The combination of herbal medicine Weng-li-tong with Tolterodine may be better than Tolterodine alone in the treatment of overactive bladder in women: a randomized placebo-controlled prospective trial

Table 3 Efficacy comparison within groups at visit 5 (8 weeks)

Group (n)	Placebo^a (23)	WLT (39)	Tolterodine (41)	Combination (43)	P-value
Group (n)	Placebo^a (23)	WLT (39)	Tolterodine (41)	Combination (43)	Wvs T	W vs C	T vs C
OABSS	0.22 ± 0.83	−0.72 ± 1.71	−1.54 ± 1.07	−3.9 ± 1.8	0.022	<0.001	<0.001
Voids/24 h	- 0.21 ± 0.77	−0.97 ± 2.3	−2.2 ± 1.6	−3.9 ± 2.1	0.034	<0.001	<0.001
VV (ml)	−4.8 ± 15.1	10.9 ± 24.4	24.6 ± 21.6	49.6 ± 43.9	0.135	<0.001	0.001
UI/24 h	0.02 ± 0.45	−0.36 ± 0.58	−0.61 ± 0.63	−0.78 ± 0.85	0.113	0.008	0.281
RU (ml)	0.5 ± 2.8	−0.9 ± 3.9	11.5 ± 23.2	0.2 ± 3.8	<0.001	0.109	<0.001
QOL improvement in ITT patients	11.5 %	57.9 %	61.5 %	76.9 %	0.842	0.059	0.136

WLT weng-li-tong, OABSS overactive bladder symptom score, VV void volume, UI urinary incontinence, RU residual urine, QOL quality of life, ITT intent-to-treat, W weng-li-tong, T tolterodine, C combination
^aThe changes of OABSS, voids/24 h, VV and UI with improve rate in placebo group were all significantly less than other 3 groups (all P < 0.001), except RU change was similar to WLT (P = 0.131) or combination group (P = 0.312)

ISSN: 1471-2490