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Fig. 4 | BMC Urology

Fig. 4

From: MicroRNA-148a-3p in pericyte-derived extracellular vesicles improves erectile function in diabetic mice by promoting cavernous neurovascular regeneration

Fig. 4

MCPs-EVs improved erectile function through miR-148a-3p in STZ-induced diabetic mice. a Representative ICP responses for age-matched nondiabetic controls, diabetic mice stimulated at 2 weeks after intracavernous PBS, MCPs-EVs-reagent control (MCPs-EVs-RC, 5 μg/20 μL), and MCPs-EVs-miR-148a-3p inhibitor (MCPs-EVs-miR-148a-3p-i, 5 μg/20 μL) injection. The cavernous nerve was stimulated at 5 V, and stimulus time is indicated by a solid bar. b, c Ratios of mean maximal ICP and total ICP (area under the curve) versus MSBP were calculated for each group. Data in graphs are mean ± SEM (n = 5). ***p < 0.001. STZ, streptozotocin; ICP, intracavernous pressure; MSBP, mean systolic blood pressure; MCPs, mouse corpus cavernous pericytes; ns, not significant

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BMC Urology

ISSN: 1471-2490

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