Fig. 1
Erastin inhibits cell proliferation and induces ferroptosis in LNCaP and PC3 cells. (a) Phenotypic characterization of LNCaP and PC3 groups; “DMSO”, cells induced by DMSO as a negative control; “Erastin”, cells induced by erastin as an experimental group. (b) Expression of SLC7A11 was suppressed by erastin treatment in LNCaP and PC3 cells. (c) Proliferative levels of LNCaP and PC3 cells after erastin treatment. The relative MDA (d), Fe2+ (e), GSH (f), and GSH/GSSG (g) levels of LNCaP and PC3 cells treated with erastin were detected. Three independent experiments were performed with triplicate wells. Representative experiments and images are shown. Statistical significance was calculated using an independent-sample t-test. *p < 0.05, **p < 0.01, ***p < 0.001