Table 1 Inclusion / exclusion criteria

• Adult women (≥ 18 years of age)

• Clinically stable MS defined by an Expanded Disability Status Score (EDSS) ≤ 7.5 without exacerbation worsening in the preceding 6 months prior to study entry

• Montreal Cognitive Assessment (MoCA) score > 10

• Neurogenic Lower Urinary Tract Dysfunction symptoms ≥ 3 months with NBSS total ≥ 15

• At least one bladder storage symptom (e.g., urinary frequency, urinary urgency, or nocturia with or without incontinence) indicated by OAB-AT ≥ 8

• Pregnant or planning on becoming pregnant or nursing

• Bladder outlet obstruction

• Baclofen or other intrathecal pump, pacemakers

• History of seizure disorder (SZ), immediate family of SZ disorder

• History of bipolar disorder

• History of moderate to severe heart disease or unstable angina

• History of autonomic dysreflexia (AD)

• History of interstitial cystitis, or pelvic radiation

• Intradetrusor BTX-A injections within 6 months prior to study participation

• Active SNS or any other spinal stimulator

• Indwelling urethral or suprapubic catheter