Table 1 Radiation sensitization targets
From: Radiosensitization in prostate cancer: mechanisms and targets
Proteins/genes | Site of the cell | Cellular process |
|---|---|---|
Rad17-RFC complex | Nucleus | DNA damage sensor |
9-1-1 complex | Nucleus | DNA damage sensor |
MRN complex | Nucleus | DNA damage sensor |
ATM (ataxia-telangiectasia mutated) | Nucleus | DNA repair |
ATR (ataxia- and Rad3-related) | Nucleus | DNA repair |
P53 | Nucleus | DNA repair |
MDM2 | Nucleus | Negative regulator of p53 |
Chk2 | Nucleus | Cell cycle |
p21 | Nucleus | Cell cycle |
Cyclin E-CDK2 complex | Nucleus | Cell cycle |
pRB | Nucleus | Cell cycle |
E2F | Nucleus | Cell cycle |
Cdc25A | Nucleus | Cell cycle |
CDK2 | Nucleus | Cell cycle |
CDK4 | Nucleus | Cell cycle |
Cyclin B-CDK1 complex | Nucleus | Cell cycle |
CAK (CDK activating kinase) | Nucleus | Cell cycle |
Histone H2AX | Nucleus | Nucleosome formation |
53BP1 | Nucleus | P53 phosphorylation |
Ki-67 | Nucleus | Cellular proliferation |
Bcl-2 | Mitochondria | Apoptosis |
Bax | Mitochondria | Apoptosis |
PTEN | Cytoplasm | Apoptosis and proliferation |
Akt | Cytoplasm, nucleus | Apoptosis and proliferation |
PAR-4 | Cytoplasm, nucleus | Apoptosis |
Caspase-1 | Cytoplasm | Apoptosis |
Ras | Cytoplasm, nucleus | Cell growth, differentiation, survival |
Cox-2 | Cytoplasm, nucleus | Cell growth, differentiation, survival |