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Fig. 5 | BMC Urology

Fig. 5

From: De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors

Fig. 5

Differentially regulated proteins in BPO groups. A Total number of differentially expressed proteins (DEPs) in HP and MP groups compared to control before and after de-obstruction (adjusted p-value< 0.1). B Heatmap and hierarchical clustering based on Log2FC of normalized expression values of all DEPs compared to controls with p-value< 0.05. Proteins are represented in y-axis and patients’ samples before and after de-obstruction are shown in x-axis. One minus Pearson correlation metric was used for clustering accompanied with average linkage method. C Principal component analysis using top 500 variable proteins in HP and MP samples before and after TURP, and control samples. D Ten differentially expressed mRNAs and proteins in HP group before TURP. E 24 differentially expressed mRNAs and proteins in MP group before TURP. Regulation of protein levels (proteomics) is shown in orange, and mRNA (transcriptomics) shown in blue

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BMC Urology

ISSN: 1471-2490

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