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Voiding dysfunction

Section edited by Cosimo de Nunzio and Stephen Kraus

This section considers submissions relating to the management of urological male and female voiding dysfunction, including neurological disorders and prostatic diseases. (NOTE: Articles dealing with the diagnosis or treatment of prostate cancer should be submitted to the "Urological oncology" section)

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  1. Content type: Research article

    Elderly people are representative for the patients most likely to be treated with anticholinergics for overactive bladder (OAB). They often receive further drugs with anticholinergic properties for concomitant...

    Authors: A. Ivchenko, R.-H. Bödeker, C. Neumeister and A. Wiedemann

    Citation: BMC Urology 2018 18:80

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  2. Content type: Study protocol

    Neurogenic bladder (NGB) dysfunction after spinal cord injury (SCI) is generally irreversible. Preliminary animal and human studies have suggested that initiation of sacral neuromodulation (SNM) immediately fo...

    Authors: Jeffrey D. Redshaw, Sara M. Lenherr, Sean P. Elliott, John T. Stoffel, Jeffrey P. Rosenbluth, Angela P. Presson and Jeremy B. Myers

    Citation: BMC Urology 2018 18:72

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  3. Content type: Research article

    This study aims to explore the feasibility of anchoring a four-arm transvaginal mesh (TVM) to the mid-urethra to correct an anterior compartment POP–Quantification stage II–III (Q II–III) and concomitant genuine ...

    Authors: Zoltán Fekete, Szilvia Kőrösi, László Pajor, Zoltán Bajory, Gábor Németh and Zoltan Kozinszky

    Citation: BMC Urology 2018 18:53

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  4. Content type: Research article

    Although the pelvic autonomic plexus branches are considered to be a mixture of sympathetic and parasympathetic nerves, little is known regarding the composite fibers of the pelvic plexus branches. This study ...

    Authors: Kuniyasu Muraoka, Shuichi Morizane, Keisuke Hieda, Masashi Honda, Takehiro Sejima, Gen Murakami, Shin-ichi Abe and Atsushi Takenaka

    Citation: BMC Urology 2018 18:47

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  5. Content type: Research article

    Adjustable single-incision mini-sling (SIMS) is a new category of SIMS for stress urinary incontinence (SUI). The aim of this study was to compare the efficacy and safety of adjustable single-incision mini-sli...

    Authors: Fuding Bai, Jimin Chen, Zhewei Zhang, Yichun Zheng, Jiaming Wen, Xiawa Mao and Nan Zhang

    Citation: BMC Urology 2018 18:44

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  6. Content type: Research article

    Lower ureteric stones and lower urinary tract symptoms are common in urology.Drug treatment is one of standard therapy,but the efficacy was controversial.Thus we aimed to investigate the efficacy and safety of...

    Authors: Xifeng Sun, Wei Guan, Haoran Liu, Kun Tang, Libin Yan, Yangjun Zhang, Jin Zeng, Zhiqiang Chen, Hua Xu and Zhangqun Ye

    Citation: BMC Urology 2018 18:30

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  7. Content type: Research article

    Bladder outlet obstruction is a common urological condition. We aimed to summarize available evidences about bladder outlet obstruction-induced molecular and morphological alterations occurring in human bladder.

    Authors: Ferdinando Fusco, Massimiliano Creta, Cosimo De Nunzio, Valerio Iacovelli, Francesco Mangiapia, Vincenzo Li Marzi and Enrico Finazzi Agrò

    Citation: BMC Urology 2018 18:15

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  8. Content type: Research article

    To preliminary investigate the effects of silodosin 8 mg once daily on obstruction urodynamic parameters and subjective symptoms in Caucasian patients with lower urinary tract symptoms suggestive of benign pro...

    Authors: Ferdinando Fusco, Massimiliano Creta, Nicola Longo, Francesco Persico, Marco Franco and Vincenzo Mirone

    Citation: BMC Urology 2018 18:12

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  9. Content type: Research article

    As a potential new treatment for overactive bladder (OAB), we investigated the feasibility of non-invasively activating multiple nerve targets in the lower leg.

    Authors: Eshani Sharan, Kelly Hunter, Magdy Hassouna and Paul B. Yoo

    Citation: BMC Urology 2018 18:10

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  10. Content type: Research article

    To investigate the efficacy of tamsulosin in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE) with intravesical prostatic protrusion (IPP). Ultrasound measurement of the...

    Authors: L. Topazio, C. Perugia, C. De Nunzio, G. Gaziev, V. Iacovelli, D. Bianchi, G. Vespasiani and E. Finazzi Agrò

    Citation: BMC Urology 2018 18:6

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  11. Content type: Research article

    This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats.

    Authors: Sung Dae Kim, Kang Jun Cho and Joon Chul Kim

    Citation: BMC Urology 2017 17:121

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  12. Content type: Research article

    To evaluate the effects of combined bladder neck preservation and posterior reconstruction techniques on early and long term urinary continence in patients treated by robotic assisted radical prostatectomy (RA...

    Authors: Riccardo Bartoletti, Andrea Mogorovich, Francesco Francesca, Giorgio Pomara and Cesare Selli

    Citation: BMC Urology 2017 17:119

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  13. Content type: Research article

    Lower urinary tract symptoms (LUTS) and overactive bladder (OAB) symptoms have a substantial effect on quality of life (QoL). We report QoL and mental health results from a LUTS prevalence study in three Asian...

    Authors: Kyu-Sung Lee, Tag Keun Yoo, Limin Liao, Jianye Wang, Yao-Chi Chuang, Shih-Ping Liu, Romeo Chu and Budiwan Sumarsono

    Citation: BMC Urology 2017 17:108

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  14. Content type: Study protocol

    The majority of spinal cord injury (SCI) patients have urinary issues, such as incontinence, retention, and frequency. These problems place a significant burden on patients’ physical health and quality of life...

    Authors: Darshan P. Patel, Sara M. Lenherr, John T. Stoffel, Sean P. Elliott, Blayne Welk, Angela P. Presson, Amitabh Jha, Jeffrey Rosenbluth and Jeremy B. Myers

    Citation: BMC Urology 2017 17:95

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  15. Content type: Study protocol

    Urinary tract infections (UTI) are among the most prevalent microbial diseases and their financial burden on society is substantial. The continuing increase of antibiotic resistance worldwide is alarming. Thus...

    Authors: Lorenz Leitner, Wilbert Sybesma, Nina Chanishvili, Marina Goderdzishvili, Archil Chkhotua, Aleksandre Ujmajuridze, Marc P. Schneider, Andrea Sartori, Ulrich Mehnert, Lucas M. Bachmann and Thomas M. Kessler

    Citation: BMC Urology 2017 17:90

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  16. Content type: Study protocol

    Male stress urinary incontinence is a prevalent condition after radical prostatectomy. While the standard recommendation for the management of urine leakage is pelvic floor muscle training, its efficacy is sti...

    Authors: Shinobu Shimizu, Tokunori Yamamoto, Shinobu Nakayama, Akihiro Hirakawa, Yachiyo Kuwatsuka, Yasuhito Funahashi, Yoshihisa Matsukawa, Keisuke Takanari, Kazuhiro Toriyama, Yuzuru Kamei, Kazutaka Narimoto, Tomonori Yamanishi, Osamu Ishizuka, Masaaki Mizuno and Momokazu Gotoh

    Citation: BMC Urology 2017 17:89

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  17. Content type: Research article

    Patients with diabetes experience lower urinary tract symptoms. Cystopathy may evolve into underactive bladder (UAB), depending on the degree and duration of the symptoms. In the present study, we aimed to inv...

    Authors: Saori Yonekubo, Satoshi Tatemichi, Kazuyasu Maruyama and Mamoru Kobayashi

    Citation: BMC Urology 2017 17:64

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  18. Content type: Research article

    There are three minimally invasive methods for the management of large upper impacted ureteral stones: mini-percutaneous nephrolithotomy (MPCNL), transurethral ureteroscope lithotripsy (URSL), and retroperiton...

    Authors: Yunyan Wang, Bing Zhong, Xiaosong Yang, Gongcheng Wang, Peijin Hou and Junsong Meng

    Citation: BMC Urology 2017 17:50

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  19. Content type: Research article

    Overactive bladder is more prevalent in patients with type 2 diabetes than in those without diabetes. Unhealthy toileting behaviors may be associated with the development and worsening of overactive bladder sy...

    Authors: Dongjuan Xu, Ran Cheng, Aixia Ma, Meng Zhao and Kefang Wang

    Citation: BMC Urology 2017 17:42

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  20. Content type: Research article

    To assess treatment persistence and adherence in men ≥45 years of age with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), using prescription records from the Netherland...

    Authors: Marcus J. Drake, Sally Bowditch, Emilio Arbe, Zalmai Hakimi, Florent Guelfucci, Ikbel Amri and Jameel Nazir

    Citation: BMC Urology 2017 17:36

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  21. Content type: Research article

    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is still a challenge to manage for all physicians. We feel that a summary of the current literature and a systematic review to evaluate the therapeuti...

    Authors: Tommaso Cai, Paolo Verze, Roberto La Rocca, Umberto Anceschi, Cosimo De Nunzio and Vincenzo Mirone

    Citation: BMC Urology 2017 17:32

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  22. Content type: Research article

    Several studies have shown that the antimuscarinic treatment of overactive bladder is characterized by low long-term persistence rates. We have investigated the persistence of solifenacin in real life by means...

    Authors: Marloes J. Tijnagel, Jeroen R. Scheepe and Bertil F. M. Blok

    Citation: BMC Urology 2017 17:30

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  23. Content type: Research article

    In last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in...

    Authors: Mauro Gacci, Arcangelo Sebastianelli, Matteo Salvi, Cosimo De Nunzio, Linda Vignozzi, Giovanni Corona, Tommaso Jaeger, Tommaso Chini, Giorgio Ivan Russo, Mario Maggi, Giuseppe Morgia, Andrea Tubaro, Marco Carini and Sergio Serni

    Citation: BMC Urology 2017 17:22

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  24. Content type: Research article

    Intermittent catheterisation is the method of choice for the management of bladder dysfunctions. Different urinary catheters are available, but there is conflicting evidence on which type of catheter is best. ...

    Authors: Carla Rognoni and Rosanna Tarricone

    Citation: BMC Urology 2017 17:4

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  25. Content type: Research article

    This study was designed to evaluate the efficacy and safety of fulranumab, a fully human monoclonal antibody directed against nerve growth factor (NGF), for pain relief in patients with interstitial cystitis/b...

    Authors: Hao Wang, Lucille J. Russell, Kathleen M. Kelly, Steven Wang and John Thipphawong

    Citation: BMC Urology 2017 17:2

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  26. Content type: Study protocol

    Lower urinary tract symptoms are highly prevalent and a large proportion of these symptoms are known to be associated with a dysfunction of the afferent pathways. Diagnostic tools for an objective and reproduc...

    Authors: Stéphanie van der Lely, Martina Stefanovic, Melanie R. Schmidhalter, Marta Pittavino, Reinhard Furrer, Martina D. Liechti, Martin Schubert, Thomas M. Kessler and Ulrich Mehnert

    Citation: BMC Urology 2016 16:69

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  27. Content type: Research article

    Lower Urinary Tract Symptoms (LUTS) in men are a common clinical problem in urology and have been historically strictly linked to benign prostatic hyperplasia (BPH), which may lead to bladder outlet obstructio...

    Authors: Simone Albisinni, Ibrahim Biaou, Quentin Marcelis, Fouad Aoun, Cosimo De Nunzio and Thierry Roumeguère

    Citation: BMC Urology 2016 16:58

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  28. Content type: Research article

    To assess the efficacy and safety of intradetrusor onabotulinumtoxinA (OnabotA) injection treatment in patients with neurogenic lower urinary tract dysfunction (NLUTD), especially for patients with Parkinson d...

    Authors: Stephanie C. Knüpfer, Susanne A. Schneider, Mareike M. Averhoff, Carsten M. Naumann, Günther Deuschl, Klaus-Peter Jünemann and Moritz F. Hamann

    Citation: BMC Urology 2016 16:55

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  29. Content type: Research article

    To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT) as monotherapy or combined with tolterodine in women with overactive bladder (OAB).

    Authors: Dong-dong Xiao, Jian-wei Lv, Xin Xie, Xing-wei Jin, Mu-jun Lu and Yuan Shao

    Citation: BMC Urology 2016 16:49

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  30. Content type: Research article

    Mirabegron is a β3-adrenoreceptor agonist developed for treatment of overactive bladder (OAB). α1-Adrenergic receptor blockers are effective for lower urinary tract symptoms (LUTS) in male patients. However, t...

    Authors: Tomohiro Matsuo, Yasuyoshi Miyata, Katsura Kakoki, Miki Yuzuriha, Akihiro Asai, Kojiro Ohba and Hideki Sakai

    Citation: BMC Urology 2016 16:45

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  31. Content type: Research article

    The activation of TRPA1 channel is implicated in hyper-reflexic micturition similar to overactive bladder. In this study, we aimed to investigate the effects of blocking TRPA1 via intrathecal administration of...

    Authors: Zhipeng Chen, Shuqi Du, Chuize Kong, Zhe Zhang and Al-dhabi Mokhtar

    Citation: BMC Urology 2016 16:33

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  32. Content type: Research article

    Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90–95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can...

    Authors: Giorgio Bozzini, Marco Provenzano, Nicolò Buffi, Mauro Seveso, Giovanni Lughezzani, Giorgio Guazzoni, Alberto Mandressi and Gianluigi Taverna

    Citation: BMC Urology 2016 16:25

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  33. Content type: Study protocol

    Urinary tract infections [UTIs] are very common in people with Spinal Cord Injury [SCI]. UTIs are increasingly difficult and expensive to treat as the organisms that cause them become more antibiotic resistant...

    Authors: Bonsan Bonne Lee, Swee-Ling Toh, Suzanne Ryan, Judy M. Simpson, Kate Clezy, Laetitia Bossa, Scott A. Rice, Obaydullah Marial, Gerard Weber, Jasbeer Kaur, Claire Boswell-Ruys, Stephen Goodall, James Middleton, Mark Tudehope and George Kotsiou

    Citation: BMC Urology 2016 16:18

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  34. Content type: Research article

    The objective of this study was to determine the factors responsible for peri-operative blood transfusion in a contemporary series of open prostatectomy for benign prostate hyperplasia and thus offer a guide f...

    Authors: Mathew Y. Kyei, George O. Klufio, James E. Mensah, Samuel Gepi-Attee, Kwabena Ampadu, Bernard Toboh and Edward D. Yeboah

    Citation: BMC Urology 2016 16:17

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  35. Content type: Research article

    Excessive mechanical overload may be involved in bladder wall remodelling. Since the activity of Rho kinase is known to be upregulated in the obstructed bladder, we investigate the roles of the RhoA/Rho kinase...

    Authors: Nobuhiro Kushida, Osamu Yamaguchi, Yohei Kawashima, Hidenori Akaihata, Junya Hata, Kei Ishibashi, Ken Aikawa and Yoshiyuki Kojima

    Citation: BMC Urology 2016 16:9

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  36. Content type: Research article

    Previously reported results of a prospective, randomized placebo-controlled study showed that the pollen extract (Cernilton) significantly improved total symptoms, pain, and quality of life in patients with in...

    Authors: Hiromichi Iwamura, Takuya Koie, Osamu Soma, Teppei Matsumoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto and Chikara Ohyama

    Citation: BMC Urology 2015 15:120

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  37. Content type: Research article

    Storage symptoms, associated with benign prostatic hyperplasia (BPH), often co-exist with voiding symptoms in men with lower urinary tract symptoms (LUTS). Storage symptoms are likely to be most bothersome, an...

    Authors: Jameel Nazir, Lars Heemstra, Anke van Engen, Zalmai Hakimi and Cristina Ivanescu

    Citation: BMC Urology 2015 15:41

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  38. Content type: Research article

    We designed this experiment to elucidate the relationship between the expression of brain derived-neurotrophic factor (BDNF), the expression of granulocyte-colony stimulating factor (G-CSF), and the developmen...

    Authors: Seung Mo Yuk, Ju Hyun Shin, Ki Hak Song, Yong Gil Na, Jae Sung Lim and Chong Koo Sul

    Citation: BMC Urology 2015 15:37

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  39. Content type: Research article

    Protein Kinase C (PKC) dysfunction is implicated in a variety of smooth muscle disorders including detrusor overactivity associated with frequency and urgency of micturition. In this study, we aimed to evaluat...

    Authors: Joseph A Hypolite, Shaohua Chang, Alan J Wein, Samuel Chacko and Anna P Malykhina

    Citation: BMC Urology 2015 15:34

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  40. Content type: Research article

    Most studies focusing on progression of BPH have been limited to the relationship between age and BPH progression, and only few studies have focused on the time duration to start treatment. This study aimed to...

    Authors: Sung Ryul Shim, Jae Heon Kim, Hoon Choi, Jae Hyun Bae, Hae Joon Kim, Soon-Sun Kwon, Byung Chul Chun and Won Jin Lee

    Citation: BMC Urology 2015 15:30

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  41. Content type: Research article

    The aim of this study was to compare pelvic floor muscle (PFM) strength using transvaginal digital palpation in healthy continent women in different age groups, and to compare the inter- and intra-rater reliab...

    Authors: Dulcegleika VB Sartori, Monica O Gameiro, Hamilto A Yamamoto, Paulo R Kawano, Rodrigo Guerra, Carlos R Padovani and João L Amaro

    Citation: BMC Urology 2015 15:29

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  42. Content type: Research article

    A previous study showed that foot stimulation can delay the bladder filling sensation and increase bladder volume in healthy humans without OAB. The aim of this study was to determine whether or not electrical...

    Authors: Guoqing Chen, Limin Liao and Di Miao

    Citation: BMC Urology 2015 15:26

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  43. Content type: Research article

    We produced a novel model of bladder outlet obstruction (BOO) by periurethral injection of hyaluronic acid and compared the cystometric features, postoperative complications, and histopathological changes of t...

    Authors: Yongquan Wang, Zhiyong Xiong, Wei Gong, Zhansong Zhou and Gensheng Lu

    Citation: BMC Urology 2015 15:8

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