Impact of preoperative 5α-reductase inhibitors on perioperative blood loss in patients with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials

Zhu, Yi-Ping; Dai, Bo; Zhang, Hai-Liang; Shi, Guo-hai; Ye, Ding-Wei

doi:10.1186/s12894-015-0043-4

Table 1 Study characteristics

From: Impact of preoperative 5α-reductase inhibitors on perioperative blood loss in patients with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials

Study	Country	Age		Sample size		Intervention		Dose and duration	Outcomes evaluated
		5ARI	Control	5ARI	Control	5ARI	Control
Sandfeldt 2001 [10]	Sweden	69	68	26	29	Fin	placebo	5mg daily, 12 weeks	blood loss, operating time, resection weight, MVD
HäggstrÖm 2002 [13]	Sweden	NM	NM	15	13	Fin	placebo	5mg daily, 12 weeks	VEGF, MVD
Donohue 2002 [8]	UK	69.9	70.2	32	36	Fin	placebo	5mg daily, 2 weeks	blood loss, resection weight
Liu 2003 [14]	China	68.9	68.4	50	50	Fin	blank	5mg daily, 2 weeks	blood loss, Hb alteration, operating time, resection weight, MVD, VEGF
Li 2004 [6]	China	70.7	72.1	40	40	Fin	blank	5mg daily, 1–2 weeks	blood loss, operating time, resection weigh
Özdal 2005 [4]	Turkey	66.9	66.3	20	20	Fin	blank	5mg daily, 4 weeks	blood loss, Hb alteration, resection weight
Lund 2005 [19]	Denmark	66.5	67	16	17	Fin	placebo	5mg daily, 12 weeks	blood loss, operating time, resection weight
Boccon 2005 [16]	France	NM	NM	32	27	Dut	placebo	0.5mg daily,4 weeks	Hb alteration, resection weight
Lekas 2006 [7]	Greece	68.6	68.8	88	90	Fin	blank	5mg daily, 25.3 weeks	blood loss, MVD ,VEGF
Hahn 2007 [20]	multicenter 3-arm study	67/67	66	72/71	70	Dut	placebo	0.5mg daily, 4 weeks before and 2 weeks after TURP	Hb alteration per gram prostate; MVD
Memis 2008 [11]	Turkey	65	64	13	17	Fin	blank	5mg daily, 4 weeks	MVD
Berardinis 2008 [9]	Italy	68	69	100	100	Fin	placebo	5mg twice, 8 weeks	MVD,VEGF
Tuncel 2009 [21]	Turkey	68.1	67.7	27	21	Dut	blank	0.5mg daily,5 weeks	Blood loss, Hb alteration, MVD
Kravchick 2009 [17]	Israel	67.7	66.15	24	22	Dut	blank	0.5mg daily,6 weeks	blood loss, operating time, resection weight
He 2012 [15]	China	64.5	65.5	30	30	Fin	blank	5mg daily, 2 weeks	blood loss, operating time, resection weight, MVD ,VEGF
Pastore 2013 [18]	Italy	65.66	66.7	71	71	Dut	blank	0.5mg daily,6 weeks	blood loss, operating time, resection weight
Liu 2013 [14]	China	69.2	68.4	90	90	Fin	blank	10mg twice, 2 weeks	blood loss, operating time, resection weight, VEGF

5ARI 5α-reductase inhibitors, Fin finasteride, Dut dutasteride, MVD microvessel density, VEGF vascular endothelial growth factor, RR relative risk, MD mean difference, CI confidence interval

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ISSN: 1471-2490

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