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Voiding dysfunction

Section edited by Cosimo de Nunzio and Stephen Kraus

This section considers submissions relating to the management of urological male and female voiding dysfunction, including neurological disorders and prostatic diseases. (NOTE: Articles dealing with the diagnosis or treatment of prostate cancer should be submitted to the "Urological oncology" section)

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  1. The prevalence of overactive bladder syndrome (OAB) increases with age. Sleep disturbances in elderly individuals with OAB is a common problem. The purpose of this study was to examine the effects of a biofeed...

    Authors: Jooyeon Park, Choal Hee Park, Sang-Eun Jun, Eun-Ju Lee, Seung Wan Kang and Nahyun Kim

    Citation: BMC Urology 2019 19:109

    Content type: Research article

    Published on:

  2. Interstitial Cystitis (IC) is a debilitating disorder of the bladder, with a multifactorial and poorly understood origin dealing with microcirculation repeated damages. Also Fibromyalgia (FM) is a persistent d...

    Authors: Gerardo Bosco, Edoardo Ostardo, Alex Rizzato, Giacomo Garetto, Matteo Paganini, Giorgio Melloni, Giampiero Giron, Lodovico Pietrosanti, Ivo Martinelli and Enrico Camporesi

    Citation: BMC Urology 2019 19:108

    Content type: Research article

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  3. Competent detrusor muscles with coordinated contraction and relaxation are crucial for normal urinary bladder storage and emptying functions. Hence, detrusor instability, and subsequently bladder overactivity,...

    Authors: Dalia F. El Agamy and Yahya M. Naguib

    Citation: BMC Urology 2019 19:103

    Content type: Research article

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  4. Neuroendocrine (NE) cells may have an impact on the development and initial growth of benign prostatic hyperplasia (BPH) according to previous human studies.

    Authors: Yuki Kyoda, Koji Ichihara, Kohei Hashimoto, Ko Kobayashi, Fumimasa Fukuta and Naoya Masumori

    Citation: BMC Urology 2019 19:91

    Content type: Research article

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  5. Lower urinary tract symptoms (LUTS) is the most common complication of diabetes. However, the underlying pathogenesis of cultured negative LUTS (cn-LUTS) in diabetic patients has not been well understood. Nume...

    Authors: Jiawei Chen, Jie Zhao, Ying Cao, Guihao Zhang, Yang Chen, Jialei Zhong, Weina Huang, Jiarong Zeng and Peng Wu

    Citation: BMC Urology 2019 19:78

    Content type: Research article

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  6. Porcine urinary bladders are widely used for uro-pharmacological examinations due to their resemblance to the human organ. However, characterisations of the porcine urothelium at the molecular level are scarce...

    Authors: Dorothea Leonhäuser, Jasmin Kranz, Regina Leidolf, Patrick Arndt, Ulrich Schwantes, Joachim Geyer and Joachim O. Grosse

    Citation: BMC Urology 2019 19:62

    Content type: Research article

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  7. Interstitial cystitis/bladder pain syndrome (IC/BPS) and female sexual dysfunction (FSD) are common conditions that substantially reduce women’s health. In particular, women with IC/BPS show vulvodynia, a kind...

    Authors: Su Jin Kim, Jayoung Kim and Hana Yoon

    Citation: BMC Urology 2019 19:47

    Content type: Review

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  8. The prevalence of pure stress urinary incontinence (P-SUI) and the role of urodynamic investigation (UDI) prior to surgery for stress urinary incontinence (SUI) is debated. Since the exact prevalence of P-SUI ...

    Authors: Emanuele Rubilotta, Matteo Balzarro, Antonio D’Amico, Maria Angela Cerruto, Silvia Bassi, Chiara Bovo, Valerio Iacovelli, Daniele Bianchi, Walter Artibani and Enrico Finazzi Agrò

    Citation: BMC Urology 2019 19:44

    Content type: Research article

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  9. Previously published results from our laboratory identified a mechano-gated two-pore domain potassium channel, TREK-1, as a main mechanosensor in the smooth muscle of the human urinary bladder. One of the limi...

    Authors: Ricardo H. Pineda, Joseph Hypolite, Sanghee Lee, Alonso Carrasco Jr, Nao Iguchi, Randall B. Meacham and Anna P. Malykhina

    Citation: BMC Urology 2019 19:40

    Content type: Research article

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  10. Post-radical prostatectomy urinary incontinence (PPI) negatively affects the quality of life of patients. Accurate identification of the problem by physicians is essential for adequate postoperative management...

    Authors: Rafael Castilho Borges, Marcos Tobias-Machado, Estefânia Nicoleti Gabriotti, Francisco Winter dos Santos Figueiredo, Carlos Alberto Bezerra and Sidney Glina

    Citation: BMC Urology 2019 19:32

    Content type: Research article

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  11. We performed a meta-analysis to confirm the efficacy and safety of the combination of tamsulosin plus dutasteride compared with tamsulosin monotherapy in treating benign prostatic hyperplasia (BPH) during a tr...

    Authors: Zhongbao Zhou, Yuanshan Cui, Jitao Wu, Rui Ding, Tong Cai and Zhenli Gao

    Citation: BMC Urology 2019 19:17

    Content type: Research article

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  12. Overactive bladder (OAB) can frequently exert a negative effect on female sexual function. Mirabegron, a β3 receptor agonist, improves OAB symptoms, but there are very few information about its role on female ...

    Authors: Marilena Gubbiotti, Antonella Giannantoni, Simona Cantaluppi, Anna Chiara Coluccia, Fabio Ghezzi and Maurizio Serati

    Citation: BMC Urology 2019 19:7

    Content type: Research article

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  13. To study nocturia in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) after medical or placebo treatment.

    Authors: Zhigang Xue, Yunhua Lin, Yongguang Jiang, Nengbao Wei and Jinwen Bi

    Citation: BMC Urology 2018 18:115

    Content type: Research article

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  14. Elderly people are representative for the patients most likely to be treated with anticholinergics for overactive bladder (OAB). They often receive further drugs with anticholinergic properties for concomitant...

    Authors: A. Ivchenko, R.-H. Bödeker, C. Neumeister and A. Wiedemann

    Citation: BMC Urology 2018 18:80

    Content type: Research article

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  15. Neurogenic bladder (NGB) dysfunction after spinal cord injury (SCI) is generally irreversible. Preliminary animal and human studies have suggested that initiation of sacral neuromodulation (SNM) immediately fo...

    Authors: Jeffrey D. Redshaw, Sara M. Lenherr, Sean P. Elliott, John T. Stoffel, Jeffrey P. Rosenbluth, Angela P. Presson and Jeremy B. Myers

    Citation: BMC Urology 2018 18:72

    Content type: Study protocol

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  16. This study aims to explore the feasibility of anchoring a four-arm transvaginal mesh (TVM) to the mid-urethra to correct an anterior compartment POP–Quantification stage II–III (Q II–III) and concomitant genuine ...

    Authors: Zoltán Fekete, Szilvia Kőrösi, László Pajor, Zoltán Bajory, Gábor Németh and Zoltan Kozinszky

    Citation: BMC Urology 2018 18:53

    Content type: Research article

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  17. Although the pelvic autonomic plexus branches are considered to be a mixture of sympathetic and parasympathetic nerves, little is known regarding the composite fibers of the pelvic plexus branches. This study ...

    Authors: Kuniyasu Muraoka, Shuichi Morizane, Keisuke Hieda, Masashi Honda, Takehiro Sejima, Gen Murakami, Shin-ichi Abe and Atsushi Takenaka

    Citation: BMC Urology 2018 18:47

    Content type: Research article

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  18. Adjustable single-incision mini-sling (SIMS) is a new category of SIMS for stress urinary incontinence (SUI). The aim of this study was to compare the efficacy and safety of adjustable single-incision mini-sli...

    Authors: Fuding Bai, Jimin Chen, Zhewei Zhang, Yichun Zheng, Jiaming Wen, Xiawa Mao and Nan Zhang

    Citation: BMC Urology 2018 18:44

    Content type: Research article

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  19. Lower ureteric stones and lower urinary tract symptoms are common in urology.Drug treatment is one of standard therapy,but the efficacy was controversial.Thus we aimed to investigate the efficacy and safety of...

    Authors: Xifeng Sun, Wei Guan, Haoran Liu, Kun Tang, Libin Yan, Yangjun Zhang, Jin Zeng, Zhiqiang Chen, Hua Xu and Zhangqun Ye

    Citation: BMC Urology 2018 18:30

    Content type: Research article

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  20. Bladder outlet obstruction is a common urological condition. We aimed to summarize available evidences about bladder outlet obstruction-induced molecular and morphological alterations occurring in human bladder.

    Authors: Ferdinando Fusco, Massimiliano Creta, Cosimo De Nunzio, Valerio Iacovelli, Francesco Mangiapia, Vincenzo Li Marzi and Enrico Finazzi Agrò

    Citation: BMC Urology 2018 18:15

    Content type: Research article

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  21. To preliminary investigate the effects of silodosin 8 mg once daily on obstruction urodynamic parameters and subjective symptoms in Caucasian patients with lower urinary tract symptoms suggestive of benign pro...

    Authors: Ferdinando Fusco, Massimiliano Creta, Nicola Longo, Francesco Persico, Marco Franco and Vincenzo Mirone

    Citation: BMC Urology 2018 18:12

    Content type: Research article

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  22. As a potential new treatment for overactive bladder (OAB), we investigated the feasibility of non-invasively activating multiple nerve targets in the lower leg.

    Authors: Eshani Sharan, Kelly Hunter, Magdy Hassouna and Paul B. Yoo

    Citation: BMC Urology 2018 18:10

    Content type: Research article

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  23. To investigate the efficacy of tamsulosin in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE) with intravesical prostatic protrusion (IPP). Ultrasound measurement of the...

    Authors: L. Topazio, C. Perugia, C. De Nunzio, G. Gaziev, V. Iacovelli, D. Bianchi, G. Vespasiani and E. Finazzi Agrò

    Citation: BMC Urology 2018 18:6

    Content type: Research article

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  24. This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats.

    Authors: Sung Dae Kim, Kang Jun Cho and Joon Chul Kim

    Citation: BMC Urology 2017 17:121

    Content type: Research article

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  25. To evaluate the effects of combined bladder neck preservation and posterior reconstruction techniques on early and long term urinary continence in patients treated by robotic assisted radical prostatectomy (RA...

    Authors: Riccardo Bartoletti, Andrea Mogorovich, Francesco Francesca, Giorgio Pomara and Cesare Selli

    Citation: BMC Urology 2017 17:119

    Content type: Research article

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  26. Lower urinary tract symptoms (LUTS) and overactive bladder (OAB) symptoms have a substantial effect on quality of life (QoL). We report QoL and mental health results from a LUTS prevalence study in three Asian...

    Authors: Kyu-Sung Lee, Tag Keun Yoo, Limin Liao, Jianye Wang, Yao-Chi Chuang, Shih-Ping Liu, Romeo Chu and Budiwan Sumarsono

    Citation: BMC Urology 2017 17:108

    Content type: Research article

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  27. The majority of spinal cord injury (SCI) patients have urinary issues, such as incontinence, retention, and frequency. These problems place a significant burden on patients’ physical health and quality of life...

    Authors: Darshan P. Patel, Sara M. Lenherr, John T. Stoffel, Sean P. Elliott, Blayne Welk, Angela P. Presson, Amitabh Jha, Jeffrey Rosenbluth and Jeremy B. Myers

    Citation: BMC Urology 2017 17:95

    Content type: Study protocol

    Published on:

  28. Urinary tract infections (UTI) are among the most prevalent microbial diseases and their financial burden on society is substantial. The continuing increase of antibiotic resistance worldwide is alarming. Thus...

    Authors: Lorenz Leitner, Wilbert Sybesma, Nina Chanishvili, Marina Goderdzishvili, Archil Chkhotua, Aleksandre Ujmajuridze, Marc P. Schneider, Andrea Sartori, Ulrich Mehnert, Lucas M. Bachmann and Thomas M. Kessler

    Citation: BMC Urology 2017 17:90

    Content type: Study protocol

    Published on:

  29. Male stress urinary incontinence is a prevalent condition after radical prostatectomy. While the standard recommendation for the management of urine leakage is pelvic floor muscle training, its efficacy is sti...

    Authors: Shinobu Shimizu, Tokunori Yamamoto, Shinobu Nakayama, Akihiro Hirakawa, Yachiyo Kuwatsuka, Yasuhito Funahashi, Yoshihisa Matsukawa, Keisuke Takanari, Kazuhiro Toriyama, Yuzuru Kamei, Kazutaka Narimoto, Tomonori Yamanishi, Osamu Ishizuka, Masaaki Mizuno and Momokazu Gotoh

    Citation: BMC Urology 2017 17:89

    Content type: Study protocol

    Published on:

  30. Patients with diabetes experience lower urinary tract symptoms. Cystopathy may evolve into underactive bladder (UAB), depending on the degree and duration of the symptoms. In the present study, we aimed to inv...

    Authors: Saori Yonekubo, Satoshi Tatemichi, Kazuyasu Maruyama and Mamoru Kobayashi

    Citation: BMC Urology 2017 17:64

    Content type: Research article

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  31. There are three minimally invasive methods for the management of large upper impacted ureteral stones: mini-percutaneous nephrolithotomy (MPCNL), transurethral ureteroscope lithotripsy (URSL), and retroperiton...

    Authors: Yunyan Wang, Bing Zhong, Xiaosong Yang, Gongcheng Wang, Peijin Hou and Junsong Meng

    Citation: BMC Urology 2017 17:50

    Content type: Research article

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  32. Overactive bladder is more prevalent in patients with type 2 diabetes than in those without diabetes. Unhealthy toileting behaviors may be associated with the development and worsening of overactive bladder sy...

    Authors: Dongjuan Xu, Ran Cheng, Aixia Ma, Meng Zhao and Kefang Wang

    Citation: BMC Urology 2017 17:42

    Content type: Research article

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  33. To assess treatment persistence and adherence in men ≥45 years of age with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), using prescription records from the Netherland...

    Authors: Marcus J. Drake, Sally Bowditch, Emilio Arbe, Zalmai Hakimi, Florent Guelfucci, Ikbel Amri and Jameel Nazir

    Citation: BMC Urology 2017 17:36

    Content type: Research article

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  34. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is still a challenge to manage for all physicians. We feel that a summary of the current literature and a systematic review to evaluate the therapeuti...

    Authors: Tommaso Cai, Paolo Verze, Roberto La Rocca, Umberto Anceschi, Cosimo De Nunzio and Vincenzo Mirone

    Citation: BMC Urology 2017 17:32

    Content type: Research article

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  35. Several studies have shown that the antimuscarinic treatment of overactive bladder is characterized by low long-term persistence rates. We have investigated the persistence of solifenacin in real life by means...

    Authors: Marloes J. Tijnagel, Jeroen R. Scheepe and Bertil F. M. Blok

    Citation: BMC Urology 2017 17:30

    Content type: Research article

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  36. In last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in...

    Authors: Mauro Gacci, Arcangelo Sebastianelli, Matteo Salvi, Cosimo De Nunzio, Linda Vignozzi, Giovanni Corona, Tommaso Jaeger, Tommaso Chini, Giorgio Ivan Russo, Mario Maggi, Giuseppe Morgia, Andrea Tubaro, Marco Carini and Sergio Serni

    Citation: BMC Urology 2017 17:22

    Content type: Research article

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  37. Intermittent catheterisation is the method of choice for the management of bladder dysfunctions. Different urinary catheters are available, but there is conflicting evidence on which type of catheter is best. ...

    Authors: Carla Rognoni and Rosanna Tarricone

    Citation: BMC Urology 2017 17:4

    Content type: Research article

    Published on:

  38. This study was designed to evaluate the efficacy and safety of fulranumab, a fully human monoclonal antibody directed against nerve growth factor (NGF), for pain relief in patients with interstitial cystitis/b...

    Authors: Hao Wang, Lucille J. Russell, Kathleen M. Kelly, Steven Wang and John Thipphawong

    Citation: BMC Urology 2017 17:2

    Content type: Research article

    Published on:

  39. Lower urinary tract symptoms are highly prevalent and a large proportion of these symptoms are known to be associated with a dysfunction of the afferent pathways. Diagnostic tools for an objective and reproduc...

    Authors: Stéphanie van der Lely, Martina Stefanovic, Melanie R. Schmidhalter, Marta Pittavino, Reinhard Furrer, Martina D. Liechti, Martin Schubert, Thomas M. Kessler and Ulrich Mehnert

    Citation: BMC Urology 2016 16:69

    Content type: Study protocol

    Published on:

  40. Lower Urinary Tract Symptoms (LUTS) in men are a common clinical problem in urology and have been historically strictly linked to benign prostatic hyperplasia (BPH), which may lead to bladder outlet obstructio...

    Authors: Simone Albisinni, Ibrahim Biaou, Quentin Marcelis, Fouad Aoun, Cosimo De Nunzio and Thierry Roumeguère

    Citation: BMC Urology 2016 16:58

    Content type: Research article

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  41. To assess the efficacy and safety of intradetrusor onabotulinumtoxinA (OnabotA) injection treatment in patients with neurogenic lower urinary tract dysfunction (NLUTD), especially for patients with Parkinson d...

    Authors: Stephanie C. Knüpfer, Susanne A. Schneider, Mareike M. Averhoff, Carsten M. Naumann, Günther Deuschl, Klaus-Peter Jünemann and Moritz F. Hamann

    Citation: BMC Urology 2016 16:55

    Content type: Research article

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  42. To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT) as monotherapy or combined with tolterodine in women with overactive bladder (OAB).

    Authors: Dong-dong Xiao, Jian-wei Lv, Xin Xie, Xing-wei Jin, Mu-jun Lu and Yuan Shao

    Citation: BMC Urology 2016 16:49

    Content type: Research article

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  43. Mirabegron is a β3-adrenoreceptor agonist developed for treatment of overactive bladder (OAB). α1-Adrenergic receptor blockers are effective for lower urinary tract symptoms (LUTS) in male patients. However, t...

    Authors: Tomohiro Matsuo, Yasuyoshi Miyata, Katsura Kakoki, Miki Yuzuriha, Akihiro Asai, Kojiro Ohba and Hideki Sakai

    Citation: BMC Urology 2016 16:45

    Content type: Research article

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  44. The activation of TRPA1 channel is implicated in hyper-reflexic micturition similar to overactive bladder. In this study, we aimed to investigate the effects of blocking TRPA1 via intrathecal administration of...

    Authors: Zhipeng Chen, Shuqi Du, Chuize Kong, Zhe Zhang and Al-dhabi Mokhtar

    Citation: BMC Urology 2016 16:33

    Content type: Research article

    Published on:

  • BMC Urology works with with Cochrane Urology in providing our authors with expert advice on systematic reviews and meta-analyses

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