Fig. 5
From: USP54 is a potential therapeutic target in castration-resistant prostate cancer
USP54 affects AR signaling in PCa. A, B GSEA of hallmark gene sets indicated that the androgen-response set was the most highly enriched in patients exhibiting high-level USP54 expression in the indicated PCa cohorts. The results are ranked according to normalized enrichment score and P-value. C, D The androgen-response gene set was used for GSEA of the various datasets based on USP54 transcriptional level. E The SU2C 2019 dataset was analyzed in terms of the correlation between the level of mRNA encoding USP54 and AR signaling activity. (F-G) Bar graph showing the levels of mRNAs encoding representative AR downstream target proteins after USP54 inhibition (t-test; ***P < 0.001)