Figure 7From: Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival Schematic presentation of COX2 dependent and -independent signals involved in bladder cancer development. COX2-CK2α signal is associated with sustained activation of Akt. COX2 inhibitors suppress the COX2-CK2α-phosphorylated Akt and uPA signal, resulting in p27/p21 induction.Back to article page