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Urological oncology

This section considers clinical studies relevant to oncological disorders in urology

Page 5 of 6

  2. Gleason pattern 3 less often has molecular abnormalities and often behaves indolent. It is controversial whether low grade small foci of prostate cancer (PCa) on biopsy could avoid immediate treatment or not, ...

    Authors: Masahiro Yashi, Tomoya Mizuno, Hideo Yuki, Akinori Masuda, Tsunehito Kambara, Hironori Betsunoh, Hideyuki Abe, Yoshitatsu Fukabori, Osamu Muraishi, Koyu Suzuki, Yoshimasa Nakazato and Takao Kamai

    Citation: BMC Urology 2014 14:43

    Content type: Research article

    Published on:

  3. The survival benefits of adrenalectomy (ADx) in the setting of metastatic cancer and prognostic factors for recurrence-free (RFS) and overall survival (OS) after adrenalectomy for metastatic carcinoma are stil...

    Authors: Eu Chang Hwang, Insang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Suk Hee Heo, Jun Eul Hwang, Sung Gu Kang, Seok Ho Kang, Jeong Gu Lee, Je Jong Kim and Jun Cheon

    Citation: BMC Urology 2014 14:41

    Content type: Research article

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  4. Seminomatous and non-seminomatous Germ Cell Tumors (GCT) of the testis are a rare cancer, with an estimated incidence of 56.3 per million white males and 10 per million black males in the United States.

    Authors: Pietro Rispoli, Paolo Destefanis, Paolo Garneri, Gianfranco Varetto, Beatrice Lillaz, Claudio Castagno, Patrizia Lista, Libero Ciuffreda and Dario Fontana

    Citation: BMC Urology 2014 14:40

    Content type: Case report

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  5. Mucin-producing urothelial-type adenocarcinoma of the prostatic urethra is extremely rare. These lesions must be differentiated from other mucinous tumors including mucin-producing prostatic adenocarcinoma and...

    Authors: Elisabeth M Sebesta, Hossein S Mirheydar, J Kellogg Parsons, Jessica Wang-Rodriguez and A Karim Kader

    Citation: BMC Urology 2014 14:39

    Content type: Case report

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  6. Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcino...

    Authors: Gustav Andersson, Christoffer Wennersten, Alexander Gaber, Karolina Boman, Björn Nodin, Mathias Uhlén, Ulrika Segersten, Per-Uno Malmström and Karin Jirström

    Citation: BMC Urology 2014 14:36

    Content type: Research article

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  7. The prostatic anterior zone (AZ) is not targeted routinely by TRUS guided prostate biopsy (TRUS-Pbx). MRI is an accurate diagnostic tool for AZ tumors, but is often unavailable due to cost or system restrictio...

    Authors: Eric Cole, David Margel, Michael Greenspan, Bobby Shayegan, Edward Matsumoto, Marc A Fischer, Michael Patlas, Dean Daya and Jehonathan H Pinthus

    Citation: BMC Urology 2014 14:34

    Content type: Research article

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  8. Primary androgen deprivation therapy (PADT) is the most effective systemic therapy for patients with metastatic prostate cancer. Nevertheless, once PSA progression develops, the prognosis is serious and mortal...

    Authors: Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao and Kiyohide Fujimoto

    Citation: BMC Urology 2014 14:33

    Content type: Research article

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  9. Schwannomas are tumours arising from Schwann cells, which sheath the peripheral nerves. Here, we report a rare case of left intrascrotal, extratesticular schwannoma. Although rare, scrotal localisation of schw...

    Authors: Giovanni Palleschi, Antonio Carbone, Jessica Cacciotti, Giorgia Manfredonia, Natale Porta, Andrea Fuschi, Cosimo de Nunzio, Vincenzo Petrozza and Antonio Luigi Pastore

    Citation: BMC Urology 2014 14:32

    Content type: Case report

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  10. Castration-resistant prostate cancer (CRPC) patients have poor prognoses, and docetaxel (DTX) is among the few treatment options. An accurate risk classification to identify CRPC patient groups for which DTX w...

    Authors: Kazuhiko Nakano, Kenji Komatsu, Taro Kubo, Shinsuke Natsui, Akinori Nukui, Shinsuke Kurokawa, Minoru Kobayashi and Tatsuo Morita

    Citation: BMC Urology 2014 14:31

    Content type: Research article

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  11. Recently, three prospective randomized trials have shown that adjuvant radiotherapy (ART) after radical prostatectomy for the patients with pT3 and/or positive margins improves biochemical progression-free sur...

    Authors: Jung Hun Kang, Yun-Sok Ha, Sung Kim, Jihyeong Yu, Neal Patel, Jaspreet S Parihar, Amirali Hassanzadeh Salmasi, Wun-Jae Kim and Isaac Yi Kim

    Citation: BMC Urology 2014 14:30

    Content type: Research article

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  12. In patients with early prostate cancer, stratification by comorbidity could be of importance in clinical decision making as well as in characterizing patients enrolled into clinical trials. In this study, we i...

    Authors: Michael Froehner, Anna-Elisa Kellner, Rainer Koch, Gustavo B Baretton, Oliver W Hakenberg and Manfred P Wirth

    Citation: BMC Urology 2014 14:28

    Content type: Research article

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  13. Tyrosine kinase inhibitors (TKIs) have been used as standard therapy for patients with advanced renal cell carcinoma (RCC). However, information on factors predicting response to treatment with TKIs is lacking...

    Authors: Norihiko Tsuchiya, Takeshi Yuasa, Shinya Maita, Shintaro Narita, Takamitsu Inoue, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, Junji Yonese and Tomonori Habuchi

    Citation: BMC Urology 2014 14:26

    Content type: Research article

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  14. Oncologic and functional outcomes after radical prostatectomy (RP) can vary between surgeons to a greater extent than is expected by chance. We sought to examine the effects of surgeon variation on functional ...

    Authors: Sigrid Carlsson, Anders Berglund, Daniel Sjoberg, Ali Khatami, Johan Stranne, Svante Bergdahl, Pär Lodding, Gunnar Aus, Andrew Vickers and Jonas Hugosson

    Citation: BMC Urology 2014 14:25

    Content type: Research article

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  15. Few studies to date have directly compared outcomes of retropubic (RRP) and laparoscopic (LRP) radical prostatectomy. We investigated a single institution experience with RRP and LRP with respect to functional...

    Authors: Ahmed Magheli, Jonas Busch, Natalia Leva, Mark Schrader, Serdar Deger, Kurt Miller and Michael Lein

    Citation: BMC Urology 2014 14:18

    Content type: Research article

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  16. The HOX genes are a family of transcription factors that help to determine cell and tissue identity during early development, and which are also over-expressed in a number of malignancies where they have been sho...

    Authors: Richard Morgan, Angie Boxall, Kevin J Harrington, Guy R Simpson, Agnieszka Michael and Hardev S Pandha

    Citation: BMC Urology 2014 14:17

    Content type: Research article

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  17. An association between cigarette smoking and increased risk of clear cell renal cell carcinoma (ccRCC) has been established; however, there are limited data regarding the molecular mechanisms that underlie thi...

    Authors: Jeanette E Eckel-Passow, Daniel J Serie, Brian M Bot, Richard W Joseph, John C Cheville and Alexander S Parker

    Citation: BMC Urology 2014 14:14

    Content type: Research article

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  18. Radical prostatectomy is used to treat patients with clinically localized prostate cancer, but there have been few reports of its use in locally advanced disease. We evaluated the long-term results of radical ...

    Authors: Yuzuri Tsurumaki Sato, Hiroshi Fukuhara, Motofumi Suzuki, Tetsuya Fujimura, Tohru Nakagawa, Hiroaki Nishimatsu, Haruki Kume, Teppei Morikawa, Masashi Fukayama and Yukio Homma

    Citation: BMC Urology 2014 14:13

    Content type: Research article

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  19. CXCL12/CXCR4 transactivation of epidermal growth factor family receptors in lipid raft membrane microdomains on cell surface is thought to mediate tumor growth and subsequent development of metastatic disease....

    Authors: Donald Wong, Pridvi Kandagatla, Walter Korz and Sreenivasa R Chinni

    Citation: BMC Urology 2014 14:12

    Content type: Research article

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  20. BCG-RIVM strain was used in many treatment protocols for non-muscle invasive bladder cancer only as induction courses. Cho et al. (Anticancer Res 2012) compared BCG-RIVM induction and 'standard' maintenance (Lamm...

    Authors: Naim B Farah, Rami Ghanem and Mahmoud Amr

    Citation: BMC Urology 2014 14:11

    Content type: Research article

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  21. Prospective studies suggested an association between pioglitazone (Actos) use and the development of bladder cancer. Cancer pathology among pioglitazone users has not been characterized. We chose to compare th...

    Authors: Victoriano Romero, Charles Peyton, Ian Gray, Ashok Hemal and Ryan Terlecki

    Citation: BMC Urology 2014 14:10

    Content type: Research article

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  22. Prostate cancer is the most common cancer in older men in the United States (USA) and Western Europe. Androgen deprivation (AD) constitutes, in most cases, the first-line of treatment for these cases. The nega...

    Authors: Tobias Engel Ayer Botrel, Otávio Clark, Rodolfo Borges dos Reis, Antônio Carlos Lima Pompeo, Ubirajara Ferreira, Marcus Vinicius Sadi and Francisco Flávio Horta Bretas

    Citation: BMC Urology 2014 14:9

    Content type: Research article

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  23. We evaluated the clinical outcome of low grade Ta bladder cancer followed-up for a long period using the 2004 WHO grading system.

    Authors: Hiroaki Kobayashi, Eiji Kikuchi, Shuji Mikami, Takahiro Maeda, Nobuyuki Tanaka, Akira Miyajima, Ken Nakagawa and Mototsugu Oya

    Citation: BMC Urology 2014 14:5

    Content type: Research article

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  24. Although cystitis glandularis (CG) is a common benign urinary bladder epithelial abnormality, it remains unclear whether CG is a premalignant lesion. Cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) over...

    Authors: Zhongxing Li, Guangcheng Ge, Rui Feng, Dan Wu, Bin Shen, Xing Wang, Yan Cui, Junrong Li and Xiaobing Ju

    Citation: BMC Urology 2014 14:2

    Content type: Research article

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  25. Neoadjuvant chemotherapy has been shown to have benefit in T1 high-grade or T2 bladder cancer. However, neoadjuvant chemotherapy fails in some patients. Careful patient selection for neoadjuvant chemotherapy i...

    Authors: Shunichiro Nomura, Yasutomo Suzuki, Ryo Takahashi, Mika Terasaki, Ryoji Kimata, Tsutomu Hamasaki, Go Kimura, Akira Shimizu and Yukihiro Kondo

    Citation: BMC Urology 2013 13:73

    Content type: Research article

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  26. About 3 – 5% of all patients with testicular germ cell tumour (GCT) develop a contralateral cancer, the majority of which arise within 10–15 years. Little is known about the risk of second GCTs after more than...

    Authors: Klaus-Peter Dieckmann, Petra Anheuser, Florentine Sattler, Tobias Von Kügelgen, Cord Matthies and Christian Ruf

    Citation: BMC Urology 2013 13:71

    Content type: Case report

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  27. Nephrometric scoring systems aim to improve the manner in which tumoral complexity is measured and reported. Each system provides a way to objectively measure specific tumor features that influence technical f...

    Authors: Tarık Esen, Ömer Acar, Ahmet Musaoğlu and Metin Vural

    Citation: BMC Urology 2013 13:63

    Content type: Research article

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  28. The vaccine was efficiently effective against bladder cancer in earlier studies. However, a part of the mouse bladder tumour regrew due to regression after a period of time as the cancer stem cells could not b...

    Authors: Yong-tong Zhu, Cheng-yong Lei, Yang Luo, Na Liu, Cheng-wu He, Wei Chen, Fei Li, Yong-jian Deng and Wan-long Tan

    Citation: BMC Urology 2013 13:57

    Content type: Research article

    Published on:

  29. Uro-oncological neoplasms have both a high incidence and mortality rate and are therefore a major public health problem. The aim of this study was to evaluate research activity in uro-oncology over the last de...

    Authors: Frank Kunath, Steffen F Krause, Bernd Wullich, Peter J Goebell, Dirk G Engehausen, Maximilian Burger, Joerg J Meerpohl and Bastian Keck

    Citation: BMC Urology 2013 13:56

    Content type: Research article

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  30. The nodal status is a strong predictor for cancer specific death in patients with penile carcinoma, and the C-reactive protein (CRP) level at diagnosis has recently been shown to be associated with poor clinic...

    Authors: Andreas Al Ghazal, Sandra Steffens, Julie Steinestel, Rieke Lehmann, Thomas J Schnoeller, Anna Schulte-Hostede, Gerd Wegener, Florian Jentzmik, Mark Schrader, Markus A Kuczyk and Andres J Schrader

    Citation: BMC Urology 2013 13:53

    Content type: Research article

    Published on:

  31. Radiotherapy is an increasingly preferred treatment option for localized prostate cancer, and stereotactic body radiation therapy (SBRT) a relatively established modality of therapeutic irradiation. The presen...

    Authors: Giampaolo Bolzicco, Maria Silvia Favretto, Ninfa Satariano, Enrico Scremin, Carmelo Tambone and Andrea Tasca

    Citation: BMC Urology 2013 13:49

    Content type: Research article

    Published on:

  32. Management of renal cell carcinoma (RCC) with tumor thrombus extending to the renal vein and inferior vena cava (IVC) is challenging. The aim of this study was to evaluate the benefit of surgical management in...

    Authors: Shingo Hatakeyama, Takahiro Yoneyama, Itsuto Hamano, Hiromi Murasawa, Takuma Narita, Masaaki Oikawa, Kazuhisa Hagiwara, Daisuke Noro, Toshikazu Tanaka, Yoshimi Tanaka, Yasuhiro Hashimoto, Takuya Koie and Chikara Ohyama

    Citation: BMC Urology 2013 13:47

    Content type: Research article

    Published on:

  33. In this study, we further investigated the association of two biomarkers, CCL18 and A1AT, with bladder cancer (BCa) and evaluated the influence of potentially confounding factors in an experimental model.

    Authors: Makito Miyake, Shanti Ross, Adrienne Lawton, Myron Chang, Yunfeng Dai, Lourdes Mengual, Antonio Alcaraz, Evan Gomes Giacoia, Steve Goodison and Charles J Rosser

    Citation: BMC Urology 2013 13:42

    Content type: Research article

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  35. Imprinting is an important epigenetic regulator of gene expression that is often disrupted in cancer. While loss of imprinting (LOI) has been reported for two genes in prostate cancer (IGF2 and TFPI2), disease-re...

    Authors: Daniel I Jacobs, Yingying Mao, Alan Fu, William Kevin Kelly and Yong Zhu

    Citation: BMC Urology 2013 13:37

    Content type: Research article

    Published on:

  36. Villous adenoma arising in the urinary tract is rare tumor. Most cases have been identified as benign neoplasm in the colon. Villous adenoma of the gastrointestinal tract is thought arise from premalignant pol...

    Authors: Yoichiro Kato, Susumu Konari, Wataru Obara, Tamotsu Sugai and Tomoaki Fujioka

    Citation: BMC Urology 2013 13:36

    Content type: Case report

    Published on:

  38. To date, elective nephron-sparing surgery is an established method for the exstirpation of renal tumors. While open partial nephrectomy remains the reference standard of the management of renal masses, laparos...

    Authors: Hagen Loertzer, Arne Strauß, Rolf Herrmann Ringert and Philine Schneider

    Citation: BMC Urology 2013 13:31

    Content type: Research article

    Published on:

  39. Renal cell carcinoma (RCC) is a histopathologically and molecularly heterogeneous disease with the chromophobe subtype (chRCC) accounting for approximately 5% of all cases. The median overall survival of advan...

    Authors: Balaji Venugopal, Jawaher Ansari, Michael Aitchison, Lye Mun Tho, Roderick Campbell and Rob J Jones

    Citation: BMC Urology 2013 13:26

    Content type: Case report

    Published on:

  40. Matrix Metalloproteinases (MMPs) are key molecules for tumor growth, invasion and metastasis. Over-expression of different MMPs in tumor tissues can disturb the homeostasis and increase the level of various bo...

    Authors: Mohammed A Mohammed, Manar F Seleim, Mohga S Abdalla, Hayat M Sharada and Abdel Hady A Abdel Wahab

    Citation: BMC Urology 2013 13:25

    Content type: Research article

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  41. The management of patients with high-grade non muscle invasive bladder cancer (NMIBC) brings diagnostic and therapeutic challenges. In the current study, we sought to study the natural history of progression t...

    Authors: Guy Hidas, Dov Pode, Amos Shapiro, Ran Katz, Liat Appelbaum, Galina Pizov, Kevin C Zorn, Ezekiel H Landau, Mordechai Duvdevani and Ofer N Gofrit

    Citation: BMC Urology 2013 13:23

    Content type: Research article

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  42. Pheochromocytoma (paraganglioma) of the urinary bladder is a rare tumor. Herein we sought to review the contemporary literature on pheochromocytomas of the urinary bladder in order to further illustrate the pr...

    Authors: Jonathan A Beilan, Adrienne Lawton, Julio Hajdenberg and Charles J Rosser

    Citation: BMC Urology 2013 13:22

    Content type: Research article

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  44. Malignant transformation describes the phenomenon in which a somatic component of a germ cell teratoma undergoes malignant differentiation. A variety of different types of sarcoma and carcinoma, all non-germ c...

    Authors: Nina Zeh, Peter J Wild, Peter K Bode, Glen Kristiansen, Holger Moch, Tullio Sulser and Thomas Hermanns

    Citation: BMC Urology 2013 13:9

    Content type: Case report

    Published on:

  45. We sought to improve prostate cancer (PC) detection through developing a prostate biopsy clinical decision rule (PBCDR), based on an elevated PSA and laboratory biomarkers. This decision rule could be used aft...

    Authors: Owen T Hill, Thomas J Mason, Skai W Schwartz and Philip R Foulis

    Citation: BMC Urology 2013 13:6

    Content type: Research article

    Published on:

  46. Urinary bladder carcinoma stage T1 is an unpredictable disease that in some cases has a good prognosis with only local or no recurrence, but in others can appear as a more aggressive tumor with progression to ...

    Authors: Hans Olsson, Per Hultman, Johan Rosell, Peter Söderkvist and Staffan Jahnson

    Citation: BMC Urology 2013 13:5

    Content type: Research article

    Published on:

  47. Prostate cancer is the second most commonly diagnosed cancer in American men over the age of 45 years and is the third most common cause of cancer related deaths in American men. In 2012 it is estimated that 2...

    Authors: Diego A Palacios, Makito Miyake and Charles J Rosser

    Citation: BMC Urology 2013 13:4

    Content type: Review

    Published on:

  48. Papillary renal cell carcinoma is a rare cancer. Some cases can be attributed to individuals with hereditary renal cell carcinomas usually consisting of the clear cell subtype. In addition, two syndromes with ...

    Authors: Carl Ludwig Behnes, Christina Schlegel, Moneef Shoukier, Isabella Magiera, Frank Henschke, Alexander Schwarz, Felix Bremmer and Hagen Loertzer

    Citation: BMC Urology 2013 13:3

    Content type: Case report

    Published on:

  50. To clarify the significant clinicopathological and postdosimetric parameters to predict PSA bounce in patients who underwent low-dose-rate brachytherapy (LDR-brachytherapy) for prostate cancer.

    Authors: Nobumichi Tanaka, Isao Asakawa, Kiyohide Fujimoto, Satoshi Anai, Akihide Hirayama, Masatoshi Hasegawa, Noboru Konishi and Yoshihiko Hirao

    Citation: BMC Urology 2012 12:28

    Content type: Research article

    Published on:

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