Fig. 2

Differentially expressed mRNAs in BPO patients’ groups before and after TURP. A Total number of differentially expressed genes (DEGs) in HP and MP groups compared to controls (edgeR (adjusted p-value< 0.1)). B Group classifier genes, determined as an overlap between edgeR, DESeq2 and PCA as described in the text. The pair-wise comparisons HP vs. MP before TURP and HP before and after TURP are indicated. C Principal component analysis (PCA) based on normalized read counts of HP vs. MP group 10 gene classifiers. Before_high samples are shown as red labelled dots, and before_medium as yellow labelled dots. D PCA based on normalized read counts of HP before TURP vs HP after TURP 12 gene classifiers. Before_high samples are shown as red labelled dots, and after_high as grey labelled dots. E PCA applied to all available datasets including controls using the combination of both classifiers (22 genes)