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  1. Lower urinary tract symptoms (LUTS) is the most common complication of diabetes. However, the underlying pathogenesis of cultured negative LUTS (cn-LUTS) in diabetic patients has not been well understood. Nume...

    Authors: Jiawei Chen, Jie Zhao, Ying Cao, Guihao Zhang, Yang Chen, Jialei Zhong, Weina Huang, Jiarong Zeng and Peng Wu

    Citation: BMC Urology 2019 19:78

    Content type: Research article

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  2. Perivesical lymph nodes (PVLNs) are occasionally isolated during grossing of cystectomy specimens. However, the prognostic implications of the involvement of PVLNs in bladder cancer patients, especially those ...

    Authors: Meenal Sharma, Takuro Goto, Zhiming Yang and Hiroshi Miyamoto

    Citation: BMC Urology 2019 19:77

    Content type: Research article

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  3. Total Mesorectal Excision (TME) is the standard surgical technique for the treatment of rectal cancer. However, rates of sexual dysfunction ofup to 50% have been described after TME, and rates of urinary dysfu...

    Authors: Anna Pallisera-Lloveras, Paula Planelles-Soler, Naim Hannaoui, Laura Mora-López, Jesús Muñoz-Rodriguez, Sheila Serra-Pla, Arturo Dominguez-Garcia, Joan Prats-López, Salvador Navarro-Soto and Xavier Serra-Aracil

    Citation: BMC Urology 2019 19:75

    Content type: Study protocol

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  4. Strong evidence comparing effectiveness between nephron-sparing intervention (NSI) and active surveillance (AS) is lacking. Thus, we aim to compare the outcomes of survival, including cancer-specific survival ...

    Authors: Run-Qi Guo and Xiao-Guang Li

    Citation: BMC Urology 2019 19:74

    Content type: Research article

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  5. Patient-related factors such as concern about cancer are believed to influence both men’s decisions to undergo prostate specific antigen (PSA) testing and to have definitive treatment if diagnosed with low ris...

    Authors: Kerri Beckmann, Netty Kinsella, Henrik Olsson, Anna Wallerstedt Lantz, Tobias Nordstrom, Markus Aly, Jan Adolfsson, Martin Eklund and Mieke Van Hemelrijck

    Citation: BMC Urology 2019 19:73

    Content type: Research article

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  6. Functional outcome is an important issue in nephron-sparing surgery. Various nephrometries have been developed to predict renal function preservation. The aim of this study was to examine the applicability of ...

    Authors: Yu-De Wang, Chi-Ping Huang, Chao-Hsiang Chang, Hsi-Chin Wu, Che-Rei Yang, Yu-Ping Wang and Po-Fan Hsieh

    Citation: BMC Urology 2019 19:72

    Content type: Research article

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  7. Due to the usage of various measurement methods and definitions, comparing continence rates after radical prostatectomy is a challenging task. This study compares continence rates based on different methods an...

    Authors: Sigrun Holze, Meinhard Mende, Karl V. Healy, Norbert Koehler, Lutz Gansera, Michael C. Truss, Udo Rebmann, Stephan Degener and Jens-Uwe Stolzenburg

    Citation: BMC Urology 2019 19:70

    Content type: Research article

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  8. The expression level of ribonucleotide reductase subunit M1 (RRM1) is closely related to the effect of gemcitabine-based therapy in advanced bladder cancer. However, the value of RRM1 expression in predicting ...

    Authors: Zhenxing Yang, Bingqiang Fu, Luqiang Zhou, Jie Xu, Ping Hao and Zhenqiang Fang

    Citation: BMC Urology 2019 19:69

    Content type: Research article

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  9. To define a new coefficient to be used in the formula (Volume = L x H x W x Coefficient) that better estimates prostate volume using dimensions of fresh prostates from patients who had transrectal ultrasound (...

    Authors: Saro Aprikian, Murilo Luz, Fadi Brimo, Eleonora Scarlata, Lucie Hamel, Fabio L. Cury, Simon Tanguay, Armen G. Aprikian, Wassim Kassouf and Simone Chevalier

    Citation: BMC Urology 2019 19:68

    Content type: Research article

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  10. Epithelial cell adhesion molecule (EpCAM) expression has been reported in many types of cancer, including prostate cancer (PCa). However, the role of EpCAM expression remains inconsistent. We conducted a meta-...

    Authors: Yu Hu, Qiong Wu, Jialin Gao, Yongrui Zhang and Yuantao Wang

    Citation: BMC Urology 2019 19:67

    Content type: Research article

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  11. The prostate-specific antigen (PSA) -value is often used during the prostate cancer trajectory as a marker of progression or response to treatment. Concerns about PSA-values are often expressed by patients in ...

    Authors: Ulrika Rönningås, Per Fransson, Maja Holm and Agneta Wennman-Larsen

    Citation: BMC Urology 2019 19:66

    Content type: Research article

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  12. The past four years has seen a rapid roll-out of male medical circumcision services in South Africa in response to clinical trials showing circumcision prevents HIV acquisition in heterosexual men. Clinics con...

    Authors: Mmatsie Manentsa, Hilary Mukudu, Nthabiseng Koloane, Ashley Ringane, Eleanor Matta, Neil A. Martinson and Limakatso Lebina

    Citation: BMC Urology 2019 19:65

    Content type: Case report

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  13. This paper describes the testicular cancer trends for incidence, survival, socio-economic status (SES) disparities and second cancer occurrence in Geneva, Switzerland, a high-risk population.

    Authors: Robin Schaffar, Samaksha Pant, Christine Bouchardy, Hyma Schubert and Elisabetta Rapiti

    Citation: BMC Urology 2019 19:64

    Content type: Research article

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  14. To evaluate the efficacy of pelvic plexus block (PPB) in relief pain during transperineal template-guided prostate biopsy (TTPB), compared with conventional periprostatic nerve block (PNB).

    Authors: Xue-fei Ding, Tian-bao Huang, Sheng-ming Lu, Hua-zhi Tao, Xiao-fang Ye, Fei Wang, Yao-zong Xu, Jia-nan Xu, Yu-quan Zhou and Yang Luan

    Citation: BMC Urology 2019 19:63

    Content type: Research article

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  15. Porcine urinary bladders are widely used for uro-pharmacological examinations due to their resemblance to the human organ. However, characterisations of the porcine urothelium at the molecular level are scarce...

    Authors: Dorothea Leonhäuser, Jasmin Kranz, Regina Leidolf, Patrick Arndt, Ulrich Schwantes, Joachim Geyer and Joachim O. Grosse

    Citation: BMC Urology 2019 19:62

    Content type: Research article

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  16. One of the greatest challenges presented with RIRS is the potential for movement of the stone within the operative field associated with diaphragm and chest respiratory excursions due to mechanical ventilation...

    Authors: Nariman Gadzhiev, Ullubiy Oibolatov, Leonid Kolotilov, Sergei Parvanyan, Gagik Akopyan, Sergei Petrov, Courtney M. Cottone, John Sung and Zhamshid Okhunov

    Citation: BMC Urology 2019 19:61

    Content type: Research article

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  17. Despite the fact that testicular cancer presents good prognosis, wide variations in mortality rates have been reported internationally. In Brazil, mortality trends and estimates have not been fully assessed. T...

    Authors: Samara Carollyne Mafra Soares, Katarina Márcia Rodrigues dos Santos, Fabia Cheyenne Gomes de Morais Fernandes, Isabelle Ribeiro Barbosa and Dyego Leandro Bezerra de Souza

    Citation: BMC Urology 2019 19:59

    Content type: Research article

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  18. The use of ureteral access sheath (UAS) during ureteroscopy is controversial. We aimed to explore practice patterns of UAS during ureteroscopy for nephrolithiasis among endourologists worldwide.

    Authors: Dorit Esther Zilberman, Alon Lazarovich, Harry Winkler and Nir Kleinmann

    Citation: BMC Urology 2019 19:58

    Content type: Research article

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  19. Clinical studies assessing the feasibility and accuracy of three stone scoring systems’s (SSSs: Guy’s stone score, CROES nomogram and S.T.O.N.E nephrolithometry scoring system) have reported contradictory outc...

    Authors: Kehua Jiang, Fa Sun, Jianguo Zhu, Guangheng Luo, Peng Zhang, Yong Ban, Gang Shan and Changxiang Liu

    Citation: BMC Urology 2019 19:57

    Content type: Research article

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  20. Transurethral resection (TUR) is the standard operation used for non-muscle invasive bladder cancer (NMIBC). Although most solid tumors are principally removed via single block resection without incising the m...

    Authors: Yasushi Hayashida, Yasuyoshi Miyata, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai, Mitsuru Taba, Shinji Naito and Keisuke Taniguchi

    Citation: BMC Urology 2019 19:56

    Content type: Technical advance

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  21. Many factors including vasoconstrictor agents can interfere with wound healing process. This study aimed to compare the histopathological outcome of injection of two sympathomimetic drugs used during urologic ...

    Authors: Mehdi Shirazi, Mohammad-Bagher Rajabalian, Ali Noorafshan, Saied Karbalay-Doust, Zahra Jahanabadi and Faisal Ahmed

    Citation: BMC Urology 2019 19:55

    Content type: Research article

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  22. There is a change in the position of the remaining anatomical structures of the lower urinary tract system following radical prostatectomy. The aims of this investigation were to describe three novel methods u...

    Authors: Hong Koo Ha, Henk B. Luiting, Petra L. Graham, Manish I. Patel, Jaspreet S. Sandhu, Oguz Akin and Sean F. Mungovan

    Citation: BMC Urology 2019 19:54

    Content type: Technical advance

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  23. Let-7 is one of the earliest discovered microRNAs(miRNAs) and has been reported to be down-regulated in multiple malignant tumors. The effects and molecular mechanisms of let-7i in bladder cancer are still unc...

    Authors: M-M Qin, X. Chai, H-B Huang, G. Feng, X-N Li, J. Zhang, R. Zheng, X-C Liu and C. Pu

    Citation: BMC Urology 2019 19:53

    Content type: Research article

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  24. Testicular epidermoid cysts (TECs) are rare benign testicular neoplasms. As TECs are rarely associated with germ cell tumours (GCTs), the understanding of biological behaviour and clinical management of TEC is...

    Authors: Petra Anheuser, J. Kranz, E. Stolle, D. Höflmayer, F. Büscheck, S. Mühlstädt, G. Lock and K. P. Dieckmann

    Citation: BMC Urology 2019 19:52

    Content type: Research article

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  25. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare hereditary kidney cancer syndrome in which affected individuals are at risk of skin and uterine leiomyomatosis and kidney cancer. HLRCC-asso...

    Authors: Inkeun Park, Young Sup Shim, Heounjeong Go, Bum Sik Hong and Jae Lyun Lee

    Citation: BMC Urology 2019 19:51

    Content type: Case report

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  26. Physicians doubt percutaneous nephrostomy (PCN) insertion on cancer related hydronephrosis patients causes tumor seeding and worse cancer control. In this article, we attempted to determine if preoperative PCN...

    Authors: Guan-Lin Huang, Hao-Lun Luo and Po-Hui Chiang

    Citation: BMC Urology 2019 19:50

    Content type: Research article

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  27. Conflicting evidence exists regarding the effect of hypertension on the prognosis of metastatic renal cell carcinoma (mRCC) patients treated with tyrosine kinase inhibitors (TKIs). This study aimed to assess t...

    Authors: Yu Liu, Liang Zhou, Yuntian Chen, Banghua Liao, Donghui Ye, Kunjie Wang and Hong Li

    Citation: BMC Urology 2019 19:49

    Content type: Research article

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  28. The efficacy of partial nephrectomy (PN) for T1b renal cell carcinoma (RCC) is controversial. The oncological outcomes, the change in postoperative renal function and the perioperative complications are unclear.

    Authors: Yu-Li Jiang, Cheng-Xia Peng, Heng-Zi Wang and Lu-Jie Qian

    Citation: BMC Urology 2019 19:48

    Content type: Research article

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  29. Interstitial cystitis/bladder pain syndrome (IC/BPS) and female sexual dysfunction (FSD) are common conditions that substantially reduce women’s health. In particular, women with IC/BPS show vulvodynia, a kind...

    Authors: Su Jin Kim, Jayoung Kim and Hana Yoon

    Citation: BMC Urology 2019 19:47

    Content type: Review

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  30. The identification of appropriate biomarkers is essential to support important clinical decisions in patients with prostate cancer. The aim of our study was a systematic bioinformatical analysis of the mRNA ex...

    Authors: Anika Kremer, Tobias Kremer, Glen Kristiansen and Yuri Tolkach

    Citation: BMC Urology 2019 19:46

    Content type: Research article

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  31. The prevalence of pure stress urinary incontinence (P-SUI) and the role of urodynamic investigation (UDI) prior to surgery for stress urinary incontinence (SUI) is debated. Since the exact prevalence of P-SUI ...

    Authors: Emanuele Rubilotta, Matteo Balzarro, Antonio D’Amico, Maria Angela Cerruto, Silvia Bassi, Chiara Bovo, Valerio Iacovelli, Daniele Bianchi, Walter Artibani and Enrico Finazzi Agrò

    Citation: BMC Urology 2019 19:44

    Content type: Research article

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  32. Urinary tract infection (UTI) is a common clinical problem in pregnant women. Bacteriuria in pregnancy without antibiotic treatment could result in complications. This study aims to investigate the etiology an...

    Authors: Milad Azami, Zahra Jaafari, Mansour Masoumi, Masoumeh Shohani, Gholamreza Badfar, Leily Mahmudi and Shamsi Abbasalizadeh

    Citation: BMC Urology 2019 19:43

    Content type: Research article

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  33. Prostate cancer is the most commonly diagnosed cancer in men. Radiotherapy represents one major treatment option in different therapeutic settings. As patients increasingly rely on internet-based medical infor...

    Authors: S. Janssen, F. B. Fahlbusch, L. Käsmann, D. Rades and D. Vordermark

    Citation: BMC Urology 2019 19:42

    Content type: Research article

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  34. Intrafascial prostatectomy was a modified technique from the conventional nerve-sparing surgery in order to improve patients’ post-surgical continence and erectile function; however, ongoing controversy exists...

    Authors: Xiao Wang, Yiqi Wu, Jia Guo, Hui Chen, Xiaodong Weng and Xiuheng Liu

    Citation: BMC Urology 2019 19:41

    Content type: Research article

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  35. Previously published results from our laboratory identified a mechano-gated two-pore domain potassium channel, TREK-1, as a main mechanosensor in the smooth muscle of the human urinary bladder. One of the limi...

    Authors: Ricardo H. Pineda, Joseph Hypolite, Sanghee Lee, Alonso Carrasco Jr, Nao Iguchi, Randall B. Meacham and Anna P. Malykhina

    Citation: BMC Urology 2019 19:40

    Content type: Research article

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  36. Testicular torsion (TT) is a urologic emergency that requires prompt surgical intervention. In rural Appalachia, patients are often transferred from surrounding communities due to lack of urologic care. We hyp...

    Authors: Tyler Overholt, Morris Jessop, John Barnard and Osama Al-Omar

    Citation: BMC Urology 2019 19:39

    Content type: Research article

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  37. To assess the prognostic value of the extent of positive surgical margins (PSM) following radical prostatectomy (RP) on biochemical recurrence (BR) with long-term follow-up.

    Authors: Yoann Koskas, François Lannes, Nicolas Branger, Sophie Giusiano, Nicolas Guibert, Géraldine Pignot, Jochen Walz, Dominique Rossi and Cyrille Bastide

    Citation: BMC Urology 2019 19:37

    Content type: Research article

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  38. Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) are exceptionally rare in the first decade of life (mostly if multifocal) and there is a lack of standardized recommendations for the pediatric...

    Authors: Palma Maurizi, Michele Antonio Capozza, Silvia Triarico, Maria Luisa Perrotta, Vito Briganti and Antonio Ruggiero

    Citation: BMC Urology 2019 19:36

    Content type: Case report

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  39. In clinical research information can be retrieved through various sources. The aim is to evaluate the agreement between answers in patient questionnaires and clinical reports in a study of patients after radic...

    Authors: David Bock, Eva Angenete, Anders Bjartell, Jonas Hugosson, Gunnar Steineck, Sofie Walming, Peter Wiklund and Eva Haglind

    Citation: BMC Urology 2019 19:35

    Content type: Research article

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  40. In this era of precision medicine, the DNA damage response (DDR) pathway has been shown to be a viable target of intervention in metastatic castration-resistant prostate cancer (CRPC) as approximately one-thir...

    Authors: Isaac E. Kim Jr, Sinae Kim, Arnav Srivastava, Biren Saraiya, Tina Mayer, Wun-Jae Kim and Isaac Yi Kim

    Citation: BMC Urology 2019 19:33

    Content type: Research article

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  41. Post-radical prostatectomy urinary incontinence (PPI) negatively affects the quality of life of patients. Accurate identification of the problem by physicians is essential for adequate postoperative management...

    Authors: Rafael Castilho Borges, Marcos Tobias-Machado, Estefânia Nicoleti Gabriotti, Francisco Winter dos Santos Figueiredo, Carlos Alberto Bezerra and Sidney Glina

    Citation: BMC Urology 2019 19:32

    Content type: Research article

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  42. To assess the technical feasibility and outcomes of robotic-assisted partial nephrectomy (RPN) with sequential segmental renal artery (SRA) clamping for multiple ipsilateral renal tumors (MIRTs).

    Authors: Jie Yang, Jia-dong Xia, Jian-xin Xue, Ning-hong Song, Chao Liang, Di Xi, Ya-min Wang and Zeng-jun Wang

    Citation: BMC Urology 2019 19:31

    Content type: Technical advance

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  43. Results from randomized phase III trials have shown that thrice-weekly docetaxel added to androgen-deprivation therapy (ADT) has a significant impact on the survival of patients with metastatic castration-naïv...

    Authors: Sang Eun Yoon, Youjin Kim, Jangho Cho, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byoung Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Su Jin Lee and Se Hoon Park

    Citation: BMC Urology 2019 19:30

    Content type: Research article

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  44. We analysed in vitro the appearance of commonly used ureteral stents with dual-energy computed tomography (DECT) and we used these characteristics to optimize the differentiation between stents and adjacent st...

    Authors: Giuseppe Magistro, Patrick Bregenhorn, Bernhard Krauß, Dominik Nörenberg, Melvin D’Anastasi, Anno Graser, Philipp Weinhold, Frank Strittmatter, Christian G. Stief and Michael Staehler

    Citation: BMC Urology 2019 19:29

    Content type: Research article

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