Table 2 Physiologic and metabolic parameters: 2 weeks after treatment with PBS, MCPs-EVs (RC), MCPs-EVs (miR-148a-3p i)

Body weight (g)

31.5 ± 0.6

23.7 ± 1.0*

25.3 ± 0.3*

25.8 ± 0.5*

Fasting glucose (mg/dl)

103.6 ± 2.6

551.2 ± 19.8*

567.2 ± 19.3*

549.4 ± 18.2*

Postprandial glucose (mg/dl)

168.8 ± 18.0

590.0 ± 6.4*

595.2 ± 4.8*

594.0 ± 5.7*

MSBP (mm Hg)

102.0 ± 2.6

101.2 ± 2.7

100.6 ± 1.9

102.0 ± 1.2