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Table 3 Prognostics factors of 10 years prostate cancer mortality derived from Cox regression analysis among prostate cancer patients with prostatectomy

From: Determinants and effects of positive surgical margins after prostatectomy on prostate cancer mortality: a population-based study

 

Total

PC specific death

Unadjusted hazard ratio

Adjusted hazard ratioa

 

N

N

%

HR

(95% CI)

p-value

HR

(95% CI)

p-value

Surgical Margin

         

  Negativeb

775

12

1.6

1

 

0.010

   

  Positive

479

21

4.4

2.54*

(1.25-5.16)

    

Age class

         

  <60

342

12

3.5

1

 

0.004

1

 

0.001

  60-69

721

10

1.4

0.39*

(0.17-0.91)

 

0.28**

(0.11-0.66)

 

  ≥70

191

11

5.8

1.68

(0.74-3.81)

 

1.31

(0.56-3.02)

 

Period

         

  1990-99

303

17

5.6

1

 

0.156

   

  2000-08

951

16

1.7

0.60

(0.29-1.22)

    

Method of detection

        

  Screening

1046

23

2.2

1.00

 

0.109

   

  Symptoms

97

8

8.3

2.34*

(1.04-5.28)

    

  Other

111

2

1.8

0.89

(0.21-3.76)

    

Surgeon caseload

         

  High (>50)

1007

18

1.8

1

 

0.006

   

  Middle (15–50)

166

12

7.2

3.68***

(1.78-7.63)

    

  Low (<15)

75

3

4.0

2.31

(0.68-7.84)

    

  Unknown

6

0

0.0

-

     

Clinical T

         

  cT0-cT1

261

2

0.8

1

 

0.359

   

  cT2

456

13

2.9

2.92

(0.66-13.0)

    

  cT3

125

6

4.8

4.33

(0.87-21.5)

    

  cTx

412

12

2.9

3.06

(0.69-13.7)

    

Pathological T

         

  pT0-pT2

868

7

0.8

1

 

<0.001

1

 

0.0387

  pT3-pT4

386

26

6.7

6.97***

(3.02-16.1)

 

2.61*

(1.05-6.48)

 

PSA level

         

  0-9

662

10

1.5

1

 

<0.001

1

 

0.0379

  10-20

192

7

3.7

1.71

(0.65-4.52)

 

1.02

(0.38-2.76)

 

  21+

89

12

13.5

6.40***

(2.75-14.9)

 

2.89*

(1.18-7.08)

 

  Unknown

311

4

1.3

0.63

(0.20-2.01)

 

0.76

(0.23-2.46)

 

Gleason

         

  2-6

715

4

0.6

1

 

<0.001

1

 

<0.001

  7

431

12

2. 8

6.59**

(2.12-20.5)

 

5.28**

(1.67-16.7)

 

  8-10

97

16

16.5

37.8***

(12.6-113)

 

22.53***

(7.10-71.5)

 

  Unknown

11

1

9.1

12.6*

(1.40-113)

 

10.59*

(1.04-107)

 

Tumour percentagec

        

  <10%

756

6

0.8

1

 

<0.001

   

  ≥10%

435

24

5.5

5.88***

(2.40-14.4)

    

  Unknown

63

3

4.8

4.46*

(1.11-17.9)

    

Radiotherapyd

         

  No

1067

23

2.2

1

 

0.038

   

  Yes

187

10

5.4

2.19*

(1.04-4.61)

    

Total

1254

33

2.63

      
  1. Geneva Cancer Registry 1990–2008.
  2. aAdjusted HRs were calculated using Cox Backward Regression including the entire set of variables tested in crude analysis, except clinical T.
  3. bNegative and close.
  4. cRadiotherapy includes both salvage and adjuvant categories.
  5. dTumour percentage of the prostate was calculated as tumour volume divided by the prostate volume.
  6. CI: Confidence interval.
  7. PC: Prostate Cancer.
  8. *p < 0.05; **p < 0.01; ***p < 0.001.