Table 2 Diagnostic Accuracies for ECE Using mpMRI, 68 Ga-PSMA-11 PET/CT and MRI + PET/CT compared to Final Histology
mpMRI | 68 Ga-PSMA-11 PET/CT | mpMRI + PET/CT | ||
|---|---|---|---|---|
PI-RADS 1–5 | ||||
AUC (95%CI) | 0.69 (0.58–0.79)* | 0.74 (0.64–0.84) | 0.79 (0.70–0.88)* | |
Youden-selected threshold | 3 | 4 | 5 | |
Sensitivity, %, at threshold (95%CI) | 40 (28–54)* | 54 (40–67)† | 66 (52–78) *† | |
Specificity, %, at threshold (95%CI) | 94 (85–98) | 89 (77–95) | 85 (73–92) | |
ECE | Positive | 20 | 27 | 33 |
Negative | 30 | 23 | 17 | |
None-ECE | Positive | 3 | 6 | 8 |
Negative | 50 | 47 | 45 | |
PI-RADS 1–3 | ||||
AUC (95%CI) | 0.60 (0.41–0.78) | 0.56 (0.38–0.74) | 0.62 (0.47–0.79) | |
Youden-selected threshold | 3 | 3 | 3 | |
Sensitivity, %, at threshold (95%CI) | 28 (12–55) | 57 (32–79) | 92 (68–100) | |
Specificity, %, at threshold (95%CI) | 91 (78–97) | 54 (38–70) | 40 (26–56) | |
ECE | Positive | 4 | 6 | 13 |
Negative | 10 | 8 | 1 | |
None-ECE | Positive | 3 | 12 | 21 |
Negative | 32 | 23 | 14 | |
PI-RADS 4–5 | ||||
AUC (95%CI) | 0.70 (0.57–0.84)* | 0.85 (0.75–0.95) | 0.88 (0.79–0.98)* | |
Youden-selected threshold | 3 | 4 | 5 | |
Sensitivity, %, at threshold (95%CI) | 44 (30–60)* | 66 (50–80) | 80 (65–90)* | |
Specificity, %, at threshold (95%CI) | 100 (82–100) | 100 (82–100) | 100 (82–100) | |
ECE | Positive | 16 | 24 | 29 |
Negative | 20 | 12 | 7 | |
None-ECE | Positive | 0 | 0 | 0 |
Negative | 18 | 18 | 18 | |