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Table 1 Diagnostic tests cost, sensitivity, and specificity

From: Serum and 24-hour urinary tests cost-effectiveness in stone formers

Diagnostic Test

Cost (USD)

Sensitivity

Specificity

Reference (Senstivity&Specifity)

Serum Chloride

1.01

0.82

0.89

Linda Shavit1,2, Lucia Chen1, Fayha Ahmed3, Pietro Manuel Ferraro4, Shabbir Moochhala1, Steven B. Walsh1, Robert Unwin. Selective screening for distal renal tubular acidosis in recurrent kidney stone formers: initial experience and comparison of the simultaneous furosemide and fludrocortisone with the short ammonium chloride test. Nephrology Dialysis Transplantation, Volume 31, Issue 11, November 2016, Pages 1870–1876

Urinary Calcium

1.18

0.57

0.68

Rossi MA, Singer EA, Golijanin DJ, Monk RD, Erturk E, Bushinsky DA. Sensitivity and specificity of 24-hour urine chemistry levels for detecting elevated calcium oxalate and calcium phosphate supersaturation. Canadian Urological Association Journal. 2008 Apr;2(2):117

Urinary Sodium

5.04

1.00

0.82

WolfgangWeger, Peter Kotanko, MartinWeger, Hannes Deutschmann and Falko Skrabal. Prevalence and characterization of renal tubular acidosis in patients with

Osteopenia and osteoporosis and in non-porotic controls. Nephrol Dial Transplant (2000) 15: 975–980

24 H Urine ph

0.98

1.00

0.62

Adrian Rossi, MD;* Eric A. Singer, MD;* Dragan J. Golijanin, MD;* Rebeca D. Monk, MD;† Erdal Erturk, MD;* David A. Bushinsky, MD†. Sensitivity and specificity of 24-hour urine chemistry levels for detecting elevated calcium oxalate and calcium phosphate supersaturation CUAJ 2008;2(2):117 − 22.

Urinary Oxalate

2.63

0.59

0.65

Rossi MA, Singer EA, Golijanin DJ, Monk RD, Erturk E, Bushinsky DA. Sensitivity and specificity of 24-hour urine chemistry levels for detecting elevated calcium oxalate and calcium phosphate supersaturation. Canadian Urological Association Journal. 2008 Apr;2(2):117

Serum IPTH-CLIA

5.72

0.90

0.77

Hyperparathyroidism (primary): diagnosis, assessment, and initial management Evidence review for Diagnostic Tests NICE guideline NG132 Diagnostic evidence review May 2019

Serum Sodium Na

1.08

0.82

0.31

Bruno Madeo,1 Elda Kara,1 Katia Cioni,1 Silvia Vezzani,1 Tommaso Trenti,2 Daniele Santi,1,3 Manuela Simoni,1,3,4 and Vincenzo Rochira. Serum Calcium to Phosphorous (Ca/P) Ratio Is a Simple, Inexpensive, and Accurate Tool in the Diagnosis of Primary Hyperparathyroidism. JBMR1 Plus, Vol. 2, No. 2, March 2018, pp 109–117

Serum Uric Acid

0.93

0.98

0.87

WolfgangWeger, Peter Kotanko, MartinWeger, Hannes Deutschmann and Falko Skrabal. Prevalence and characterization of renal tubular acidosis in patients with

Osteopenia, osteoporosis, and non-porotic controls. Nephrol Dial Transplant (2000) 15: 975–980

Urinary Uric Acid

0.93

0.79

0.92

Adrian Rossi, MD;* Eric A. Singer, MD;* Dragan J. Golijanin, MD;* Rebeca D. Monk, MD;† Erdal Erturk, MD;* David A. Bushinsky, MD†. Sensitivity and specificity of 24-hour urine chemistry levels for detecting elevated calcium oxalate and calcium phosphate supersaturation CUAJ 2008;2(2):117 − 22.

Urinary Magnesium

1.38

0.59

0.77

Adrian Rossi, MD;* Eric A. Singer, MD;* Dragan J. Golijanin, MD;* Rebeca D. Monk, MD;† Erdal Erturk, MD;* David A. Bushinsky, MD†. Sensitivity and specificity of 24-hour urine chemistry levels for detecting elevated calcium oxalate and calcium phosphate supersaturation CUAJ 2008;2(2):117 − 22.

Urinary Potassium

1.08

0.8060

0.8570

WolfgangWeger, Peter Kotanko, MartinWeger, Hannes Deutschmann and Falko Skrabal. Prevalence and characterization of renal tubular acidosis in patients with

Osteopenia, osteoporosis, and non-porotic controls. Nephrol Dial Transplant (2000) 15: 975–980

Urinary Citrate

7.86

0.8600

1.0000

WolfgangWeger, Peter Kotanko, MartinWeger, Hannes Deutschmann and Falko Skrabal. Prevalence and characterization of renal tubular acidosis in patients with

Osteopenia, osteoporosis, and non-porotic controls. Nephrol Dial Transplant (2000) 15: 975–980

Serum Calcium

1.18

0.9

0.99

Bruno Madeo,1 Elda Kara,1 Katia Cioni,1 Silvia Vezzani,1 Tommaso Trenti,2 Daniele Santi,1,3 Manuela Simoni,1,3,4 and Vincenzo Rochira. Serum Calcium to Phosphorous (Ca/P) Ratio Is a Simple, Inexpensive, and Accurate Tool in the Diagnosis of Primary Hyperparathyroidism. JBMR1 Plus, Vol. 2, No. 2, March 2018, pp 109–117

Serum Potassium K

1.08

0.96

0.99

Xilian Qiu1,*, Chunyong Liu2,*, Yuqiu Ye3,*, Huiqun Li3, Yanbing Chen4, Yongmei Fu3, Zhenjie Liu2, Xianzhang Huang2, Yunqiang Zhang5, Xueyuan Liao5, Hongyong Liu5,*, Wenbo Zhao3 and Xun Liu. The diagnostic value of serum creatinine and cystatin c in evaluating glomerular filtration rate in patients with chronic kidney disease: a systematic literature review and meta-analysis. Oncotarget, 2017, Vol. 8, (No. 42),

Serum Vit D

4.16

0.91

0.95

Hyperparathyroidism (primary): diagnosis, assessment, and initial management Evidence review for Diagnostic Tests NICE guideline NG132 Diagnostic evidence review May 2019

Urinary Cystine

1.33

0.95

0.72

Andreassen KH, Pedersen KV, Osther SS, Jung HU, Lildal SK, Osther PJ. How should patients with cystine stone disease be evaluated and treated in the twenty-first century? Urolithiasis. 2016 Feb;44:65–76.

Urinary Phosphate

3.68

1.00

0.94

Rossi MA, Singer EA, Golijanin DJ, Monk RD, Erturk E, Bushinsky DA. Sensitivity and specificity of 24-hour urine chemistry levels for detecting elevated calcium oxalate and calcium phosphate supersaturation. Canadian Urological Association Journal. 2008 Apr;2(2):117