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Urological oncology

This section considers clinical studies relevant to oncological disorders in urology

Page 5 of 6

  1. [−2]proPSA and its derivatives have an higher diagnostic accuracy than PSA in predicting prostate cancer (PCa). In alternative to PSA, ultrasensitive PSA (uPSA) and [−2]proPSA could be potentially useful in re...

    Authors: S. De Luca, R. Passera, A. Sottile, C. Fiori, R. M. Scarpa and F. Porpiglia

    Citation: BMC Urology 2016 16:14

    Content type: Research article

    Published on:

  2. While novel drugs have been developed, docetaxel remains one of the standard initial systemic therapies for castration-resistant prostate cancer (CRPC) patients. Despite the excellent anti-tumor effect of doce...

    Authors: Shimpei Yamashita, Yasuo Kohjimoto, Takashi Iguchi, Hiroyuki Koike, Hiroki Kusumoto, Akinori Iba, Kazuro Kikkawa, Yoshiki Kodama, Nagahide Matsumura and Isao Hara

    Citation: BMC Urology 2016 16:13

    Content type: Research article

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  3. There is much interest in confirming whether the efficacy of abiraterone acetate (AA) demonstrated within the trial setting is reproducible in routine clinical practice. We report the clinical outcome of metas...

    Authors: Darren M. C. Poon, Kuen Chan, S. H. Lee, T. W. Chan, Henry Sze, Eric K. C. Lee, Daisy Lam and Michelle F. T. Chan

    Citation: BMC Urology 2016 16:12

    Content type: Research article

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  5. The high false negative rates for initial prostate biopsies refer a large number of the men for repeat biopsies each year. Therefore, biomarkers associated with high risk of the presence of malignancy in histo...

    Authors: Saeid Alinezhad, Riina-Minna Väänänen, Natalia Tong Ochoa, Emily A. Vertosick, Anders Bjartell, Peter J Boström, Pekka Taimen and Kim Pettersson

    Citation: BMC Urology 2016 16:10

    Content type: Research article

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  6. Lymphovascular invasion (LVI) is an important step in the process of tumor dissemination and metastasis outside the primary organ, but the relationship between LVI and the prognosis of T1 non-muscle invasive b...

    Authors: Keishiro Fukumoto, Eiji Kikuchi, Shuji Mikami, Akira Miyajima and Mototsugu Oya

    Citation: BMC Urology 2016 16:5

    Content type: Research article

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  7. Measurement of the prostate specific antigen (PSA) remains an important tool in prostate cancer (PC) diagnosis. Due to limited availability of laboratory devices in an outpatient setting, compact and easy-to-h...

    Authors: Steffen Rausch, Joerg Hennenlotter, Josef Wiesenreiter, Andrea Hohneder, Julian Heinkele, Christian Schwentner, Arnulf Stenzl and Tilman Todenhöfer

    Citation: BMC Urology 2016 16:4

    Content type: Research article

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  8. Current therapies for advanced renal cell carcinoma (RCC) have low cure rates or significant side effects. It has been reported that complexes composed of interleukin (IL)-2 and stimulating anti-IL-2 antibody ...

    Authors: Kyu-Hyun Han, Ki Won Kim, Ji-Jing Yan, Jae-Ghi Lee, Eun Mi Lee, Miyeon Han, Eun Jin Cho, Seong Sik Kang, Hye Jin Lim, Tai Yeon Koo, Curie Ahn and Jaeseok Yang

    Citation: BMC Urology 2016 16:2

    Content type: Research article

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  9. The American Urological Association (AUA) changed their Prostate-Specific Antigen (PSA) screening guidelines in 2013 to not recommend testing in men under 55 years of age without significant risk factors (such...

    Authors: Nandu D. Dantanarayana, Tania Hossack, Paul Cozzi, Andrew Brooks, Howard Lau, Warick Delprado and Manish I. Patel

    Citation: BMC Urology 2015 15:124

    Content type: Research article

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  10. Prostate cancer is the second most common diagnosed cancer in men. Due to the low specificity of current diagnosis methods for detecting prostate cancer, identification of new biomarkers is highly desirable. T...

    Authors: Jin Huang, Kathleen H. Reilly, Hui-Zhen Zhang and Hai-Bo Wang

    Citation: BMC Urology 2015 15:118

    Content type: Research article

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  12. Prostate cancer remains the most common cancer in men. Qualitative or semi-quantitative immunochromatographic measurements of prostate specific antigen (PSA) have been shown to be simple, noninvasive and feasi...

    Authors: Cheng-Ching Wu, Hung-Yu Lin, Chao-Ping Wang, Li-Fen Lu, Teng-Hung Yu, Wei-Chin Hung, Jer-Yiing Houng, Fu-Mei Chung, Yau-Jiunn Lee and Jin-Jia Hu

    Citation: BMC Urology 2015 15:109

    Content type: Research article

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  13. To investigate the efficacy of initial biopsy or transurethral resection of bladder tumor for detecting histological variants on radical cystectomy and to assess the prognostic significance of variant histolog...

    Authors: Peng Ge, Zi-Cheng Wang, Xi Yu, Jian Lin and Qun He

    Citation: BMC Urology 2015 15:46

    Content type: Research article

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  14. Urothelial carcinoma (UC) is a common cancer affecting many patients in the United States. Nephroureterectomy remains the gold standard for the treatment of high grade upper tract disease or low grade tumors t...

    Authors: Michael A. Moriarty, Matthew A. Uhlman, Megan T. Bing, Michael A. O’Donnell, James A. Brown, Chad R. Tracy, Sundeep Deorah, Kenneth G. Nepple and Amit Gupta

    Citation: BMC Urology 2015 15:45

    Content type: Research article

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  16. Adrenocortical carcinoma (ACC) is aggressive, but rare tumours that have not been sufficiently studied. The aim of our study was to present the demographic and clinical characteristics of patients with ACC, to...

    Authors: Zlatibor Loncar, Vladimir Djukic, Vladan Zivaljevic, Tatjana Pekmezovic, Aleksandar Diklic, Svetislav Tatic, Dusko Dundjerovic, Branislav Olujic, Nikola Slijepcevic and Ivan Paunovic

    Citation: BMC Urology 2015 15:43

    Content type: Research article

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  18. Clinical benefit of axitinib as a first line agent to treat patients with metastatic renal cell carcinoma (mRCC), or locally advanced renal cell carcinoma (RCC) have not been clearly demonstrated. The aim of t...

    Authors: Takuya Koie, Chikara Ohyama, Takahiro Yoneyama, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Yasuhiro Hashimoto, Tohru Yoneyama, Yuki Tobisawa and Kazuyuki Mori

    Citation: BMC Urology 2015 15:32

    Content type: Research article

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  19. This study describes and compares health-related quality of life (HRQOL) of prostate cancer patients who received either radical prostatectomy (nerve-sparing, nsRP, or non-nerve-sparing, nnsRP) or radiotherapy...

    Authors: Nora Eisemann, Sandra Nolte, Maike Schnoor, Alexander Katalinic, Volker Rohde and Annika Waldmann

    Citation: BMC Urology 2015 15:28

    Content type: Research article

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  20. Radical prostatectomy is a standard surgical treatment of clinically localized prostate cancer. Margin status has been found to be an independent predictor of biochemical recurrence (BCR) after open radical pr...

    Authors: Ryuta Tanimoto, Yomi Fashola, Kymora B Scotland, Anne E Calvaresi, Leonard G Gomella, Edouard J Trabulsi and Costas D Lallas

    Citation: BMC Urology 2015 15:27

    Content type: Research article

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  21. To assess pathological correlations and temporal trends of Angiopoietin-2 (ANGPT2), vascular endothelial growth factor (VEGF) and M2 Pyruvate kinase (TuM2PK), markers of tumor vascular development and metaboli...

    Authors: Bishoy A Gayed, Jessica Gillen, Alana Christie, Samuel Peña-Llopis, Xian-Jin Xie, Jingsheng Yan, Jose A Karam, Ganesh Raj, Arthur I Sagalowsky, Yair Lotan, Vitaly Margulis and James Brugarolas

    Citation: BMC Urology 2015 15:24

    Content type: Research article

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  22. Hematuria can be symptomatic of urothelial carcinoma (UC) and ruling out patients with benign causes during primary evaluation is challenging. Patients with hematuria undergoing urological work-ups place signi...

    Authors: Laimonis Kavalieris, Paul J O’Sullivan, James M Suttie, Brent K Pownall, Peter J Gilling, Christophe Chemasle and David G Darling

    Citation: BMC Urology 2015 15:23

    Content type: Research article

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  23. Major life-threatening complications secondary to cisplatin-based chemotherapy are rare in patients with testicular germ cell tumour (GCT). The incidence of complications increases with dosage of chemotherapy ...

    Authors: Klaus-Peter Dieckmann, Petra Anheuser, Ralf Gehrckens, Sven Philip Aries, Raphael Ikogho and Wiebke Hollburg

    Citation: BMC Urology 2015 15:21

    Content type: Case report

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  24. Metastasis to penis usually arises from genitourinary organs, but in rare cases, metastasis comes from the sigmoid colon. Furthermore, very few cases of penile metastasis of primary sigmoid colon carcinoma hav...

    Authors: Zhengbang Dong, Chao Qin, Qijie Zhang, Lei Zhang, Haijing Yang, Jingdong Zhang and Fei Wang

    Citation: BMC Urology 2015 15:20

    Content type: Case report

    Published on:

  25. The loss of a testicle to cancer involves much emotional impact to young males. Little is known about the number of patients with testicular germ cell tumour (GCT) who would accept a testicular prosthesis. Als...

    Authors: Klaus-Peter Dieckmann, Petra Anheuser, Stefan Schmidt, Benjamin Soyka-Hundt, Uwe Pichlmeier, Philipp Schriefer, Cord Matthies, Michael Hartmann and Christian G Ruf

    Citation: BMC Urology 2015 15:16

    Content type: Research article

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  26. More than 429,000 patients worldwide are diagnosed with bladder cancer each year and muscle-invasive bladder cancer has an especially poor outcome. The median age at diagnosis is over 70 years, and many patien...

    Authors: Vicente Guillem, Miguel Angel Climent, Javier Cassinello, Emilio Esteban, Daniel Castellano, José Luis González-Larriba, Pablo Maroto and Carlos Camps

    Citation: BMC Urology 2015 15:15

    Content type: Case report

    Published on:

  27. The human papillomavirus (HPV) prevalence in males has been reported to be between 3.6% and 84%, depending specially on the socioeconomic status. HPV infection has been related as a risk factor for penile canc...

    Authors: Isaura Danielli Borges de Sousa, Flávia Castello Branco Vidal, João Paulo Castello Branco Vidal, George Castro Figueira de Mello, Maria do Desterro Soares Brandão Nascimento and Luciane Maria Oliveira Brito

    Citation: BMC Urology 2015 15:13

    Content type: Research article

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  29. Adenocarcinoma of the urinary bladder is a rare malignancy. Radical surgery is suggested as the best available treatment for early-stage disease, but there is currently no consensus on standard chemotherapy re...

    Authors: Bin Yu, Jin Zhou, Hongzhou Cai, Ting Xu, Zicheng Xu, Qing Zou and Min Gu

    Citation: BMC Urology 2015 15:3

    Content type: Research article

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  30. Papillary renal cell carcinoma (pRCC) is a mixed group of tumors that constitutes about 15-20% of all renal cortical cancers. Strong enhancement on computerized tomography (CT) is a feature of clear cell, but ...

    Authors: Shaheen Alanee, Danuta I Dynda, Patrick Hemmer and Bradley Schwartz

    Citation: BMC Urology 2014 14:102

    Content type: Case report

    Published on:

  31. Partial nephrectomy has been underutilized in the United States. We investigated national trends in partial nephrectomy (PN) utilization before and after publication of the American Urological Association (AUA...

    Authors: Michael A Liss, Song Wang, Kerrin Palazzi, Ramzi Jabaji, Nishant Patel, Hak J Lee, J Kellogg Parsons and Ithaar H Derweesh

    Citation: BMC Urology 2014 14:101

    Content type: Research article

    Published on:

  32. To determine the relationship between renal cell carcinoma subtypes and the associated mortality and biochemical parameters. An additional aim was to analyze multiphasic multidetector computed tomography findi...

    Authors: Suat Keskin, Zeynep Keskin, Hakan Hakki Taskapu, Havva Kalkan, Mehmet Kaynar, Necdet Poyraz and Hatice Toy

    Citation: BMC Urology 2014 14:95

    Content type: Research article

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  33. Acanthosis nigricans is characterized by hyperpigmentation and hyperkeratosis of the skin or mucous membranes. Its malignant form is associated with internal neoplasms, especially gastric adenocarcinoma (55–61...

    Authors: Joanna Kubicka-Wołkowska, Sylwia Dębska-Szmich, Maja Lisik-Habib, Marcin Noweta and Piotr Potemski

    Citation: BMC Urology 2014 14:88

    Content type: Case report

    Published on:

  34. Cystic renal cell carcinoma (CRCC) is relatively rare; CRCC is frequently misdiagnosed as a benign renal cyst. CRCC carries an excellent prognosis following surgical treatment. The aim of our study was to summ...

    Authors: Shanwen Chen, Baiye Jin, Liqi Xu, Guanghou Fu, Hongzhou Meng, Ben Liu, Jun Li and Dan Xia

    Citation: BMC Urology 2014 14:87

    Content type: Research article

    Published on:

  35. The optimal timing of salvage androgen deprivation therapy (ADT) for biochemical recurrence after radical prostatectomy is controversial. We compared the outcomes of ultra-early versus early salvage ADT.

    Authors: Satoru Taguchi, Hiroshi Fukuhara, Takeshi Azuma, Motofumi Suzuki, Tetsuya Fujimura, Tohru Nakagawa, Akira Ishikawa, Haruki Kume, Yasuhiko Igawa and Yukio Homma

    Citation: BMC Urology 2014 14:81

    Content type: Research article

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  36. It is well recognized that the presence of positive surgical margins (PSM) after radical prostatectomy (RP) adversely affects cancer specific outcomes and recent evidence from randomized trials supports the us...

    Authors: Stepan Vesely, Ladislav Jarolim, Katerina Duskova, Marek Schmidt, Pavel Dusek and Marko Babjuk

    Citation: BMC Urology 2014 14:79

    Content type: Research article

    Published on:

  37. Renal angiomyolipomas (AMLs) are frequent in tuberous sclerosis and are responsible for a significant proportion of the morbidity in adulthood, mainly from bleeding complications, which are correlated to the s...

    Authors: Thierry Krummel, Julien Garnon, Hervé Lang, Afshin Gangi and Thierry Hannedouche

    Citation: BMC Urology 2014 14:77

    Content type: Case report

    Published on:

  38. Inflammation is a critical component of tumorigenesis, and many cancers arise from sites of infection, chronic irritation, and inflammation. Inflammatory cytokines triggered by tumors alter hematologic compone...

    Authors: Sally Temraz, Deborah Mukherji, Zein Al Abideen Farhat, Rami Nasr, Maya Charafeddine, Mohammed Shahait, Mohammad Rachad Wehbe, Rami Abou Ghaida, Ibrahim Abu Gheida and Ali Shamseddine

    Citation: BMC Urology 2014 14:76

    Content type: Research article

    Published on:

  39. Cardiac metastases from renal cell carcinoma without vena caval involvement are extremely rare with a limited number of cases reported in the worldwide literature until now. Nevertheless, this rare location of...

    Authors: Anna M Czarnecka, Pawel Sobczuk, Fei Lian and Cezary Szczylik

    Citation: BMC Urology 2014 14:73

    Content type: Case report

    Published on:

  40. The observed low metastatic potential and favorable survival of small incidentally detected renal cell carcinomas (RCCs) have been a part of the rationale for recommending partial nephrectomy as a first treatm...

    Authors: Johann P Ingimarsson, Martin I Sigurdsson, Sverrir Hardarson, Vigdis Petursdottir, Eirikur Jonsson, Gudmundur V Einarsson and Tomas Gudbjartsson

    Citation: BMC Urology 2014 14:72

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Urology 2015 15:5

  41. Inducing endoplasmic reticulum (ER) stress is a novel strategy used to treat malignancies. Inhibition of histone deacetylase (HDAC) 6 by the HDAC inhibitor panobinostat hinders the refolding of unfolded protei...

    Authors: Akinori Sato, Takako Asano, Makoto Isono, Keiichi Ito and Tomohiko Asano

    Citation: BMC Urology 2014 14:71

    Content type: Research article

    Published on:

  42. Bacillus Calmette-Guérin (BCG) is considered the most effective treatment to reduce recurrence and progression of non-muscle invasive bladder cancer (NMIBC) but can induce local side effects leading to treatme...

    Authors: Luca Topazio, Roberto Miano, Valentina Maurelli, Gabriele Gaziev, Mauro Gacci, Valerio Iacovelli and Enrico Finazzi-Agrò

    Citation: BMC Urology 2014 14:64

    Content type: Research article

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  43. Past attempts at detecting prostate cancer (PCa) cells in voided urine by traditional cytology have been impeded by undesirably low sensitivities but high specificities. To improve the sensitivities, we evalua...

    Authors: Yasushi Nakai, Satoshi Anai, Masaomi Kuwada, Makito Miyake, Yoshitomo Chihara, Nobumichi Tanaka, Akihide Hirayama, Katsunori Yoshida, Yoshihiko Hirao and Kiyohide Fujimoto

    Citation: BMC Urology 2014 14:59

    Content type: Research article

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  46. Gleason pattern 3 less often has molecular abnormalities and often behaves indolent. It is controversial whether low grade small foci of prostate cancer (PCa) on biopsy could avoid immediate treatment or not, ...

    Authors: Masahiro Yashi, Tomoya Mizuno, Hideo Yuki, Akinori Masuda, Tsunehito Kambara, Hironori Betsunoh, Hideyuki Abe, Yoshitatsu Fukabori, Osamu Muraishi, Koyu Suzuki, Yoshimasa Nakazato and Takao Kamai

    Citation: BMC Urology 2014 14:43

    Content type: Research article

    Published on:

  47. The survival benefits of adrenalectomy (ADx) in the setting of metastatic cancer and prognostic factors for recurrence-free (RFS) and overall survival (OS) after adrenalectomy for metastatic carcinoma are stil...

    Authors: Eu Chang Hwang, Insang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Suk Hee Heo, Jun Eul Hwang, Sung Gu Kang, Seok Ho Kang, Jeong Gu Lee, Je Jong Kim and Jun Cheon

    Citation: BMC Urology 2014 14:41

    Content type: Research article

    Published on:

  48. Seminomatous and non-seminomatous Germ Cell Tumors (GCT) of the testis are a rare cancer, with an estimated incidence of 56.3 per million white males and 10 per million black males in the United States.

    Authors: Pietro Rispoli, Paolo Destefanis, Paolo Garneri, Gianfranco Varetto, Beatrice Lillaz, Claudio Castagno, Patrizia Lista, Libero Ciuffreda and Dario Fontana

    Citation: BMC Urology 2014 14:40

    Content type: Case report

    Published on:

  49. Mucin-producing urothelial-type adenocarcinoma of the prostatic urethra is extremely rare. These lesions must be differentiated from other mucinous tumors including mucin-producing prostatic adenocarcinoma and...

    Authors: Elisabeth M Sebesta, Hossein S Mirheydar, J Kellogg Parsons, Jessica Wang-Rodriguez and A Karim Kader

    Citation: BMC Urology 2014 14:39

    Content type: Case report

    Published on:

  50. Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcino...

    Authors: Gustav Andersson, Christoffer Wennersten, Alexander Gaber, Karolina Boman, Björn Nodin, Mathias Uhlén, Ulrika Segersten, Per-Uno Malmström and Karin Jirström

    Citation: BMC Urology 2014 14:36

    Content type: Research article

    Published on:

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