Development and validation of two nomograms for predicting overall survival and Cancer-specific survival in prostate cancer patients with bone metastases: a population-based study

Table 4 Results of univariate and multivariate analyses by Fine-Gray proportional subdistribution hazards model

Variables	Univariate Cox regression analysis			Multivariate Cox regression analysis
Variables	HR	95% CI	P	HR	95% CI	P
age
<70	1 (reference)				1 (reference)
≥ 70	1.277	1.098–1.485	0.001	1.162	1.003–1.346	0.045
Race
American Indian/Alaska Native	1 (reference)
Asian/Pacific Islander	0.524	0.228–1.205	0.128
Black	0.868	0.408–1.849	0.714
White	0.677	0.321–1.425	0.304
T Stage
T1	1 (reference)
T2	0.989	0.832–1.175	0.897
T3	0.903	0.717–1.137	0.384
T4	1.186	0.924–1.521	0.181
N Stage
N1	1 (reference)
N0	0.906	0.770–1.066
Surgery
local	1 (reference)			1 (reference)
NO	0.869	0.691–1.095	0.234	0.873	0.698–1.091	0.231
Prostatectomy	0.439	0.203–0.952	0.037	0.341	0.162–0.719	0.005
Brain Metastasis
No		1 (reference)
Yes	1.840	0.652–5.189	0.249
Liver Metastasis
local	1 (reference)			1 (reference)
NO	2.522	1.644–3.870	0.000	2.8673	1.906–4.313	0.000
Lung Metastasis
local	1 (reference)			1 (reference)
NO	1.441	1.022–2.031	0.037	1.714	1.250–2.351	0.001
Gleason score
≤ 6	1 (reference)			1 (reference)
7(3 + 4)	2.048	0.956–4.388	0.065	2.271	1.055–4.887	0.036
7(4 + 3)	2.090	1.002–4.361	0.049	2.458	1.168–5.169	0.018
8	1.929	0.945–3.940	0.071	2.329	1.137–4.770	0.021
≥ 9	3.382	1.668–6.856	0.001	4.194	2.068–8.507	0.000
PSA
<4	1 (reference)
4 ~ 10	0.626	0.392–1.000	0.050
10 ~ 20	0.714	0.456–1.118	0.141
>20	0.994	0.657–1.505	0.977
Marital
Married	1 (reference)			1 (reference)
other	1.228	1.052–1.433	0.009	1.325	1.144–1.535	0.000
Chemotherapy
No		1 (reference)
Yes	1.100	0.906–1.336	0.334

ISSN: 1471-2490