed group of tumors that constitutes about 15-20% of all renal cortical cancers. Strong enhancement on computerized tomography (CT) is a feature of clear cell, but ...

    Authors: Shaheen Alanee, Danuta I Dynda, Patrick Hemmer and Bradley Schwartz

    Citation: BMC Urology 2014 14:102

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  13. Content type: Research article

    Partial nephrectomy has been underutilized in the United States. We investigated national trends in partial nephrectomy (PN) utilization before and after publication of the American Urological Association (AUA...

    Authors: Michael A Liss, Song Wang, Kerrin Palazzi, Ramzi Jabaji, Nishant Patel, Hak J Lee, J Kellogg Parsons and Ithaar H Derweesh

    Citation: BMC Urology 2014 14:101

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  14. Content type: Research article

    To determine the relationship between renal cell carcinoma subtypes and the associated mortality and biochemical parameters. An additional aim was to analyze multiphasic multidetector computed tomography findi...

    Authors: Suat Keskin, Zeynep Keskin, Hakan Hakki Taskapu, Havva Kalkan, Mehmet Kaynar, Necdet Poyraz and Hatice Toy

    Citation: BMC Urology 2014 14:95

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  15. Content type: Case report

    Acanthosis nigricans is characterized by hyperpigmentation and hyperkeratosis of the skin or mucous membranes. Its malignant form is associated with internal neoplasms, especially gastric adenocarcinoma (55–61...

    Authors: Joanna Kubicka-Wołkowska, Sylwia Dębska-Szmich, Maja Lisik-Habib, Marcin Noweta and Piotr Potemski

    Citation: BMC Urology 2014 14:88

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  16. Content type: Research article

    Cystic renal cell carcinoma (CRCC) is relatively rare; CRCC is frequently misdiagnosed as a benign renal cyst. CRCC carries an excellent prognosis following surgical treatment. The aim of our study was to summ...

    Authors: Shanwen Chen, Baiye Jin, Liqi Xu, Guanghou Fu, Hongzhou Meng, Ben Liu, Jun Li and Dan Xia

    Citation: BMC Urology 2014 14:87

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  17. Content type: Research article

    The optimal timing of salvage androgen deprivation therapy (ADT) for biochemical recurrence after radical prostatectomy is controversial. We compared the outcomes of ultra-early versus early salvage ADT.

    Authors: Satoru Taguchi, Hiroshi Fukuhara, Takeshi Azuma, Motofumi Suzuki, Tetsuya Fujimura, Tohru Nakagawa, Akira Ishikawa, Haruki Kume, Yasuhiko Igawa and Yukio Homma

    Citation: BMC Urology 2014 14:81

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  18. Content type: Research article

    It is well recognized that the presence of positive surgical margins (PSM) after radical prostatectomy (RP) adversely affects cancer specific outcomes and recent evidence from randomized trials supports the us...

    Authors: Stepan Vesely, Ladislav Jarolim, Katerina Duskova, Marek Schmidt, Pavel Dusek and Marko Babjuk

    Citation: BMC Urology 2014 14:79

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  19. Content type: Case report

    Renal angiomyolipomas (AMLs) are frequent in tuberous sclerosis and are responsible for a significant proportion of the morbidity in adulthood, mainly from bleeding complications, which are correlated to the s...

    Authors: Thierry Krummel, Julien Garnon, Hervé Lang, Afshin Gangi and Thierry Hannedouche

    Citation: BMC Urology 2014 14:77

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  20. Content type: Research article

    Inflammation is a critical component of tumorigenesis, and many cancers arise from sites of infection, chronic irritation, and inflammation. Inflammatory cytokines triggered by tumors alter hematologic compone...

    Authors: Sally Temraz, Deborah Mukherji, Zein Al Abideen Farhat, Rami Nasr, Maya Charafeddine, Mohammed Shahait, Mohammad Rachad Wehbe, Rami Abou Ghaida, Ibrahim Abu Gheida and Ali Shamseddine

    Citation: BMC Urology 2014 14:76

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  21. Content type: Case report

    Cardiac metastases from renal cell carcinoma without vena caval involvement are extremely rare with a limited number of cases reported in the worldwide literature until now. Nevertheless, this rare location of...

    Authors: Anna M Czarnecka, Pawel Sobczuk, Fei Lian and Cezary Szczylik

    Citation: BMC Urology 2014 14:73

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  22. Content type: Research article

    The observed low metastatic potential and favorable survival of small incidentally detected renal cell carcinomas (RCCs) have been a part of the rationale for recommending partial nephrectomy as a first treatm...

    Authors: Johann P Ingimarsson, Martin I Sigurdsson, Sverrir Hardarson, Vigdis Petursdottir, Eirikur Jonsson, Gudmundur V Einarsson and Tomas Gudbjartsson

    Citation: BMC Urology 2014 14:72

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    The Erratum to this article has been published in BMC Urology 2015 15:5

  23. Content type: Research article

    Inducing endoplasmic reticulum (ER) stress is a novel strategy used to treat malignancies. Inhibition of histone deacetylase (HDAC) 6 by the HDAC inhibitor panobinostat hinders the refolding of unfolded protei...

    Authors: Akinori Sato, Takako Asano, Makoto Isono, Keiichi Ito and Tomohiko Asano

    Citation: BMC Urology 2014 14:71

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  24. Content type: Research article

    Bacillus Calmette-Guérin (BCG) is considered the most effective treatment to reduce recurrence and progression of non-muscle invasive bladder cancer (NMIBC) but can induce local side effects leading to treatme...

    Authors: Luca Topazio, Roberto Miano, Valentina Maurelli, Gabriele Gaziev, Mauro Gacci, Valerio Iacovelli and Enrico Finazzi-Agrò

    Citation: BMC Urology 2014 14:64

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  25. Content type: Research article

    Past attempts at detecting prostate cancer (PCa) cells in voided urine by traditional cytology have been impeded by undesirably low sensitivities but high specificities. To improve the sensitivities, we evalua...

    Authors: Yasushi Nakai, Satoshi Anai, Masaomi Kuwada, Makito Miyake, Yoshitomo Chihara, Nobumichi Tanaka, Akihide Hirayama, Katsunori Yoshida, Yoshihiko Hirao and Kiyohide Fujimoto

    Citation: BMC Urology 2014 14:59

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  26. Content type: Research article

    Gleason pattern 3 less often has molecular abnormalities and often behaves indolent. It is controversial whether low grade small foci of prostate cancer (PCa) on biopsy could avoid immediate treatment or not, ...

    Authors: Masahiro Yashi, Tomoya Mizuno, Hideo Yuki, Akinori Masuda, Tsunehito Kambara, Hironori Betsunoh, Hideyuki Abe, Yoshitatsu Fukabori, Osamu Muraishi, Koyu Suzuki, Yoshimasa Nakazato and Takao Kamai

    Citation: BMC Urology 2014 14:43

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  27. Content type: Research article

    The survival benefits of adrenalectomy (ADx) in the setting of metastatic cancer and prognostic factors for recurrence-free (RFS) and overall survival (OS) after adrenalectomy for metastatic carcinoma are stil...

    Authors: Eu Chang Hwang, Insang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Suk Hee Heo, Jun Eul Hwang, Sung Gu Kang, Seok Ho Kang, Jeong Gu Lee, Je Jong Kim and Jun Cheon

    Citation: BMC Urology 2014 14:41

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  28. Content type: Case report

    Seminomatous and non-seminomatous Germ Cell Tumors (GCT) of the testis are a rare cancer, with an estimated incidence of 56.3 per million white males and 10 per million black males in the United States.

    Authors: Pietro Rispoli, Paolo Destefanis, Paolo Garneri, Gianfranco Varetto, Beatrice Lillaz, Claudio Castagno, Patrizia Lista, Libero Ciuffreda and Dario Fontana

    Citation: BMC Urology 2014 14:40

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  29. Content type: Case report

    Mucin-producing urothelial-type adenocarcinoma of the prostatic urethra is extremely rare. These lesions must be differentiated from other mucinous tumors including mucin-producing prostatic adenocarcinoma and...

    Authors: Elisabeth M Sebesta, Hossein S Mirheydar, J Kellogg Parsons, Jessica Wang-Rodriguez and A Karim Kader

    Citation: BMC Urology 2014 14:39

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  30. Content type: Research article

    Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcino...

    Authors: Gustav Andersson, Christoffer Wennersten, Alexander Gaber, Karolina Boman, Björn Nodin, Mathias Uhlén, Ulrika Segersten, Per-Uno Malmström and Karin Jirström

    Citation: BMC Urology 2014 14:36

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  31. Content type: Research article

    The prostatic anterior zone (AZ) is not targeted routinely by TRUS guided prostate biopsy (TRUS-Pbx). MRI is an accurate diagnostic tool for AZ tumors, but is often unavailable due to cost or system restrictio...

    Authors: Eric Cole, David Margel, Michael Greenspan, Bobby Shayegan, Edward Matsumoto, Marc A Fischer, Michael Patlas, Dean Daya and Jehonathan H Pinthus

    Citation: BMC Urology 2014 14:34

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  32. Content type: Research article

    Primary androgen deprivation therapy (PADT) is the most effective systemic therapy for patients with metastatic prostate cancer. Nevertheless, once PSA progression develops, the prognosis is serious and mortal...

    Authors: Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao and Kiyohide Fujimoto

    Citation: BMC Urology 2014 14:33

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  33. Content type: Case report

    Schwannomas are tumours arising from Schwann cells, which sheath the peripheral nerves. Here, we report a rare case of left intrascrotal, extratesticular schwannoma. Although rare, scrotal localisation of schw...

    Authors: Giovanni Palleschi, Antonio Carbone, Jessica Cacciotti, Giorgia Manfredonia, Natale Porta, Andrea Fuschi, Cosimo de Nunzio, Vincenzo Petrozza and Antonio Luigi Pastore

    Citation: BMC Urology 2014 14:32

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  34. Content type: Research article

    Castration-resistant prostate cancer (CRPC) patients have poor prognoses, and docetaxel (DTX) is among the few treatment options. An accurate risk classification to identify CRPC patient groups for which DTX w...

    Authors: Kazuhiko Nakano, Kenji Komatsu, Taro Kubo, Shinsuke Natsui, Akinori Nukui, Shinsuke Kurokawa, Minoru Kobayashi and Tatsuo Morita

    Citation: BMC Urology 2014 14:31

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  35. Content type: Research article

    Recently, three prospective randomized trials have shown that adjuvant radiotherapy (ART) after radical prostatectomy for the patients with pT3 and/or positive margins improves biochemical progression-free sur...

    Authors: Jung Hun Kang, Yun-Sok Ha, Sung Kim, Jihyeong Yu, Neal Patel, Jaspreet S Parihar, Amirali Hassanzadeh Salmasi, Wun-Jae Kim and Isaac Yi Kim

    Citation: BMC Urology 2014 14:30

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  36. Content type: Research article

    In patients with early prostate cancer, stratification by comorbidity could be of importance in clinical decision making as well as in characterizing patients enrolled into clinical trials. In this study, we i...

    Authors: Michael Froehner, Anna-Elisa Kellner, Rainer Koch, Gustavo B Baretton, Oliver W Hakenberg and Manfred P Wirth

    Citation: BMC Urology 2014 14:28

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  37. Content type: Research article

    Tyrosine kinase inhibitors (TKIs) have been used as standard therapy for patients with advanced renal cell carcinoma (RCC). However, information on factors predicting response to treatment with TKIs is lacking...

    Authors: Norihiko Tsuchiya, Takeshi Yuasa, Shinya Maita, Shintaro Narita, Takamitsu Inoue, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, Junji Yonese and Tomonori Habuchi

    Citation: BMC Urology 2014 14:26

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  38. Content type: Research article

    Oncologic and functional outcomes after radical prostatectomy (RP) can vary between surgeons to a greater extent than is expected by chance. We sought to examine the effects of surgeon variation on functional ...

    Authors: Sigrid Carlsson, Anders Berglund, Daniel Sjoberg, Ali Khatami, Johan Stranne, Svante Bergdahl, Pär Lodding, Gunnar Aus, Andrew Vickers and Jonas Hugosson

    Citation: BMC Urology 2014 14:25

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  39. Content type: Research article

    Few studies to date have directly compared outcomes of retropubic (RRP) and laparoscopic (LRP) radical prostatectomy. We investigated a single institution experience with RRP and LRP with respect to functional...

    Authors: Ahmed Magheli, Jonas Busch, Natalia Leva, Mark Schrader, Serdar Deger, Kurt Miller and Michael Lein

    Citation: BMC Urology 2014 14:18

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  40. Content type: Research article

    The HOX genes are a family of transcription factors that help to determine cell and tissue identity during early development, and which are also over-expressed in a number of malignancies where they have been sho...

    Authors: Richard Morgan, Angie Boxall, Kevin J Harrington, Guy R Simpson, Agnieszka Michael and Hardev S Pandha

    Citation: BMC Urology 2014 14:17

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  41. Content type: Research article

    An association between cigarette smoking and increased risk of clear cell renal cell carcinoma (ccRCC) has been established; however, there are limited data regarding the molecular mechanisms that underlie thi...

    Authors: Jeanette E Eckel-Passow, Daniel J Serie, Brian M Bot, Richard W Joseph, John C Cheville and Alexander S Parker

    Citation: BMC Urology 2014 14:14

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  42. Content type: Research article

    Radical prostatectomy is used to treat patients with clinically localized prostate cancer, but there have been few reports of its use in locally advanced disease. We evaluated the long-term results of radical ...

    Authors: Yuzuri Tsurumaki Sato, Hiroshi Fukuhara, Motofumi Suzuki, Tetsuya Fujimura, Tohru Nakagawa, Hiroaki Nishimatsu, Haruki Kume, Teppei Morikawa, Masashi Fukayama and Yukio Homma

    Citation: BMC Urology 2014 14:13

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  43. Content type: Research article

    CXCL12/CXCR4 transactivation of epidermal growth factor family receptors in lipid raft membrane microdomains on cell surface is thought to mediate tumor growth and subsequent development of metastatic disease....

    Authors: Donald Wong, Pridvi Kandagatla, Walter Korz and Sreenivasa R Chinni

    Citation: BMC Urology 2014 14:12

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  44. Content type: Research article

    BCG-RIVM strain was used in many treatment protocols for non-muscle invasive bladder cancer only as induction courses. Cho et al. (Anticancer Res 2012) compared BCG-RIVM induction and 'standard' maintenance (Lamm...

    Authors: Naim B Farah, Rami Ghanem and Mahmoud Amr

    Citation: BMC Urology 2014 14:11

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  45. Content type: Research article

    Prospective studies suggested an association between pioglitazone (Actos) use and the development of bladder cancer. Cancer pathology among pioglitazone users has not been characterized. We chose to compare th...

    Authors: Victoriano Romero, Charles Peyton, Ian Gray, Ashok Hemal and Ryan Terlecki

    Citation: BMC Urology 2014 14:10

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