Articles

The relationship between depression and overactive bladder/urinary incontinence symptoms in the clinical OAB population

To investigate the relationship between depression and overactive bladder (OAB)/urinary incontinence symptoms among the clinical OAB population.

Authors: H. Henry Lai, Baixin Shen, Amar Rawal and Joel Vetter

Systematic review and meta-analysis of randomised trials of perioperative outcomes comparing robot-assisted versus open radical cystectomy

With the introduction of robotic surgery, whether the robot-assisted radical cystectomy (RARC) could reduce the perioperative morbidity compared with Open radical cystectomy (ORC) was unknown.

Authors: Zhiyuan Shen and Zhongquan Sun

New medical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia and future perspectives

Lower Urinary Tract Symptoms (LUTS) in men are a common clinical problem in urology and have been historically strictly linked to benign prostatic hyperplasia (BPH), which may lead to bladder outlet obstructio...

Authors: Simone Albisinni, Ibrahim Biaou, Quentin Marcelis, Fouad Aoun, Cosimo De Nunzio and Thierry Roumeguère

Erratum to: Defining competency in flexible cystoscopy: a novel approach using cumulative Sum analysis

Authors: Kenneth R. MacKenzie and Jonathan Aning

Cancer-specific and overall survival in patients with recurrent prostate cancer who underwent salvage extended pelvic lymph node dissection

The aim was to evaluate cancer-specific survival (CSS) and overall survival (OS) in patients with prostate cancer (PCa) recurrence who underwent salvage extended pelvic lymph node dissection (ePLND), taking in...

Authors: Daniar K. Osmonov, Alexey V. Aksenov, David Trick, Carsten M. Naumann, Moritz F. Hamann, Amr Abou Faddan and Klaus-Peter Jünemann

Preserved micturition after intradetrusor onabotulinumtoxinA injection for treatment of neurogenic bladder dysfunction in Parkinson’s disease

To assess the efficacy and safety of intradetrusor onabotulinumtoxinA (OnabotA) injection treatment in patients with neurogenic lower urinary tract dysfunction (NLUTD), especially for patients with Parkinson d...

Authors: Stephanie C. Knüpfer, Susanne A. Schneider, Mareike M. Averhoff, Carsten M. Naumann, Günther Deuschl, Klaus-Peter Jünemann and Moritz F. Hamann

Diagnostic and treatment factors associated with poor survival from prostate cancer are differentially distributed between regional and metropolitan Victoria, Australia

Men diagnosed with prostate cancer (PCa) in specific regional areas in Victoria, Australia have a poorer five-year survival rate compared to men living elsewhere in Victoria. This study aims to describe patter...

Authors: Rasa Ruseckaite, Fanny Sampurno, Jeremy Millar, Mark Frydenberg and Sue Evans

Rates of prostate surgery and acute urinary retention for benign prostatic hyperplasia in men treated with dutasteride or finasteride

Previous studies have suggested a greater benefit for various outcomes in men diagnosed with benign prostatic hyperplasia (BPH) who are treated with dutasteride than for men treated with finasteride. This stud...

Authors: Josephina G. Kuiper, Irene D. Bezemer, Maurice T. Driessen, Averyan Vasylyev, Claus G. Roehrborn, Fernie J. A. Penning-van Beest and Ron M. C. Herings

Clinical significance of CDH13 promoter methylation as a biomarker for bladder cancer: a meta-analysis

Methylation of the tumor suppressor gene H-cadherin (CDH13) has been reported in many cancers. However, the clinical effect of the CDH13 methylation status of patients with bladder cancer remains to be clarified.

Authors: Feng Chen, Tao Huang, Yu Ren, Junjun Wei, Zhongguan Lou, Xue Wang, Xiaoxiao Fan, Yirun Chen, Guobin Weng and Xuping Yao

Clinical importance of the antibiotic regimen in transrectal ultrasound-guided biopsy: quinolone versus cephalosporin

Quinolone is recommended as an antimicrobial prophylaxis to prevent infectious complication after transrectal ultrasound-guided biopsy, but the increased appearance of quinolone-resistant organism has raised c...

Authors: Jung Keun Lee, Sangchul Lee, Sung Kyu Hong, Seok-Soo Byun and Sang Eun Lee

Physical activity before radical prostatectomy reduces sick leave after surgery - results from a prospective, non-randomized controlled clinical trial (LAPPRO)

Studies have reported that early physical rehabilitation after surgical procedures is associated with improved outcome measured as shorter hospital stay and enhanced recovery. The aim of this study was to expl...

Authors: E. Angenete, U. Angerås, M. Börjesson, J. Ekelund, M. Gellerstedt, T. Thorsteinsdottir, G. Steineck and E. Haglind

The combination of herbal medicine Weng-li-tong with Tolterodine may be better than Tolterodine alone in the treatment of overactive bladder in women: a randomized placebo-controlled prospective trial

To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT) as monotherapy or combined with tolterodine in women with overactive bladder (OAB).

Authors: Dong-dong Xiao, Jian-wei Lv, Xin Xie, Xing-wei Jin, Mu-jun Lu and Yuan Shao

10-Year experience regarding the reliability and morbidity of radio guided lymph node biopsy in penile cancer patients and the associated radiation exposure of medical staff in this procedure

The guidelines of the European Association of Urologists (EAU), of the German Society of Nuclear Medicine (DGN), and the European Society for Medical Oncology (ESMO) recommend sentinel lymph node biopsy (SLNB)...

Authors: Ulf Lützen, Carsten Maik Naumann, Jens Dischinger, Marlies Marx, René Baumann, Yi Zhao, Michael Jüptner, Daniar Osmonov, Katrin Bothe, Klaus-Peter Jünemann and Maaz Zuhayra

Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?

Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient’s health-related qu...

Authors: Nishi Karunasinghe, Yifei Zhu, Dug Yeo Han, Katja Lange, Shuotun Zhu, Alice Wang, Stephanie Ellett, Jonathan Masters, Megan Goudie, Justin Keogh, Benji Benjamin, Michael Holmes and Lynnette R. Ferguson

A Korean multi-center, real-world, retrospective study of first-line pazopanib in unselected patients with metastatic renal clear-cell carcinoma

The efficacy and/or tolerability of pazopanib in patients with metastatic renal cell carcinoma (mRCC) have been found to differ in Western and Asian populations. This retrospective multicenter study analyzed t...

Authors: Moon Jin Kim, Se Hoon Park, Jae-Lyun Lee, Se-Hoon Lee, Su Jin Lee and Ho Yeong Lim

The efficacy of mirabegron additional therapy for lower urinary tract symptoms after treatment with α1-adrenergic receptor blocker monotherapy: prospective analysis of elderly men

Mirabegron is a β3-adrenoreceptor agonist developed for treatment of overactive bladder (OAB). α1-Adrenergic receptor blockers are effective for lower urinary tract symptoms (LUTS) in male patients. However, t...

Authors: Tomohiro Matsuo, Yasuyoshi Miyata, Katsura Kakoki, Miki Yuzuriha, Akihiro Asai, Kojiro Ohba and Hideki Sakai

MMP9 overexpression is associated with good surgical outcome in children with UPJO: Preliminary results

Ureteropelvic junction obstruction (UPJO) diagnosed prenatally occurs in 1:150 – 1:1200 pregnancies. Although many studies investigating the molecular changes of this obstructed segment have been performed, th...

Authors: Sabrina Thalita Reis, Kátia R. M. Leite, Nayara Izabel Viana, Roberto Iglesias Lopes, Caio Martins Moura, Renato F. Ivanovic, Marcos Machado, Francisco Tibor Denes, Amilcar Giron, William Carlos Nahas, Miguel Srougi and Carlo C. Passerotti

Multi-disciplinary surgical approach to the management of patients with renal cell carcinoma with venous tumor thrombus: 15 year experience and lessons learned

The management of patients with renal cell carcinoma (RCC) with venous tumor thrombus (VTT) is challenging. We report our 15 year experience in the management of patients with RCC with VTT utilizing a multidis...

Authors: Bishoy A. Gayed, Ramy Youssef, Oussama Darwish, Payal Kapur, Aditya Bagrodia, James Brugarolas, Ganesh Raj, J. Michael DiMaio, Arthur Sagalowsky and Vitaly Margulis

Obesity is associated with increased risk of invasive penile cancer

To validate the association between obesity and penile cancer at a population level, we conducted a matched case–control study linking the Iowa Department of Motor Vehicles Drivers’ License Database (DLD) with...

Authors: Kerri T. Barnes, Bradley D. McDowell, Anna Button, Brian J. Smith, Charles F. Lynch and Amit Gupta

Characteristics and repair outcome of patients with Vesicovaginal fistula managed in Jimma University teaching Hospital, Ethiopia

In Ethiopia, about 9000 fistula cases are estimated to occur every year with an incidence of 2.2/1000 women. This study was aimed to determine obstetric fistula characteristics and surgical repair outcomes amo...

Authors: Demisew Anemu Sori, Ahadu Workineh Azale and Desta Hiko Gemeda

Clinical characteristics of XP11.2 translocation/TFE3 gene fusion renal cell carcinoma: a systematic review and meta-analysis of observational studies

Renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 RCC) is a rare subtype of RCC which is firstly described as a distinct entity in 2004 so that clinical characteristics o...

Authors: Xiangming Cheng, Weidong Gan, Gutian Zhang, Xiaogong Li and Hongqian Guo

A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary prostate biopsy

The standard of care in patients with suspected prostate cancer (PCa) is systematic prostate biopsies. This approach leads to unnecessary biopsies in patients without PCa and also to the detection of clinical ...

Authors: Yngve Nygård, Svein A. Haukaas, Ole J. Halvorsen, Karsten Gravdal, Jannicke Frugård, Lars A. Akslen and Christian Beisland

Acute bacterial prostatitis and abscess formation

The purpose of this study was to identify risk factors for abscess formation in acute bacterial prostatitis, and to compare treatment outcomes between abscess group and non-abscess group.

Authors: Dong Sup Lee, Hyun-Sop Choe, Hee Youn Kim, Sun Wook Kim, Sang Rak Bae, Byung Il Yoon and Seung-Ju Lee

Spontaneous ureteric rupture, a reality or a faux pas?

Rupture of the urinary collecting system with or without any perinephric extravasation is an extremely rare occurrence and usually known to occur following an obstructive pathology.

Authors: Gaurav Aggarwal and Samiran Das Adhikary

Case report: Xanthogranulomutous pyelonephritis presenting as “Wilms’ tumor”

Xanthogranulomatous pyelonephritis (XGP) is a rare renal tumor that arises as a complication of chronic obstructive pyelonephritis of uncertain etiology. It is primarily an adult tumor seen occasionally in chi...

Authors: Shakilu Iumanne, Aika Shoo, Larry Akoko and Patricia Scanlan

Pazopanib as a second-line treatment for non-cytokine-treated metastatic renal cell carcinoma: a meta-analysis of the effect of treatment

The currently recommended treatment algorithm for patients with advanced renal cell carcinoma who fail the first-line targeted therapy does not normally include pazopanib as a second-line treatment option. It ...

Authors: Victor C. Kok and Jung-Tsung Kuo

TMPRSS2:ERG gene aberrations may provide insight into pT stage in prostate cancer

TMPRSS2:ERG gene aberration may be a novel marker that improves risk stratification of prostate cancer before definitive cancer therapy, but studies have been inconclusive.

Authors: Zoran Krstanoski, Nadja Kokalj Vokac, Andreja Zagorac, Boris Pospihalj, Miha Munda, Saso Dzeroski and Rastko Golouh

Intrathecal administration of TRPA1 antagonists attenuate cyclophosphamide-induced cystitis in rats with hyper-reflexia micturition

The activation of TRPA1 channel is implicated in hyper-reflexic micturition similar to overactive bladder. In this study, we aimed to investigate the effects of blocking TRPA1 via intrathecal administration of...

Authors: Zhipeng Chen, Shuqi Du, Chuize Kong, Zhe Zhang and Al-dhabi Mokhtar

Bone management in Japanese patients with prostate cancer: hormonal therapy leads to an increase in the FRAX score

Osteoporosis is a common consequence of androgen deprivation therapy (ADT) for prostate cancer. Up to 20 % of men on ADT have suffered from fractures within 5 years. The WHO Fracture Risk Assessment Tool (FRAX...

Authors: Takashi Kawahara, Shusei Fusayasu, Koji Izumi, Yumiko Yokomizo, Hiroki Ito, Yusuke Ito, Kayo Kurita, Kazuhiro Furuya, Hisashi Hasumi, Narihiko Hayashi, Yasuhide Myoshi, Hiroshi Miyamoto, Masahiro Yao and Hiroji Uemura

The diagnostic accuracy of urine-based tests for bladder cancer varies greatly by patient

Spectrum effects refer to the phenomenon that test performance varies across subgroups of a population. When spectrum effects occur during diagnostic testing for cancer, difficult patient misdiagnoses can occu...

Authors: Ajay Gopalakrishna, Thomas A. Longo, Joseph J. Fantony, Richmond Owusu, Wen-Chi Foo, Rajesh Dash and Brant A. Inman

Defining competency in flexible cystoscopy: a novel approach using cumulative Sum analysis

Flexible cystoscopy (FC) is one of the most frequently performed urological intervention. Cumulative sum analysis (CUSUM) allows objective assessment of a proceduralist’s performance to ensure acceptable outco...

Authors: Kenneth R. MacKenzie and Jonathan Aning

Pure retroperitoneal natural orifice translumenal endoscopic surgery (NOTES) transvaginal nephrectomy using standard laparoscopic instruments: a safety and feasibility study in a porcine model

Among the different organs used for NOTES (natural orifice translumenal endoscopic surgery) technique, the transvaginal approach may be the optimal choice because of a simple and secure closure of colpotomy si...

Authors: Dechao Wei, Yili Han, Mingchuan Li, Yongxing Wang, Yatong Chen, Yong Luo and Yongguang Jiang

Hyaluronic acid-carboxymethylcellulose reduced postoperative bowel adhesions following laparoscopic urologic pelvic surgery: a prospective, randomized, controlled, single-blind study

To assess the anti-adhesive effect of treatment with hyaluronic acid-carboxymethylcellulose following laparoscopic radical prostatectomy.

Authors: U-Syn Ha, Jun Sung Koh, Kang Jun Cho, Byung Il Yoon, Kyu Won Lee, Sung Hoo Hong and Ji Youl Lee

An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men

Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90–95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can...

Authors: Giorgio Bozzini, Marco Provenzano, Nicolò Buffi, Mauro Seveso, Giovanni Lughezzani, Giorgio Guazzoni, Alberto Mandressi and Gianluigi Taverna

Biochemical recurrence-free survival and pathological outcomes after radical prostatectomy for high-risk prostate cancer

We propose to improve the prognostic assessment after radical prostatectomy (RP) by dividing high-risk prostate cancer (hrPCa) (according to the d’Amico classification) into subgroups combining 1, 2 or 3 crite...

Authors: Jean-Baptiste Beauval, Mathieu Roumiguié, Thomas Filleron, Thibaut Benoit, Alexandre de la Taille, Bernard Malavaud, Laurent Salomon, Michel Soulié and Guillaume Ploussard

Association of early PSA decline and time to PSA progression in abiraterone acetate-treated metastatic castration-resistant prostate cancer; a post-hoc analysis of Japanese phase 2 trials

Previous studies have demonstrated an association between prostate-specific antigen (PSA) kinetics and predictive value for treatment outcomes. Abiraterone acetate (AA) is a newly approved cytochrome-P450C17 i...

Authors: Masahiko Nakayama, Hisanori Kobayashi, Tomihiro Takahara, Ryo Oyama, Keiichiro Imanaka and Kazutake Yoshizawa

Intestinal metaplasia of the bladder in 89 patients: a study with emphasis on long-term outcome

Intestinal metaplasia of the bladder is an uncommon glandular proliferation. We examined a large series of intestinal metaplasia for the clinicopathological features and discuss the significance of this lesion.

Authors: Zhixiang Xin, Chenhui Zhao, Tao Huang, Zhaohui Zhang, Chenlong Chu, Caifeng Lu, Min Wu and Wenlong Zhou

The efficacy and safety of silodosin for the treatment of ureteral stones: a systematic review and meta-analysis

To evaluate the efficacy and safety of silodosin as a medical expulsive therapy for ureteral stones by means of a systematic review and meta-analysis.

Authors: Diandong Yang, Jitao Wu, Hejia Yuan and Yuanshan Cui

Female urinary incontinence and wellbeing: results from a multi-national survey

Previous research has shown that the severity of symptoms of urinary incontinence impacts on quality of life and wellbeing.

Authors: Andrew P. Smith

Prolonged CT urography in duplex kidney

Duplex kidney is a common anomaly that is frequently associated with multiple complications. Typical computed tomography urography (CTU) includes four phases (unenhanced, arterial, parenchymal and excretory) a...

Authors: Honghan Gong, Lei Gao, Xi-Jian Dai, Fuqing Zhou, Ning Zhang, Xianjun Zeng, Jian Jiang and Laichang He

A novel stepwise micro-TESE approach in non obstructive azoospermia

The purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate (SRR) compared to conventional single TESE biopsy on the same testicle or to contralateral multiple TESE, by empl...

Authors: Giorgio Franco, Filomena Scarselli, Valentina Casciani, Cosimo De Nunzio, Donato Dente, Costantino Leonardo, Pier Francesco Greco, Alessia Greco, Maria Giulia Minasi and Ermanno Greco

Do African-American men need separate prostate cancer screening guidelines?

In 2012, the United States Preventative Services Task Force issued new guidelines recommending that male U.S. residents, irrespective of race, no longer be screened for prostate cancer. In African American men...

Authors: Divya Shenoy, Satyaseelan Packianathan, Allen M. Chen and Srinivasan Vijayakumar

Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a study protocol for a randomised controlled trial

Urinary tract infections [UTIs] are very common in people with Spinal Cord Injury [SCI]. UTIs are increasingly difficult and expensive to treat as the organisms that cause them become more antibiotic resistant...

Authors: Bonsan Bonne Lee, Swee-Ling Toh, Suzanne Ryan, Judy M. Simpson, Kate Clezy, Laetitia Bossa, Scott A. Rice, Obaydullah Marial, Gerard Weber, Jasbeer Kaur, Claire Boswell-Ruys, Stephen Goodall, James Middleton, Mark Tudehope and George Kotsiou

Determinants of peri-operative blood transfusion in a contemporary series of open prostatectomy for benign prostate hyperplasia

The objective of this study was to determine the factors responsible for peri-operative blood transfusion in a contemporary series of open prostatectomy for benign prostate hyperplasia and thus offer a guide f...

Authors: Mathew Y. Kyei, George O. Klufio, James E. Mensah, Samuel Gepi-Attee, Kwabena Ampadu, Bernard Toboh and Edward D. Yeboah

Transvaginal rectocele repair with human dermal allograft interposition and bilateral sacrospinous fixation with a minimum eight-year follow-up

Human dermal allografts have been used for over a decade for interpositional repair of rectoceles. How do dermal allografts perform with regards to success rate and complications with 8 years’ minimum follow-up?

Authors: Serge P. Marinkovic, Scott Hughes, Donghua Xie, Lisa M. Gillen and Christina M. Marinkovic

[−2]proPSA versus ultrasensitive PSA fluctuations over time in the first year from radical prostatectomy, in an high-risk prostate cancer population: A first report

[−2]proPSA and its derivatives have an higher diagnostic accuracy than PSA in predicting prostate cancer (PCa). In alternative to PSA, ultrasensitive PSA (uPSA) and [−2]proPSA could be potentially useful in re...

Authors: S. De Luca, R. Passera, A. Sottile, C. Fiori, R. M. Scarpa and F. Porpiglia

Frequent mismatch-repair defects link prostate cancer to Lynch syndrome

A possible role for prostate cancer in Lynch syndrome has been debated based on observations of mismatch-repair defective tumors and reports of an increased risk of prostate cancer in mutation carriers. Potent...

Authors: Mev Dominguez-Valentin, Patrick Joost, Christina Therkildsen, Mats Jonsson, Eva Rambech and Mef Nilbert

Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases

Assays of molecular biomarkers in urine are non-invasive compared to other body fluids and can be easily repeated. Based on the hypothesis that the secreted markers from the diseased organs may locally release...

Authors: Zhaohui Chen and Jayoung Kim

Abiraterone acetate in metastatic castration-resistant prostate cancer – the unanticipated real-world clinical experience

There is much interest in confirming whether the efficacy of abiraterone acetate (AA) demonstrated within the trial setting is reproducible in routine clinical practice. We report the clinical outcome of metas...

Authors: Darren M. C. Poon, Kuen Chan, S. H. Lee, T. W. Chan, Henry Sze, Eric K. C. Lee, Daisy Lam and Michelle F. T. Chan

Prognostic factors and risk stratification in patients with castration-resistant prostate cancer receiving docetaxel-based chemotherapy

While novel drugs have been developed, docetaxel remains one of the standard initial systemic therapies for castration-resistant prostate cancer (CRPC) patients. Despite the excellent anti-tumor effect of doce...

Authors: Shimpei Yamashita, Yasuo Kohjimoto, Takashi Iguchi, Hiroyuki Koike, Hiroki Kusumoto, Akinori Iba, Kazuro Kikkawa, Yoshiki Kodama, Nagahide Matsumura and Isao Hara