Figure 5
From: The impact of discrete modes of spinal cord injury on bladder muscle contractility
Enhanced cholinergic sensitivity in detrusor tissue strips from injured rats versus controls. (A) Dose–response curves for carbachol in control, TX and CX bladders. *, control significantly lower than TX and CX, p < 0.05. (B) EC50 values generated from concentration-dependent carbachol contractions in bladder tissue from control, TX and CX. *, significantly lower than control, p < 0.05. (C) Original representative tracings from each group showing contractile responses to EFS at a frequency of 1 Hz. Stimulation began at 10 sec and terminated at 20 sec. Data represent mean ± SEM. (D) Frequency-response curves for EFS expressed as area of contraction. *, significantly lower than TX and CX, p < 0.05; #, significantly lower than TX, p < 0.05.