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Voiding dysfunction

Section edited by Cosimo de Nunzio and Stephen Kraus

This section considers submissions relating to the management of urological male and female voiding dysfunction, including neurological disorders and prostatic diseases. (NOTE: Articles dealing with the diagnosis or treatment of prostate cancer should be submitted to the "Urological oncology" section)

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  1. In last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in...

    Authors: Mauro Gacci, Arcangelo Sebastianelli, Matteo Salvi, Cosimo De Nunzio, Linda Vignozzi, Giovanni Corona, Tommaso Jaeger, Tommaso Chini, Giorgio Ivan Russo, Mario Maggi, Giuseppe Morgia, Andrea Tubaro, Marco Carini and Sergio Serni

    Citation: BMC Urology 2017 17:22

    Content type: Research article

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  2. Intermittent catheterisation is the method of choice for the management of bladder dysfunctions. Different urinary catheters are available, but there is conflicting evidence on which type of catheter is best. ...

    Authors: Carla Rognoni and Rosanna Tarricone

    Citation: BMC Urology 2017 17:4

    Content type: Research article

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  3. This study was designed to evaluate the efficacy and safety of fulranumab, a fully human monoclonal antibody directed against nerve growth factor (NGF), for pain relief in patients with interstitial cystitis/b...

    Authors: Hao Wang, Lucille J. Russell, Kathleen M. Kelly, Steven Wang and John Thipphawong

    Citation: BMC Urology 2017 17:2

    Content type: Research article

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  4. Lower urinary tract symptoms are highly prevalent and a large proportion of these symptoms are known to be associated with a dysfunction of the afferent pathways. Diagnostic tools for an objective and reproduc...

    Authors: Stéphanie van der Lely, Martina Stefanovic, Melanie R. Schmidhalter, Marta Pittavino, Reinhard Furrer, Martina D. Liechti, Martin Schubert, Thomas M. Kessler and Ulrich Mehnert

    Citation: BMC Urology 2016 16:69

    Content type: Study protocol

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  5. Lower Urinary Tract Symptoms (LUTS) in men are a common clinical problem in urology and have been historically strictly linked to benign prostatic hyperplasia (BPH), which may lead to bladder outlet obstructio...

    Authors: Simone Albisinni, Ibrahim Biaou, Quentin Marcelis, Fouad Aoun, Cosimo De Nunzio and Thierry Roumeguère

    Citation: BMC Urology 2016 16:58

    Content type: Research article

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  6. To assess the efficacy and safety of intradetrusor onabotulinumtoxinA (OnabotA) injection treatment in patients with neurogenic lower urinary tract dysfunction (NLUTD), especially for patients with Parkinson d...

    Authors: Stephanie C. Knüpfer, Susanne A. Schneider, Mareike M. Averhoff, Carsten M. Naumann, Günther Deuschl, Klaus-Peter Jünemann and Moritz F. Hamann

    Citation: BMC Urology 2016 16:55

    Content type: Research article

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  7. To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT) as monotherapy or combined with tolterodine in women with overactive bladder (OAB).

    Authors: Dong-dong Xiao, Jian-wei Lv, Xin Xie, Xing-wei Jin, Mu-jun Lu and Yuan Shao

    Citation: BMC Urology 2016 16:49

    Content type: Research article

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  8. Mirabegron is a β3-adrenoreceptor agonist developed for treatment of overactive bladder (OAB). α1-Adrenergic receptor blockers are effective for lower urinary tract symptoms (LUTS) in male patients. However, t...

    Authors: Tomohiro Matsuo, Yasuyoshi Miyata, Katsura Kakoki, Miki Yuzuriha, Akihiro Asai, Kojiro Ohba and Hideki Sakai

    Citation: BMC Urology 2016 16:45

    Content type: Research article

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  9. The activation of TRPA1 channel is implicated in hyper-reflexic micturition similar to overactive bladder. In this study, we aimed to investigate the effects of blocking TRPA1 via intrathecal administration of...

    Authors: Zhipeng Chen, Shuqi Du, Chuize Kong, Zhe Zhang and Al-dhabi Mokhtar

    Citation: BMC Urology 2016 16:33

    Content type: Research article

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  10. Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90–95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can...

    Authors: Giorgio Bozzini, Marco Provenzano, Nicolò Buffi, Mauro Seveso, Giovanni Lughezzani, Giorgio Guazzoni, Alberto Mandressi and Gianluigi Taverna

    Citation: BMC Urology 2016 16:25

    Content type: Research article

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  11. Urinary tract infections [UTIs] are very common in people with Spinal Cord Injury [SCI]. UTIs are increasingly difficult and expensive to treat as the organisms that cause them become more antibiotic resistant...

    Authors: Bonsan Bonne Lee, Swee-Ling Toh, Suzanne Ryan, Judy M. Simpson, Kate Clezy, Laetitia Bossa, Scott A. Rice, Obaydullah Marial, Gerard Weber, Jasbeer Kaur, Claire Boswell-Ruys, Stephen Goodall, James Middleton, Mark Tudehope and George Kotsiou

    Citation: BMC Urology 2016 16:18

    Content type: Study protocol

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  12. The objective of this study was to determine the factors responsible for peri-operative blood transfusion in a contemporary series of open prostatectomy for benign prostate hyperplasia and thus offer a guide f...

    Authors: Mathew Y. Kyei, George O. Klufio, James E. Mensah, Samuel Gepi-Attee, Kwabena Ampadu, Bernard Toboh and Edward D. Yeboah

    Citation: BMC Urology 2016 16:17

    Content type: Research article

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  13. Excessive mechanical overload may be involved in bladder wall remodelling. Since the activity of Rho kinase is known to be upregulated in the obstructed bladder, we investigate the roles of the RhoA/Rho kinase...

    Authors: Nobuhiro Kushida, Osamu Yamaguchi, Yohei Kawashima, Hidenori Akaihata, Junya Hata, Kei Ishibashi, Ken Aikawa and Yoshiyuki Kojima

    Citation: BMC Urology 2016 16:9

    Content type: Research article

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  14. Previously reported results of a prospective, randomized placebo-controlled study showed that the pollen extract (Cernilton) significantly improved total symptoms, pain, and quality of life in patients with in...

    Authors: Hiromichi Iwamura, Takuya Koie, Osamu Soma, Teppei Matsumoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto and Chikara Ohyama

    Citation: BMC Urology 2015 15:120

    Content type: Research article

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  15. Storage symptoms, associated with benign prostatic hyperplasia (BPH), often co-exist with voiding symptoms in men with lower urinary tract symptoms (LUTS). Storage symptoms are likely to be most bothersome, an...

    Authors: Jameel Nazir, Lars Heemstra, Anke van Engen, Zalmai Hakimi and Cristina Ivanescu

    Citation: BMC Urology 2015 15:41

    Content type: Research article

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  16. We designed this experiment to elucidate the relationship between the expression of brain derived-neurotrophic factor (BDNF), the expression of granulocyte-colony stimulating factor (G-CSF), and the developmen...

    Authors: Seung Mo Yuk, Ju Hyun Shin, Ki Hak Song, Yong Gil Na, Jae Sung Lim and Chong Koo Sul

    Citation: BMC Urology 2015 15:37

    Content type: Research article

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  17. Protein Kinase C (PKC) dysfunction is implicated in a variety of smooth muscle disorders including detrusor overactivity associated with frequency and urgency of micturition. In this study, we aimed to evaluat...

    Authors: Joseph A Hypolite, Shaohua Chang, Alan J Wein, Samuel Chacko and Anna P Malykhina

    Citation: BMC Urology 2015 15:34

    Content type: Research article

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  18. Most studies focusing on progression of BPH have been limited to the relationship between age and BPH progression, and only few studies have focused on the time duration to start treatment. This study aimed to...

    Authors: Sung Ryul Shim, Jae Heon Kim, Hoon Choi, Jae Hyun Bae, Hae Joon Kim, Soon-Sun Kwon, Byung Chul Chun and Won Jin Lee

    Citation: BMC Urology 2015 15:30

    Content type: Research article

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  19. The aim of this study was to compare pelvic floor muscle (PFM) strength using transvaginal digital palpation in healthy continent women in different age groups, and to compare the inter- and intra-rater reliab...

    Authors: Dulcegleika VB Sartori, Monica O Gameiro, Hamilto A Yamamoto, Paulo R Kawano, Rodrigo Guerra, Carlos R Padovani and João L Amaro

    Citation: BMC Urology 2015 15:29

    Content type: Research article

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  20. A previous study showed that foot stimulation can delay the bladder filling sensation and increase bladder volume in healthy humans without OAB. The aim of this study was to determine whether or not electrical...

    Authors: Guoqing Chen, Limin Liao and Di Miao

    Citation: BMC Urology 2015 15:26

    Content type: Research article

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  21. We produced a novel model of bladder outlet obstruction (BOO) by periurethral injection of hyaluronic acid and compared the cystometric features, postoperative complications, and histopathological changes of t...

    Authors: Yongquan Wang, Zhiyong Xiong, Wei Gong, Zhansong Zhou and Gensheng Lu

    Citation: BMC Urology 2015 15:8

    Content type: Research article

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  22. Adenosine-5′-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential ...

    Authors: Kiren Gill, Harry Horsley, Anthony S Kupelian, Gianluca Baio, Maria De Iorio, Sanchutha Sathiananamoorthy, Rajvinder Khasriya, Jennifer L Rohn, Scott S Wildman and James Malone-Lee

    Citation: BMC Urology 2015 15:7

    Content type: Research article

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  23. To investigate the expression of parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor 1 (PTH1R) in clinical specimens of normal and diseased bladders. PTHrP is a unique stretch-induced endogenous det...

    Authors: Nobuyuki Nishikawa, Rie Yago, Yuichiro Yamazaki, Hiromitsu Negoro, Mari Suzuki, Masaaki Imamura, Yoshinobu Toda, Kazunari Tanabe, Osamu Ogawa and Akihiro Kanematsu

    Citation: BMC Urology 2015 15:2

    Content type: Research article

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  24. Aim of this study was to make a comparison between penile cuff test (PCT) and standard pressure-flow study (PFS) in the preoperative evaluation of patients candidates for trans-urethral resection of prostate (...

    Authors: Daniele Bianchi, Angelo Di Santo, Gabriele Gaziev, Roberto Miano, Stefania Musco, Giuseppe Vespasiani and Enrico Finazzi Agrò

    Citation: BMC Urology 2014 14:103

    Content type: Research article

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  25. Radical prostatectomy (RP) is the most common treatment for patients with localized prostate cancer. Urinary incontinence (UI) is a significant bothersome sequela after radical prostatectomy that may dramatica...

    Authors: Wei Wang, Qing Mei Huang, Feng Ping Liu and Qi Qi Mao

    Citation: BMC Urology 2014 14:99

    Content type: Research article

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  26. Acute hypokalaemic paralysis is characterised by acute flaccid muscle weakness and has a complex aetiological spectrum. Herein we report, for the first time, a case of unilateral adrenal hyperplasia accompanie...

    Authors: Bo Yang, Yuan Yang, Wenling Tu, Ying Shen and Qiang Dong

    Citation: BMC Urology 2014 14:96

    Content type: Case report

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  27. Irrigation or washouts of the bladder are usually performed in various clinical settings. In the 1980s Elliot and colleagues argued that urothelial damage could occur after washouts and irrigations of the blad...

    Authors: Marco Di Paolo, Valentina Bugelli, Alessandro Di Luca and Emanuela Turillazzi

    Citation: BMC Urology 2014 14:91

    Content type: Case report

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  28. The causality of overactive bladder syndrome (OAB) is still not fully understood. Several studies indicate a significant increase of prostaglandin E2 (PGE2) in patients with OAB. However, in order to clarify w...

    Authors: Axel Hegele, Sonja Knippschild, Carsten Frohme, Jörg Hänze, Peter Olbert and Rainer Hofmann

    Citation: BMC Urology 2014 14:85

    Content type: Research article

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  29. Overactive bladder (OAB)/ storage lower urinary tract symptoms (LUTS) have a high prevalence affecting up to 90% of men over 80 years. The role of sufficient therapies appears crucial. In the present review, w...

    Authors: Mauro Gacci, Giacomo Novara, Cosimo De Nunzio, Andrea Tubaro, Riccardo Schiavina, Eugenio Brunocilla, Arcangelo Sebastianelli, Matteo Salvi, Matthias Oelke, Stavros Gravas, Marco Carini and Sergio Serni

    Citation: BMC Urology 2014 14:84

    Content type: Research article

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  30. The control of the lower urinary tract is a complex, multilevel process involving both the peripheral and central nervous system. Due to lesions of the neuraxis, most spinal cord injury patients suffer from ne...

    Authors: Lorenz Leitner, Matthias Walter, Patrick Freund, Ulrich Mehnert, Lars Michels, Spyros Kollias and Thomas M Kessler

    Citation: BMC Urology 2014 14:68

    Content type: Study protocol

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  31. We have observed different clinical responses to botulinum toxin A (BTX-A) in patients who had similar urodynamic parameters before the procedure. Furthermore, some bladders evaluated by cystography and cystos...

    Authors: Ronaldo Alvarenga Álvares, Ivana Duval Araújo and Marcelo Dias Sanches

    Citation: BMC Urology 2014 14:66

    Content type: Research article

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  32. Sacral neuromodulation has become a well-established and widely accepted treatment for refractory non-neurogenic lower urinary tract dysfunction, but its value in patients with a neurological cause is unclear....

    Authors: Stephanie C Knüpfer, Martina D Liechti, Livio Mordasini, Dominik Abt, Daniel S Engeler, Jens Wöllner, Jürgen Pannek, Bernhard Kiss, Fiona C Burkhard, Marc P Schneider, Elena Miramontes, Alfons G Kessels, Lucas M Bachmann and Thomas M Kessler

    Citation: BMC Urology 2014 14:65

    Content type: Study protocol

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  33. Bioactive compounds from plants (i.e., Serenoa repens) are often used in medicine in the treatment of several pathologies, among which benign prostatic hyperplasia (BPH) associated to lower urinary tract symptoms...

    Authors: Celeste De Monte, Simone Carradori, Arianna Granese, Giovanni Battista Di Pierro, Costantino Leonardo and Cosimo De Nunzio

    Citation: BMC Urology 2014 14:63

    Content type: Review

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  34. The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy a...

    Authors: Jae Heon Kim, Hoon Choi, Hwa Yeon Sun, Seung Whan Doo, Jong Hyun Yoon, Won Jae Yang, Byung Wook Yoo, Joyce Mary Kim, Soon-Sun Kwon, Eun Seop Song, Hong Jun Lee, Ik Sung Lim and Yun Seob Song

    Citation: BMC Urology 2014 14:60

    Content type: Research article

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  35. Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition t...

    Authors: Gian Maria Busetto, Riccardo Giovannone, Matteo Ferro, Stefano Tricarico, Francesco Del Giudice, Deliu Victor Matei, Ottavio De Cobelli, Vincenzo Gentile and Ettore De Berardinis

    Citation: BMC Urology 2014 14:53

    Content type: Research article

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  36. Botulinum toxin A (BoNT-A) is a new treatment modality in various causes of bladder dysfunction; like neurogenic detrusor overactivity and overactive bladder. The best technique of administrating BoNT-A in pat...

    Authors: Janneke IM van Uhm, Goedele MA Beckers, Willem J van der Laarse, Eric JH Meuleman, Albert A Geldof and Jakko A Nieuwenhuijzen

    Citation: BMC Urology 2014 14:37

    Content type: Technical advance

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  37. Hem-o-lok clips are widely used during robot-assisted and laparoscopic radical prostatectomy to control the lateral pedicles. There are a few reports of hem-o-lok clip migration into the bladder or vesico-uret...

    Authors: Luigi Cormio, Paolo Massenio, Giuseppe Lucarelli, Giuseppe Di Fino, Oscar Selvaggio, Salvatore Micali and Giuseppe Carrieri

    Citation: BMC Urology 2014 14:21

    Content type: Case report

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  38. Only limited data are available on the outcome of tension-free obturator tape (TOT) procedures in overweight and obese women. We would like to verify the objective and subjective outcomes of TOT in women with ...

    Authors: Carsten Frohme, Friederike Ludt, Zoltan Varga, Peter J Olbert, Rainer Hofmann and Axel Hegele

    Citation: BMC Urology 2014 14:20

    Content type: Research article

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  39. Higher physical activity levels are continence-protective in non-prostate cancer populations. Primary aims of this study were to investigate changes in physical activity levels over the perioperative period in...

    Authors: Sean F Mungovan, Bregtje P Huijbers, Andrew D Hirschhorn and Manish I Patel

    Citation: BMC Urology 2013 13:67

    Content type: Research article

    Published on:

  40. Percutaneous Tibial Nerve Stimulation (PTNS) has been proposed for the treatment of overactive bladder syndrome (OAB), non-obstructive urinary retention (NOUR), neurogenic bladder, paediatric voiding dysfuncti...

    Authors: Gabriele Gaziev, Luca Topazio, Valerio Iacovelli, Anastasios Asimakopoulos, Angelo Di Santo, Cosimo De Nunzio and Enrico Finazzi-Agrò

    Citation: BMC Urology 2013 13:61

    Content type: Research article

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